MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:40Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Cephalosporins]]
			[[Category:Beta-lactam antibiotics]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #279

2026-05-23T04:08:52Z

parser-claude batch MedTemplate pre-fill, Top 300 #279

New page

{{MedTemplate
| generic = Cefuroxime (axetil oral, sodium IV)
| brand = Ceftin (oral), Zinacef (IV)
| structure =
| classes = [[:Category:Cephalosporins|Cephalosporin (second-generation)]], [[:Category:Beta-lactam_antibiotics|β-lactam antibiotic]]
| uses = <vote slug="otitis-media-use">Acute otitis media</vote>, <vote slug="acute-bacterial-sinusitis-use">Acute bacterial sinusitis</vote>, <vote slug="strep-pharyngitis-use">Streptococcal pharyngitis</vote>, <vote slug="cap-use">Community-acquired pneumonia (mild outpatient)</vote>, <vote slug="lyme-use">Lyme disease (alternative to doxycycline)</vote>, <vote slug="early-uncomplicated-gonorrhea-use">Uncomplicated gonorrhea (with azithromycin, historical; ceftriaxone now preferred)</vote>
| starting_dose = 250-500 mg PO BID × 7-14 days; IV 1.5 g q8h for serious infections
| preparations = 125, 250, 500 mg tablets; 125 mg/5 mL, 250 mg/5 mL suspension; 750 mg, 1.5 g IV vials
| fda_max = 1 g/d (oral); 6 g/d (IV)
| pill_id =
| routes = Oral, IV, IM
| onset = Hours
| duration = 8-12 hours
| halflife = ~1.5 hours<ref name="ceftin-label">FDA Prescribing Information, Ceftin (cefuroxime axetil), GSK, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/050605s039lbl.pdf</ref>
| bioavailability = ~37% (oral, as axetil prodrug; food modestly improves absorption)<ref name="ceftin-label" />
| pregnancy = Generally considered safe in pregnancy.{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = <vote slug="cefuroxime-mech-claim">Cefuroxime axetil is a prodrug hydrolyzed by intestinal esterases to cefuroxime; like all β-lactams it binds penicillin-binding proteins (PBPs) and inhibits transpeptidation of peptidoglycan cross-links, producing bactericidal cell wall destabilization.</vote> Second-generation cephalosporin spectrum: improved gram-negative activity relative to first-generation cephalexin while retaining gram-positive activity and adding some β-lactamase stability. Cefuroxime crosses the blood-brain barrier sufficiently for Lyme disease but not reliably for bacterial meningitis (where third-generation agents are preferred)<ref name="ceftin-label" />.
}}

== References ==
<references />

Cefuroxime - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #279