Category:PDE5 Inhibitors - Revision history

MDElliottMD: Category taxonomy ship: add Category:Non-psychotropic medicines

2026-05-22T00:38:31Z

Category taxonomy ship: add Category:Non-psychotropic medicines

← Older revision		Revision as of 00:38, 22 May 2026
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	[[Category:Medicines]]		[[Category:Medicines]]
	[[Category:Pharmaceutical]]		[[Category:Pharmaceutical]]
			[[Category:Non-psychotropic medicines]]

MDElliottMD: Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)

2026-05-19T19:22:08Z

Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)

← Older revision		Revision as of 19:22, 19 May 2026
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	[[Category:MedCategory]]		[[Category:MedCategory]]
	[[Category:Medicines]]		[[Category:Medicines]]
			[[Category:Pharmaceutical]]

MDElliottMD: Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved.

2026-05-19T03:16:14Z

Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved.

← Older revision		Revision as of 03:16, 19 May 2026
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	== Class members ==		== Class members ==
	* [[Sildenafil]] (Viagra, Revatio) — first-in-class, FDA-approved 1998, half-life ~4 h		* [[Sildenafil]] (Viagra, Revatio), first-in-class, FDA-approved 1998, half-life ~4 h
	* [[Vardenafil]] (Levitra, Staxyn) — similar profile to sildenafil		* [[Vardenafil]] (Levitra, Staxyn), similar profile to sildenafil
	* [[Tadalafil]] (Cialis, Adcirca) — long-acting, half-life ~17.5 h ("weekend pill")		* [[Tadalafil]] (Cialis, Adcirca), long-acting, half-life ~17.5 h ("weekend pill")
	* [[Avanafil]] (Stendra) — newer, faster onset (~15 min), more selective		* [[Avanafil]] (Stendra), newer, faster onset (~15 min), more selective

	== Universal warnings ==		== Universal warnings ==
	* '''Absolutely contraindicated with any nitrate''' — life-threatening hypotension		* '''Absolutely contraindicated with any nitrate''', life-threatening hypotension
	* Caution with alpha-blockers — separate doses by ≥4 h		* Caution with alpha-blockers, separate doses by ≥4 h
	* Avoid in patients where sexual activity itself is contraindicated by cardiovascular instability		* Avoid in patients where sexual activity itself is contraindicated by cardiovascular instability
	* All metabolized through CYP3A4 — strong inhibitors (azoles, protease inhibitors) raise levels		* All metabolized through CYP3A4, strong inhibitors (azoles, protease inhibitors) raise levels

	[[Category:MedCategory]]		[[Category:MedCategory]]
	[[Category:Medicines]]		[[Category:Medicines]]

MDElliottMD: Create PDE5 Inhibitors class category

2026-05-15T15:30:26Z

Create PDE5 Inhibitors class category

New page

'''Phosphodiesterase type 5 (PDE5) inhibitors''' block the enzyme that degrades cyclic guanosine monophosphate (cGMP) in vascular smooth muscle. By preserving cGMP signaling downstream of nitric oxide, they enhance vasodilation in the corpus cavernosum (treating erectile dysfunction) and the pulmonary vasculature (treating pulmonary arterial hypertension).

== Class members ==
* [[Sildenafil]] (Viagra, Revatio) — first-in-class, FDA-approved 1998, half-life ~4 h
* [[Vardenafil]] (Levitra, Staxyn) — similar profile to sildenafil
* [[Tadalafil]] (Cialis, Adcirca) — long-acting, half-life ~17.5 h ("weekend pill")
* [[Avanafil]] (Stendra) — newer, faster onset (~15 min), more selective

== Universal warnings ==
* '''Absolutely contraindicated with any nitrate''' — life-threatening hypotension
* Caution with alpha-blockers — separate doses by ≥4 h
* Avoid in patients where sexual activity itself is contraindicated by cardiovascular instability
* All metabolized through CYP3A4 — strong inhibitors (azoles, protease inhibitors) raise levels

[[Category:MedCategory]]
[[Category:Medicines]]