MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:34Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Thiazide-like diuretics]]
			[[Category:Antihypertensives]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #124

2026-05-23T03:51:55Z

parser-claude batch MedTemplate pre-fill, Top 300 #124

New page

{{MedTemplate
| generic = Chlorthalidone
| brand = Thalitone; mostly prescribed generically
| structure =
| classes = [[:Category:Thiazide-like_diuretics|Thiazide-like diuretic]], [[:Category:Antihypertensives|Antihypertensive]]
| uses = <vote slug="hypertension-use">Hypertension</vote>, <vote slug="edema-use">Edema</vote>, <vote slug="nephrogenic-di-use">Nephrogenic diabetes insipidus</vote>
| starting_dose = 12.5-25 mg PO once daily; titrate to 50 mg
| preparations = 15 mg, 25 mg, 50 mg tablets
| fda_max = 100 mg/d (rarely used)
| pill_id =
| routes = Oral
| onset = Diuresis at 2-3 hours; BP effect over weeks
| duration = 48-72 hours per dose (much longer than hydrochlorothiazide)
| halflife = 40-60 hours (notable for the thiazide class)<ref name="thalitone-label">FDA Prescribing Information, chlorthalidone tablets, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/012109s015lbl.pdf</ref>
| bioavailability = ~65% (oral)<ref name="thalitone-label" />
| pregnancy = Avoided where possible; same class concerns as HCTZ.{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = <vote slug="chlorthalidone-mech-claim">Chlorthalidone inhibits the Na+/Cl- cotransporter (NCC) in the distal convoluted tubule, producing the same natriuretic and vasodilatory effects as hydrochlorothiazide but with a substantially longer half-life that yields more sustained 24-hour BP control and modest evidence of better cardiovascular outcomes (ALLHAT, SHEP).</vote> Despite the favorable trial data, hydrochlorothiazide remains the dominant US thiazide prescription due to pricing and habit. Hyponatremia, hypokalemia, hypomagnesemia, hyperuricemia, hyperglycemia, and erectile dysfunction are characteristic class effects<ref name="thalitone-label" />.
}}

== References ==
<references />

Chlorthalidone - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #124