MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:31Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
Line 21:		Line 21:
	== References ==		== References ==
	<references />		<references />
			[[Category:Vitamin D analogs]]
			[[Category:Fat-soluble vitamins]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #68

2026-05-23T03:42:09Z

parser-claude batch MedTemplate pre-fill, Top 300 #68

New page

{{MedTemplate
| generic = Cholecalciferol (vitamin D3)
| brand = Many OTC; Rx 50,000 IU also available
| structure =
| classes = [[:Category:Vitamin_D_analogs|Vitamin D analog]], [[:Category:Fat-soluble_vitamins|Fat-soluble vitamin]]
| uses = <vote slug="vitamin-d-deficiency-use">Vitamin D deficiency</vote>, <vote slug="osteomalacia-use">Osteomalacia</vote>, <vote slug="rickets-use">Nutritional rickets</vote>, <vote slug="osteoporosis-adjunct-use">Osteoporosis (adjunct to calcium and antiresorptives)</vote>
| starting_dose = Maintenance 800-2,000 IU PO daily; deficiency replacement 50,000 IU PO weekly for 8-12 weeks then maintenance, or equivalent daily dosing 5,000-10,000 IU/d
| preparations = OTC 400, 1,000, 2,000, 5,000 IU softgels and tablets; Rx 50,000 IU capsules; liquid drops 400-2,000 IU/drop
| fda_max = No strict; Institute of Medicine UL 4,000 IU/d in adults for chronic use
| pill_id =
| routes = Oral, IM (rare, for severe malabsorption)
| onset = Weeks to raise 25(OH)D into reference range
| duration = Long; fat-soluble storage in adipose
| halflife = ~24 hours (parent); ~15 days (25(OH)D); tissue stores months
| bioavailability = ~75% (oral; absorption improved with fat-containing meal)
| pregnancy = Safe at replacement doses; deficiency is itself a risk in pregnancy and lactation.{{citation needed}}
| legal = OTC (most) and [[USLegal:Prescription only|Rx-only]] (50,000 IU) in US
| mechanism = <vote slug="cholecalciferol-mech-claim">Cholecalciferol (D3) is the form synthesized endogenously in skin from 7-dehydrocholesterol under UVB; like ergocalciferol (D2), it is hydroxylated by hepatic CYP2R1 to 25-hydroxyvitamin D (the storage form measured clinically) and then by renal CYP27B1 to 1,25-dihydroxyvitamin D (calcitriol), the active hormone binding the vitamin D receptor (VDR).</vote> D3 is more potent than D2 at raising and sustaining serum 25(OH)D per dose, and is the more common OTC formulation; D2 remains the dominant Rx 50,000 IU formulation in the US for historical reasons.
}}

== References ==
<references />

Cholecalciferol - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #68