MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:31Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
Line 21:		Line 21:
	== References ==		== References ==
	<references />		<references />
			[[Category:Macrolide antibiotics]]
			[[Category:Azalides]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #64

2026-05-23T03:42:09Z

parser-claude batch MedTemplate pre-fill, Top 300 #64

New page

{{MedTemplate
| generic = Azithromycin
| brand = Zithromax, Z-Pak, Zmax
| structure =
| classes = [[:Category:Macrolide_antibiotics|Macrolide antibiotic]], [[:Category:Azalides|Azalide]]
| uses = <vote slug="cap-use">Community-acquired pneumonia (atypical coverage)</vote>, <vote slug="strep-throat-pcn-allergic-use">Streptococcal pharyngitis (penicillin-allergic)</vote>, <vote slug="sti-chlamydia-use">Chlamydial urethritis/cervicitis</vote>, <vote slug="mac-prophylaxis-use">MAC prophylaxis in HIV</vote>, <vote slug="copd-exacerbation-prevention-use">COPD exacerbation prevention (selected)</vote>, <vote slug="pertussis-use">Pertussis treatment and prophylaxis</vote>
| starting_dose = 500 mg PO day 1, then 250 mg PO daily days 2-5 (Z-Pak); 1 g PO single dose for chlamydia; pediatric dosing 10 mg/kg day 1, 5 mg/kg days 2-5
| preparations = 250 mg, 500 mg, 600 mg tablets; 100, 200 mg/5 mL suspension; 2 g ER suspension (Zmax); 500 mg IV
| fda_max = 500 mg/d (typical regimen); single 2 g for Zmax; 2 g for select STIs
| pill_id =
| routes = Oral, IV
| onset = Clinical improvement within 24-72 hours
| duration = Tissue half-life supports once-daily and post-treatment effect
| halflife = ~68 hours (terminal; reflects deep tissue accumulation, much longer than plasma)<ref name="zithromax-label">FDA Prescribing Information, Zithromax (azithromycin), Pfizer, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050670s032,050710s045,050784s032lbl.pdf</ref>
| bioavailability = ~37% (oral; food reduces absorption modestly)<ref name="zithromax-label" />
| pregnancy = Generally considered safe; commonly used in pregnancy when macrolide indicated.{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = <vote slug="azithromycin-mech-claim">Azithromycin reversibly binds the 23S rRNA of the bacterial 50S ribosomal subunit, blocking peptide chain translocation and inhibiting protein synthesis; the azalide nitrogen substitution at position 9a of the macrolactone ring extends acid stability and tissue penetration relative to erythromycin.</vote> Long tissue half-life (uptake into macrophages with delivery to infection sites) supports short courses. '''QT-interval prolongation''' is a recognized class effect; FDA 2013 advisory flagged increased cardiovascular death risk in patients with prolonged baseline QT, hypokalemia, or other risk factors<ref name="zithromax-label" />.
}}

== References ==
<references />

Azithromycin - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #64