MDElliottMD: Create Cannabinol (CBN) medicine stub: minor phytocannabinoid, THC oxidation product, weak CB1 partial agonist, popularly framed as a sleep cannabinoid with sparse controlled evidence. Cites Russo 2011 entourage-effect review (PMID 21749363).

2026-05-19T06:22:20Z

Create Cannabinol (CBN) medicine stub: minor phytocannabinoid, THC oxidation product, weak CB1 partial agonist, popularly framed as a sleep cannabinoid with sparse controlled evidence. Cites Russo 2011 entourage-effect review (PMID 21749363).

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{{Stub}}
{{MedTemplate
| generic = Cannabinol
| classes = Cannabinoid (minor), phytocannabinoid, THC oxidation product
| mechanism = Weak CB1 partial agonist; weak CB2 partial agonist; multiple secondary targets.
| intro = '''Cannabinol''' (CBN) is a minor phytocannabinoid present in small concentrations in fresh [[Cannabis|cannabis]] and accumulating in stored, oxidized, or heat-degraded plant material as a non-enzymatic oxidation product of [[THC|delta-9-tetrahydrocannabinol]]. It binds the CB1 receptor with roughly one-tenth the affinity of THC and is at most very weakly psychoactive on its own. CBN is often described in popular sources as a "sleep cannabinoid", but the controlled evidence for a hypnotic effect is sparse; the sedation associated with old or degraded cannabis is more likely the combined contribution of CBN, other oxidation products, and shifts in terpene profile than CBN alone.<ref name="russo2011-entourage">Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. ''Br J Pharmacol''. 2011 Aug;163(7):1344-64. PMID: 21749363.</ref>
}}

[[Category:Cannabinoids]]

CBN - Revision history

MDElliottMD: Create Cannabinol (CBN) medicine stub: minor phytocannabinoid, THC oxidation product, weak CB1 partial agonist, popularly framed as a sleep cannabinoid with sparse controlled evidence. Cites Russo 2011 entourage-effect review (PMID 21749363).