Bupropion - Revision history

MDElliottMD: parser-claude: Bupropion MedTemplate refill, Top 300 stub upgrade

2026-05-23T06:25:54Z

parser-claude: Bupropion MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 06:25, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Bupropion		\| generic = Bupropion
	\| brand = Wellbutrin		\| brand = Wellbutrin (IR, SR, XL), Zyban (smoking cessation), Aplenzin (hydrobromide salt), Forfivo XL
	\| structure =		\| structure =
	\| classes = NDRI, Antidepressant, ~~Stimulant~~		\| classes = [[:Category:NDRIs\|Norepinephrine-dopamine reuptake inhibitor (NDRI)]], [[:Category:Antidepressants\|Antidepressant]], [[:Category:Smoking cessation medicines\|Smoking cessation medicine]]
	\| ~~mechanism = Norepinephrine–dopamine reuptake inhibitor~~		\| uses = <vote slug="major-depressive-disorder-use">Major depressive disorder (FDA)</vote>, <vote slug="seasonal-affective-disorder-use">Seasonal affective disorder (FDA, Wellbutrin XL)</vote>, <vote slug="smoking-cessation-use">Smoking cessation (FDA, Zyban)</vote>, <vote slug="adhd-bupropion-use">Attention-deficit/hyperactivity disorder (off-label, especially with comorbid depression)</vote>, <vote slug="ssri-induced-sexual-dysfunction-use">SSRI-induced sexual dysfunction (off-label adjunct)</vote>, <vote slug="weight-loss-adjunct-use">Weight management (off-label, also as a component of Contrave)</vote>
	\| uses =		\| starting_dose = SR 150 mg PO once daily for 3 days, then 150 mg BID. XL 150 mg PO once daily for 4 days, then 300 mg once daily. Zyban (smoking cessation) 150 mg daily for 3 days, then 150 mg BID
	\| starting_dose =		\| preparations = SR tablets 100, 150, 200 mg; XL tablets 150, 300 mg; IR tablets 75, 100 mg (less common); Aplenzin (bupropion hydrobromide) 174, 348, 522 mg
	\| preparations =		\| fda_max = 450 mg/day; doses above this raise seizure risk steeply
	\| fda_max =		\| pill_id =
	\| routes =		\| routes = Oral
	\| onset =		\| onset = 1-2 weeks for antidepressant effect; smoking-cessation effect builds over the first 1-2 weeks
	\| duration =		\| duration = SR ~12 hours; XL 24 hours
	\| halflife =		\| halflife = Bupropion ~21 hours; hydroxybupropion (active metabolite) ~20-37 hours<ref name="wellbutrin-label">FDA Prescribing Information, Wellbutrin XL (bupropion hydrochloride extended-release), GSK/Bausch, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021515s039lbl.pdf</ref>
	\| bioavailability =		\| bioavailability = ~5-20% (extensive first-pass), highly variable between individuals<ref name="wellbutrin-label" />
	\| pregnancy =		\| pregnancy = Limited human data; some animal cardiac signal not clearly replicated in human cohort studies; observational signals inconclusive.{{citation needed}}
	\| legal =		\| legal = [[USLegal:Prescription only\|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults. Not controlled<ref name="wellbutrin-label" />
	\| ~~intro~~ = <vote slug="~~testing~~">~~hello~~</vote><~~vote slug~~="~~bup~~-~~rec" type="single" options="Yes; No; Maybe~~">		\| mechanism = <vote slug="bupropion-mech-claim">Selective norepinephrine and dopamine reuptake inhibitor with minimal serotonergic activity, distinguishing it sharply from the SSRI/SNRI antidepressants. Also a non-competitive nicotinic acetylcholine receptor antagonist, the proposed mechanism behind smoking-cessation efficacy. CYP2B6 produces the active metabolite hydroxybupropion, which contributes substantially to clinical effect.</vote> Lowers seizure threshold in a dose-dependent way; contraindicated in bulimia, anorexia nervosa, seizure disorder, and abrupt alcohol or benzodiazepine discontinuation. Bupropion is a '''strong CYP2D6 inhibitor''', raising plasma levels of many CYP2D6 substrates including tricyclic antidepressants, certain β-blockers, and certain neuroleptics<ref name="wellbutrin-label" />.
	~~Would you recommend Bupropion?~~		}}
	~~</vote>~~

	~~<vote slug="bup-side" type="multi" options="Dry mouth; Insomnia; Anxiety; Headache; None">~~		== References ==
	~~Which side effects did you experience?~~		<references />
	~~</vote>~~
	~~<vote slug~~=~~"open-poll" type~~=~~"single" options~~=~~"Yes; No; Maybe" open-ended~~=~~"true">~~
	~~What do you think? (Add your own option below.)~~
	<~~/vote>~~
	~~\| pharmacokinetics =~~
	~~\| pharmacodynamics =~~
	~~\| indications =~~
	~~\| dosing =~~
	~~\| effects =~~
	~~\| interactions = <pharmaInteractions~~/>
	~~\| pregnancy_details =~~
	~~\| monitoring =~~
	~~\| counseling =~~
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references =~~
	}}

			[[Category:NDRIs]]
	[[Category:Antidepressants]]		[[Category:Antidepressants]]
	[[Category:~~Norepinephrine–Dopamine Reuptake Inhibitors (NDRIs)~~]]		[[Category:Smoking cessation medicines]]

MDElliottMD at 20:14, 20 May 2026

2026-05-20T20:14:51Z

← Older revision		Revision as of 20:14, 20 May 2026
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	\| pregnancy =		\| pregnancy =
	\| legal =		\| legal =
	\| intro = <vote slug="bup-rec" type="single" options="Yes; No; Maybe">		\| intro = <vote slug="testing">hello</vote><vote slug="bup-rec" type="single" options="Yes; No; Maybe">
	Would you recommend Bupropion?		Would you recommend Bupropion?
	</vote>		</vote>

MDElliottMD at 17:11, 18 May 2026

2026-05-18T17:11:17Z

← Older revision		Revision as of 17:11, 18 May 2026
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	Which side effects did you experience?		Which side effects did you experience?
	</vote>		</vote>
	<vote slug="open-poll" type="single" options="Yes; No; Maybe" open-ended="true">		<vote slug="open-poll" type="single" options="Yes; No; Maybe" open-ended="true">
	What do you think? (Add your own option below.)		What do you think? (Add your own option below.)
	</vote>		</vote>
	\| pharmacokinetics =		\| pharmacokinetics =
	\| pharmacodynamics =		\| pharmacodynamics =

MDElliottMD at 16:38, 18 May 2026

2026-05-18T16:38:31Z

← Older revision		Revision as of 16:38, 18 May 2026
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	Which side effects did you experience?		Which side effects did you experience?
	</vote>		</vote>
			<vote slug="open-poll" type="single" options="Yes; No; Maybe" open-ended="true">
			What do you think? (Add your own option below.)
			</vote>
	\| pharmacokinetics =		\| pharmacokinetics =
	\| pharmacodynamics =		\| pharmacodynamics =

MDElliottMD at 02:04, 18 May 2026

2026-05-18T02:04:18Z

← Older revision		Revision as of 02:04, 18 May 2026
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	\| pregnancy =		\| pregnancy =
	\| legal =		\| legal =
	\| intro = <vote slug="~~test~~-~~single~~" type="single" options="Yes \| No \| Maybe">~~Try the single~~?</vote>		\| intro = <vote slug="bup-rec" type="single" options="Yes; No; Maybe">
			Would you recommend Bupropion?
			</vote>

	<vote slug="~~test~~-~~multi~~" type="multi" options="~~Dogs \| Cats \| Both \| Neither~~">~~Multi check~~?</vote>		<vote slug="bup-side" type="multi" options="Dry mouth; Insomnia; Anxiety; Headache; None">
			Which side effects did you experience?
			</vote>
	\| pharmacokinetics =		\| pharmacokinetics =
	\| pharmacodynamics =		\| pharmacodynamics =

MDElliottMD at 02:03, 18 May 2026

2026-05-18T02:03:02Z

← Older revision		Revision as of 02:03, 18 May 2026
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	\| pregnancy =		\| pregnancy =
	\| legal =		\| legal =
	\| intro =		\| intro = <vote slug="test-single" type="single" options="Yes \| No \| Maybe">Try the single?</vote>

			<vote slug="test-multi" type="multi" options="Dogs \| Cats \| Both \| Neither">Multi check?</vote>
	\| pharmacokinetics =		\| pharmacokinetics =
	\| pharmacodynamics =		\| pharmacodynamics =

MDElliottMD: Comprehensive categorization: +Norepinephrine–Dopamine Reuptake Inhibitors (NDRIs)

2026-05-15T18:42:06Z

Comprehensive categorization: +Norepinephrine–Dopamine Reuptake Inhibitors (NDRIs)

← Older revision		Revision as of 18:42, 15 May 2026
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	[[Category:Antidepressants]]		[[Category:Antidepressants]]
			[[Category:Norepinephrine–Dopamine Reuptake Inhibitors (NDRIs)]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:30:44Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:30, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:25Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =

MDElliottMD: Added empty fda_max parameter to MedTemplate call

2026-05-13T02:32:38Z

Added empty fda_max parameter to MedTemplate call

← Older revision		Revision as of 02:32, 13 May 2026
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	\| starting_dose =		\| starting_dose =
	\| preparations =		\| preparations =
			\| fda_max =
	\| routes =		\| routes =
	\| onset =		\| onset =
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	[[Category:Antidepressants]]		[[Category:Antidepressants]]