View source for Receptor:5-HT2C

'''5-HT2C''' is a G protein-coupled [[Serotonin|serotonin]] receptor of the 5-HT2 family, signaling through Gq/11 proteins and [[Phospholipase C|phospholipase C]], and is expressed almost exclusively in the central nervous system, where it contributes to the regulation of appetite, mood, and locomotor activity.<ref name="hoyer2002">Hoyer D, Hannon JP, Martin GR. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacology, Biochemistry, and Behavior. 2002 Apr;71(4):533-554. PMID: 11888546.</ref> 5-HT2C agonism suppresses appetite and was the mechanism of the anorectic medicine [[Lorcaserin|lorcaserin]], while 5-HT2C antagonism is one contributor to the weight gain associated with several [[:Category:Neuroleptics|neuroleptics]].

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== References ==
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[[Category:Receptors]]