View source for Pantoprazole

{{MedTemplate
| generic           = Pantoprazole
| brand             = Protonix
| structure         =
| classes           = [[:Category:Proton_pump_inhibitors|Proton pump inhibitor (PPI)]], [[:Category:Antisecretory_agents|Gastric acid suppressant]]
| uses              = <vote slug="gerd-use">GERD</vote>, <vote slug="erosive-esophagitis-use">Erosive esophagitis</vote>, <vote slug="zollinger-ellison-use">Zollinger-Ellison syndrome</vote>, <vote slug="stress-ulcer-prophylaxis-use">Stress ulcer prophylaxis</vote>
| starting_dose     = 40 mg PO or IV once daily
| preparations      = 20 mg, 40 mg delayed-release tablets; 40 mg IV vial; oral suspension 40 mg/packet
| fda_max           = 40 mg/d typical; up to 240 mg/d for Zollinger-Ellison
| pill_id           =
| routes            = Oral, IV
| onset             = 2-3 hours per dose; full acid suppression after 3-5 days
| duration          = 24+ hours (irreversible enzyme binding)
| halflife          = ~1 hour (plasma); pharmacodynamic effect persists 24+ hours<ref name="protonix-label">FDA Prescribing Information, Protonix (pantoprazole sodium), Pfizer, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020987s045,022020s016lbl.pdf</ref>
| bioavailability   = ~77% (oral; not affected by food or antacids)<ref name="protonix-label" />
| pregnancy         = Generally considered safe; widely used in obstetric reflux.{{citation needed}}
| legal             = [[USLegal:Prescription only|Rx-only]] in US
| mechanism         = <vote slug="pantoprazole-mech-claim">Pantoprazole is a prodrug irreversibly bound to the H+/K+ ATPase after acid-driven activation, blocking the final common step of gastric acid secretion.</vote> Compared with omeprazole, pantoprazole has a more linear pharmacokinetic profile and is metabolized predominantly via CYP2C19 with CYP3A4 contribution; less CYP2C19-driven drug interaction with clopidogrel than omeprazole<ref name="cpic-ppi-cyp2c19">CPIC Guideline for CYP2C19 and Proton Pump Inhibitors, 2020. https://cpicpgx.org/guidelines/cpic-guideline-for-proton-pump-inhibitors-and-cyp2c19/</ref>.
}}

== References ==
<references />