MDElliottMD: Create Bisoprolol scaffold

2026-05-15T07:15:41Z

Create Bisoprolol scaffold

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{{MedTemplate
| generic = Bisoprolol
| brand = Zebeta
| classes = Beta Blocker, Cardioselective (β1)
| uses = <vote slug="hypertension-use">Hypertension</vote>, <vote slug="heart-failure-use">Heart failure</vote>, <vote slug="angina-use">Angina</vote>
| starting_dose = 2.5–5 mg daily (HTN); 1.25 mg daily (HFrEF, slow titration)
| preparations = 5, 10 mg tabs
| fda_max = 20 mg/d
| routes = Oral
| onset = 1–2 h
| duration = 24 h
| halflife = 9–12 h
| bioavailability = ~90% (low first-pass)
| pregnancy = Category C
| legal = Rx-only in US
| mechanism = Highly β1-selective adrenergic antagonist. Greater selectivity than metoprolol or atenolol.
| intro = Bisoprolol is a highly β1-selective beta blocker and one of the four guideline-recommended agents for heart failure with reduced ejection fraction (alongside metoprolol succinate, carvedilol, and bucindolol). Its elimination is approximately 50% hepatic and 50% renal, which makes it forgiving in patients with either hepatic or renal impairment.
| indications =
| dosing =
| effects =
| pk_absorption = ~90% oral bioavailability; low first-pass extraction.
| pk_distribution = Plasma protein binding ~30%.
| pk_metabolism = ~50% hepatic; the rest excreted unchanged.
| pk_elimination = Renal (50% unchanged); balanced with hepatic clearance.
| pharmacodynamics =
| interactions = <pharmaInteractions/>
| pregnancy_details =
| monitoring = Heart rate, blood pressure; in HFrEF, watch for fluid retention during titration.
| counseling = Do not stop abruptly. Start very low (1.25 mg) in HFrEF and titrate every 1–2 weeks.
| anecdotes =
| seealso = [[Metoprolol]], [[Nebivolol]], [[Propranolol]]
| references = <references/>
}}

[[Category:Beta Blockers]]
[[Category:Medicines]]

Bisoprolol - Revision history

MDElliottMD: Create Bisoprolol scaffold