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	<id>https://pharmacopedia.wiki/index.php?action=history&amp;feed=atom&amp;title=Category%3AEugeroics</id>
	<title>Category:Eugeroics - Revision history</title>
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	<updated>2026-05-28T06:48:19Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://pharmacopedia.wiki/index.php?title=Category:Eugeroics&amp;diff=5311&amp;oldid=prev</id>
		<title>MDElliottMD: Category taxonomy ship: retag Nootropics -&gt; Nootropics/Cognitive enhancers</title>
		<link rel="alternate" type="text/html" href="https://pharmacopedia.wiki/index.php?title=Category:Eugeroics&amp;diff=5311&amp;oldid=prev"/>
		<updated>2026-05-22T00:35:57Z</updated>

		<summary type="html">&lt;p&gt;Category taxonomy ship: retag Nootropics -&amp;gt; Nootropics/Cognitive enhancers&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 00:35, 22 May 2026&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l7&quot;&gt;Line 7:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 7:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:MedCategory]]&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:MedCategory]]&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:Psychostimulants]]&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:Psychostimulants]]&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
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&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:Pharmaceutical]]&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:Pharmaceutical]]&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>MDElliottMD</name></author>
	</entry>
	<entry>
		<id>https://pharmacopedia.wiki/index.php?title=Category:Eugeroics&amp;diff=4827&amp;oldid=prev</id>
		<title>MDElliottMD: Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)</title>
		<link rel="alternate" type="text/html" href="https://pharmacopedia.wiki/index.php?title=Category:Eugeroics&amp;diff=4827&amp;oldid=prev"/>
		<updated>2026-05-19T19:22:06Z</updated>

		<summary type="html">&lt;p&gt;Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 19:22, 19 May 2026&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l8&quot;&gt;Line 8:&lt;/td&gt;
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&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:Nootropics]]&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:Nootropics]]&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[Category:Pharmaceutical]]&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>MDElliottMD</name></author>
	</entry>
	<entry>
		<id>https://pharmacopedia.wiki/index.php?title=Category:Eugeroics&amp;diff=4663&amp;oldid=prev</id>
		<title>MDElliottMD: Create Category:Eugeroics: rename from the verbose &#039;Category:Eugeroics (Wakefulness-Promoting Agents)&#039;. Brief intro covering the modafinil family + pitolisant; preserves parent-category tags (Psychostimulants, Nootropics).</title>
		<link rel="alternate" type="text/html" href="https://pharmacopedia.wiki/index.php?title=Category:Eugeroics&amp;diff=4663&amp;oldid=prev"/>
		<updated>2026-05-19T03:42:15Z</updated>

		<summary type="html">&lt;p&gt;Create Category:Eugeroics: rename from the verbose &amp;#039;Category:Eugeroics (Wakefulness-Promoting Agents)&amp;#039;. Brief intro covering the modafinil family + pitolisant; preserves parent-category tags (Psychostimulants, Nootropics).&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;The &amp;#039;&amp;#039;&amp;#039;eugeroics&amp;#039;&amp;#039;&amp;#039; are a small class of medicines used to promote wakefulness, prescribed principally for [[narcolepsy]] and other disorders of excessive daytime sleepiness, and increasingly off-label for shift-work sleep disorder, residual fatigue in depression, and as cognitive performance aids. They are distinct from the amphetamine-type [[:Category:Psychostimulants|psychostimulants]]: their activating effect is more selective and less euphorigenic, their effect on heart rate and blood pressure is smaller, and their potential for dependence is generally lower, though not absent.&lt;br /&gt;
&lt;br /&gt;
The class is small and pharmacologically heterogeneous. Three members ([[Modafinil|modafinil]], [[Armodafinil|armodafinil]], and [[Adrafinil|adrafinil]]) share a related mechanism centred on dopamine reuptake inhibition with additional effects on histamine and orexin signalling; modafinil was introduced in France in the 1990s under the brand Provigil, armodafinil is its R-enantiomer (Nuvigil), and adrafinil is the older prodrug that is metabolized to modafinil. [[Pitolisant|Pitolisant]] (Wakix), the newest member, is mechanistically distinct: it is a selective histamine H3 receptor inverse agonist, raising histamine release in the brain to promote arousal.&lt;br /&gt;
&lt;br /&gt;
The word &amp;quot;eugeroic&amp;quot; comes from the Greek &amp;#039;&amp;#039;eu-&amp;#039;&amp;#039; (good) and &amp;#039;&amp;#039;egeirein&amp;#039;&amp;#039; (to wake). The synonymous label &amp;#039;&amp;#039;&amp;#039;wakefulness-promoting agents&amp;#039;&amp;#039;&amp;#039; is also common in the literature.&lt;br /&gt;
&lt;br /&gt;
[[Category:MedCategory]]&lt;br /&gt;
[[Category:Psychostimulants]]&lt;br /&gt;
[[Category:Nootropics]]&lt;/div&gt;</summary>
		<author><name>MDElliottMD</name></author>
	</entry>
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