View source for Labetalol

{{MedTemplate
| generic           = Labetalol
| brand             = Trandate, Normodyne (discontinued in US)
| structure         =
| classes           = [[:Category:Beta blockers|Combined alpha-1 and non-selective beta blocker]], [[:Category:Antihypertensives|Antihypertensive]]
| uses              = <vote slug="hypertension-use">Hypertension (FDA)</vote>, <vote slug="hypertensive-crisis-use">Hypertensive crisis and severe hypertension (FDA, IV)</vote>, <vote slug="pregnancy-induced-hypertension-use">Hypertension in pregnancy, including preeclampsia and eclampsia (FDA; among the safest antihypertensives in pregnancy)</vote>
| starting_dose     = Oral: 100 mg PO BID, titrate to 400 mg BID. IV: 20 mg over 2 minutes, repeat 40-80 mg every 10 minutes as needed (maximum cumulative 300 mg); continuous infusion 2 mg/minute
| preparations      = Tablets 100, 200, 300 mg; injection 5 mg/mL
| fda_max           = 2400 mg/day (oral); 300 mg total per IV bolus dosing series
| pill_id           =
| routes            = Oral, intravenous
| onset             = BP effect within hours (oral); 5-10 minutes (IV)
| duration          = 8-12 hours (oral); 4-6 hours (IV)
| halflife          = ~6-8 hours<ref name="trandate-label">FDA Prescribing Information, Trandate (labetalol hydrochloride), Prometheus/Bausch, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/018716s022lbl.pdf</ref>
| bioavailability   = ~25% (oral; extensive first-pass)<ref name="trandate-label" />
| pregnancy         = '''Among the safest antihypertensives in pregnancy''', recommended for chronic hypertension during pregnancy and first-line for severe hypertension in preeclampsia and eclampsia<ref name="trandate-label" />
| legal             = [[USLegal:Prescription only|Rx-only]] in US
| mechanism         = <vote slug="labetalol-mech-claim">'''Combined α1-adrenergic and non-selective β-adrenergic receptor antagonist''' with approximately 1:3 α:β ratio orally and 1:7 IV. The combined α and β blockade lowers blood pressure through two complementary mechanisms: reduced cardiac output and renin secretion (the β effect, shared with all β-blockers) plus reduced peripheral vascular resistance via vasodilation (the α effect, distinguishing labetalol from selective β-blockers).</vote> The favorable pregnancy safety profile and the dual mechanism support its first-line role in pregnancy-associated hypertension and in hypertensive emergencies where rapid, controllable BP reduction is needed<ref name="trandate-label" />.
}}

== References ==
<references />

[[Category:Beta blockers]]
[[Category:Antihypertensives]]