View source for Receptor:5-HT2B

'''5-HT2B''' is a G protein-coupled [[Serotonin|serotonin]] receptor of the 5-HT2 family, coupling through Gq/11 proteins and [[Phospholipase C|phospholipase C]].<ref name="hoyer2002">Hoyer D, Hannon JP, Martin GR. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacology, Biochemistry, and Behavior. 2002 Apr;71(4):533-554. PMID: 11888546.</ref> It is expressed in the cardiovascular system, the gut, and parts of the central nervous system. Sustained agonism of 5-HT2B receptors on cardiac valve [[Fibroblast|fibroblasts]] drives proliferative valvular heart disease, the mechanism behind the valvulopathy associated with [[Fenfluramine|fenfluramine]], [[Pergolide|pergolide]], and other 5-HT2B agonists; screening out 5-HT2B activity is now a standard step in drug development.<ref name="roth2007">Roth BL. Drugs and valvular heart disease. New England Journal of Medicine. 2007 Jan 4;356(1):6-9. PMID: 17202450.</ref>

This page is a seed stub.

== References ==
<references/>

[[Category:Receptors]]