MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:42Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Vitamin D analogs]]
			[[Category:Hormones]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #249

2026-05-23T04:15:06Z

parser-claude batch MedTemplate pre-fill, Top 300 #249

New page

{{MedTemplate
| generic = Calcitriol (1,25-dihydroxyvitamin D3)
| brand = Rocaltrol (oral), Calcijex (IV); topical Vectical for psoriasis
| structure =
| classes = [[:Category:Vitamin_D_analogs|Vitamin D analog (active form)]], [[:Category:Hormones|Hormone (steroid)]]
| uses = <vote slug="ckd-secondary-hyperparathyroidism-use">Secondary hyperparathyroidism in CKD</vote>, <vote slug="hypocalcemia-hypoparathyroidism-use">Hypocalcemia in hypoparathyroidism</vote>, <vote slug="renal-osteodystrophy-use">Renal osteodystrophy</vote>, <vote slug="vitamin-d-resistant-rickets-use">Vitamin D-resistant rickets</vote>, <vote slug="psoriasis-topical-use">Plaque psoriasis (topical)</vote>
| starting_dose = Oral 0.25 mcg daily, titrate by serum calcium and PTH; IV in CKD 0.5-3 mcg three times weekly
| preparations = 0.25, 0.5 mcg oral capsules; 1 mcg/mL oral solution; 1 mcg/mL IV; 3 mcg/g topical ointment
| fda_max = Titrated; risk of hypercalcemia is the limiting factor
| pill_id =
| routes = Oral, IV, topical
| onset = Days for calcium effect; weeks for PTH suppression
| duration = Hours per dose (much shorter biologic effect than ergocalciferol/cholecalciferol because it is the already-active form, not the storage form)
| halflife = ~5-8 hours<ref name="rocaltrol-label">FDA Prescribing Information, Rocaltrol (calcitriol), Validus, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/017636s048lbl.pdf</ref>
| bioavailability = High (oral)<ref name="rocaltrol-label" />
| pregnancy = Used when needed for hypoparathyroidism or renal osteodystrophy in pregnancy.{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = <vote slug="calcitriol-mech-claim">Calcitriol is the biologically active form of vitamin D (1,25-dihydroxyvitamin D3); it binds the vitamin D receptor (VDR) to drive transcription of genes governing intestinal calcium absorption, renal calcium reabsorption, bone calcium mobilization, and parathyroid PTH gene expression suppression.</vote> Bypasses the renal CYP27B1 hydroxylation step that fails in advanced CKD, making it (and 1α-hydroxylated analogs like paricalcitol) the active replacement for renal failure. Hypercalcemia is the dose-limiting adverse effect — frequent monitoring of calcium, phosphate, and PTH is standard<ref name="rocaltrol-label" />.
}}

== References ==
<references />

Calcitriol - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #249