MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:33Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Analgesics]]
			[[Category:Antipyretics]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #112

2026-05-23T03:46:16Z

parser-claude batch MedTemplate pre-fill, Top 300 #112

New page

{{MedTemplate
| generic = Acetaminophen (paracetamol, APAP)
| brand = Tylenol, Panadol (international), Ofirmev (IV); huge OTC presence
| structure =
| classes = [[:Category:Analgesics|Non-opioid analgesic]], [[:Category:Antipyretics|Antipyretic]]
| uses = <vote slug="mild-moderate-pain-use">Mild to moderate pain</vote>, <vote slug="fever-use">Fever</vote>, <vote slug="multimodal-analgesia-use">Multimodal post-surgical analgesia</vote>
| starting_dose = 325-1000 mg PO every 4-6 hours as needed; maximum 4 g/d in healthy adults, 3 g/d in regular users or hepatic risk; pediatric 10-15 mg/kg every 4-6 hours
| preparations = 325, 500, 650 mg tablets; 80, 160 mg chewables; 160 mg/5 mL pediatric liquid; 325 mg suppository; 1000 mg/100 mL IV (Ofirmev); fixed-dose combinations with opioids, decongestants, antihistamines
| fda_max = 4 g/d in healthy adults; 3 g/d conservative limit; 2 g/d in cirrhosis or chronic alcohol use
| pill_id =
| routes = Oral, rectal, IV
| onset = PO: 30-60 minutes; IV: minutes
| duration = 4-6 hours
| halflife = 1-3 hours (normal liver); markedly prolonged in overdose with glutathione depletion<ref name="tylenol-label">FDA OTC Monograph for acetaminophen-containing products, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021450s015lbl.pdf</ref>
| bioavailability = ~85-98% (oral)<ref name="tylenol-label" />
| pregnancy = Long the preferred analgesic-antipyretic in pregnancy; recent observational studies have raised speculative neurodevelopmental signals that remain under investigation.{{citation needed}}
| legal = OTC and [[USLegal:Prescription only|Rx-only]] (IV, combination products) in US
| mechanism = <vote slug="apap-mech-claim">Acetaminophen's analgesic and antipyretic actions are incompletely characterized; central COX inhibition (particularly the COX-2 splice variant sometimes called COX-3, and inhibition of arachidonic acid pathways in CNS at low peroxide concentrations) is the leading hypothesis, with possible contribution from descending serotonergic pathways and TRPV1 modulation by the AM404 metabolite.</vote> The absence of meaningful peripheral cyclooxygenase inhibition explains the lack of antiplatelet and anti-inflammatory effect compared with NSAIDs, and the gastroprotective profile. '''Dose-dependent hepatotoxicity''' via the CYP2E1 metabolite N-acetyl-p-benzoquinone imine (NAPQI) once glutathione is depleted; N-acetylcysteine is the antidote and is most effective within 8-10 hours of overdose<ref name="tylenol-label" />.
}}

== References ==
<references />

Acetaminophen - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #112