Baclofen - Revision history

MDElliottMD: parser-claude: Baclofen MedTemplate refill, Top 300 stub upgrade

2026-05-23T06:51:48Z

parser-claude: Baclofen MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 06:51, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Baclofen		\| generic = Baclofen
	\| brand = Lioresal		\| brand = Lioresal (oral, intrathecal pump), Ozobax / Fleqsuvy (oral suspension), Gablofen (intrathecal), Lyvispah (oral granules)
	\| structure =		\| structure =
	\| classes = ~~GABAergic~~, ~~Muscle relaxant~~		\| classes = [[:Category:Skeletal muscle relaxants\|Skeletal muscle relaxant (centrally-acting)]], [[:Category:Antispastics\|Antispastic]], [[:Category:GABA-B receptor agonists\|GABA-B receptor agonist]]
	\| ~~mechanism = GABAB~~ receptor agonist		\| uses = <vote slug="spasticity-multiple-sclerosis-use">Spasticity in multiple sclerosis (FDA, oral and intrathecal)</vote>, <vote slug="spasticity-spinal-cord-injury-use">Spasticity in spinal cord injury (FDA, oral and intrathecal)</vote>, <vote slug="cerebral-palsy-spasticity-use">Cerebral palsy spasticity (FDA intrathecal; off-label oral)</vote>, <vote slug="alcohol-use-disorder-baclofen-use">Alcohol use disorder (off-label, evidence-supported, generally third-line)</vote>, <vote slug="persistent-hiccups-use">Persistent hiccups (off-label)</vote>, <vote slug="gerd-motility-use">GERD with esophageal motility dysfunction (off-label)</vote>, <vote slug="trigeminal-neuralgia-use">Trigeminal neuralgia adjunct (off-label)</vote>
	\| uses =		\| starting_dose = Oral: 5 mg PO TID, titrate by 5 mg per dose every 3 days. Intrathecal: bolus test dose, then continuous infusion via implanted pump
	\| starting_dose =		\| preparations = Tablets 5, 10, 20 mg; oral suspension 5 mg/5 mL (Ozobax, Fleqsuvy); intrathecal injection 50, 500, 1000, 2000 mcg/mL (Lioresal Intrathecal, Gablofen); oral granules (Lyvispah)
	\| preparations =		\| fda_max = 80 mg/day oral (higher off-label)
	\| fda_max =		\| pill_id =
	\| routes =		\| routes = Oral, intrathecal (via implanted infusion pump)
	\| onset =		\| onset = 1-2 hours (oral)
	\| duration =		\| duration = 4-6 hours (oral, TID-QID dosing)
	\| halflife =		\| halflife = 3-4 hours<ref name="lioresal-label">FDA Prescribing Information, Lioresal (baclofen), Saol Therapeutics/Novartis, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/017851s019lbl.pdf</ref>
	~~\| bioavailability =~~		\| bioavailability = ~70-85% (oral)<ref name="lioresal-label" />
	~~\| pregnancy~~ =		\| pregnancy = Limited human data.{{citation needed}}
	~~\| legal~~ =		\| legal = [[USLegal:Prescription only\|Rx-only]] in US. Not a controlled substance<ref name="lioresal-label" />
	\| ~~intro =~~		\| mechanism = <vote slug="baclofen-mech-claim">Selective agonist at the GABA-B receptor (the only metabotropic GABA receptor; distinct from the ionotropic GABA-A targeted by benzodiazepines and Z-class hypnotics). Reduces excitatory neurotransmitter release presynaptically and hyperpolarizes postsynaptic membranes, producing antispastic effect particularly at spinal cord interneurons.</vote> '''Severe withdrawal syndrome''' is the marquee adverse-event concern, especially with abrupt cessation of intrathecal administration: hyperthermia, altered mental status, hyperreflexia, rhabdomyolysis, and multiorgan failure can develop within 24-72 hours and progress to death. Gradual taper is essential after extended use; intrathecal pump failures are a recognized emergency<ref name="lioresal-label" />.
	~~\| pharmacokinetics~~ =
	~~\| pharmacodynamics~~ =
	\| ~~indications~~ =
	\| ~~dosing~~ =
	~~\| effects =~~
	\| ~~interactions~~ = ~~<pharmaInteractions~~/>
	\| ~~pregnancy_details =~~
	~~\| monitoring~~ =
	~~\| counseling~~ =
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references~~ =
	}}		}}

	~~[[Category:GABAergics]]~~		== References ==
	[[Category:~~Sedative-hypnotics~~]]		<references />
	[[Category:~~GABAB Receptor Agonists~~]]
	[[Category:~~Muscle relaxants~~]]		[[Category:Skeletal muscle relaxants]]
			[[Category:Antispastics]]
			[[Category:GABA-B receptor agonists]]

MDElliottMD: Category taxonomy ship: retag Sedative-Hypnotics -> Sedative-hypnotics

2026-05-22T00:35:43Z

Category taxonomy ship: retag Sedative-Hypnotics -> Sedative-hypnotics

← Older revision		Revision as of 00:35, 22 May 2026
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	[[Category:GABAergics]]		[[Category:GABAergics]]
	[[Category:Sedative-~~Hypnotics~~]]		[[Category:Sedative-hypnotics]]
	[[Category:GABAB Receptor Agonists]]		[[Category:GABAB Receptor Agonists]]
	[[Category:Muscle relaxants]]		[[Category:Muscle relaxants]]

MDElliottMD: Dedupe migration per interface-claude 2026-05-20: Muscle Relaxants (CNS-acting) merged into canonical Muscle relaxants. Member retagged.

2026-05-19T18:00:18Z

Dedupe migration per interface-claude 2026-05-20: Muscle Relaxants (CNS-acting) merged into canonical Muscle relaxants. Member retagged.

← Older revision		Revision as of 18:00, 19 May 2026
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	\| references =		\| references =
	}}		}}


	[[Category:GABAergics]]		[[Category:GABAergics]]
	[[Category:Sedative-Hypnotics]]		[[Category:Sedative-Hypnotics]]
	[[Category:GABAB Receptor Agonists]]		[[Category:GABAB Receptor Agonists]]
	[[Category:Muscle ~~Relaxants (CNS-acting)~~]]		[[Category:Muscle relaxants]]

MDElliottMD: Remove Category:Psychostimulants tag (not a psychostimulant — sedative/anxiolytic/anticonvulsant/non-stimulant carryover from Stimulants & Wake-Promoting Agents rename)

2026-05-18T00:48:03Z

Remove Category:Psychostimulants tag (not a psychostimulant — sedative/anxiolytic/anticonvulsant/non-stimulant carryover from Stimulants & Wake-Promoting Agents rename)

← Older revision		Revision as of 00:48, 18 May 2026
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	~~[[Category:Psychostimulants]]~~
	[[Category:GABAergics]]		[[Category:GABAergics]]
	[[Category:Sedative-Hypnotics]]		[[Category:Sedative-Hypnotics]]
	[[Category:GABAB Receptor Agonists]]		[[Category:GABAB Receptor Agonists]]
	[[Category:Muscle Relaxants (CNS-acting)]]		[[Category:Muscle Relaxants (CNS-acting)]]

MDElliottMD: Recategorize: Stimulants -> Psychostimulants

2026-05-17T10:50:33Z

Recategorize: Stimulants -> Psychostimulants

← Older revision		Revision as of 10:50, 17 May 2026
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	[[Category:~~Stimulants~~]]		[[Category:Psychostimulants]]
	[[Category:GABAergics]]		[[Category:GABAergics]]
	[[Category:Sedative-Hypnotics]]		[[Category:Sedative-Hypnotics]]
	[[Category:GABAB Receptor Agonists]]		[[Category:GABAB Receptor Agonists]]
	[[Category:Muscle Relaxants (CNS-acting)]]		[[Category:Muscle Relaxants (CNS-acting)]]

MDElliottMD: Recategorize: Stimulants & Wake-Promoting Agents -> Stimulants

2026-05-17T10:44:46Z

Recategorize: Stimulants & Wake-Promoting Agents -> Stimulants

← Older revision		Revision as of 10:44, 17 May 2026
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	[[Category:Stimulants ~~& Wake-Promoting Agents~~]]		[[Category:Stimulants]]
	[[Category:GABAergics]]		[[Category:GABAergics]]
	[[Category:Sedative-Hypnotics]]		[[Category:Sedative-Hypnotics]]
	[[Category:GABAB Receptor Agonists]]		[[Category:GABAB Receptor Agonists]]
	[[Category:Muscle Relaxants (CNS-acting)]]		[[Category:Muscle Relaxants (CNS-acting)]]

MDElliottMD: Comprehensive categorization: +GABAB Receptor Agonists, Muscle Relaxants (CNS-acting)

2026-05-15T18:42:13Z

Comprehensive categorization: +GABAB Receptor Agonists, Muscle Relaxants (CNS-acting)

← Older revision		Revision as of 18:42, 15 May 2026
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	[[Category:GABAergics]]		[[Category:GABAergics]]
	[[Category:Sedative-Hypnotics]]		[[Category:Sedative-Hypnotics]]
			[[Category:GABAB Receptor Agonists]]
			[[Category:Muscle Relaxants (CNS-acting)]]

MediaWiki default: Assign pharmacological categories from List_of_CNS-active_medicines

2026-05-14T15:06:57Z

Assign pharmacological categories from List_of_CNS-active_medicines

← Older revision		Revision as of 15:06, 14 May 2026
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	}}		}}


			[[Category:Stimulants & Wake-Promoting Agents]]
			[[Category:GABAergics]]
	[[Category:Sedative-Hypnotics]]		[[Category:Sedative-Hypnotics]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:30:42Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:30, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:24Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =