MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:45Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
Line 21:		Line 21:
	== References ==		== References ==
	<references />		<references />
			[[Category:Lincosamides]]
			[[Category:Antibacterials]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #149

2026-05-23T04:21:34Z

parser-claude batch MedTemplate pre-fill, Top 300 #149

New page

{{MedTemplate
| generic = Clindamycin
| brand = Cleocin (oral, IV); Clindesse, Cleocin (vaginal); Clindets, Cleocin T (topical)
| structure =
| classes = [[:Category:Lincosamides|Lincosamide antibiotic]], [[:Category:Antibacterials|Antibacterial]]
| uses = <vote slug="ssti-use">Skin and soft tissue infections (including some MRSA strains)</vote>, <vote slug="dental-anaerobic-use">Anaerobic odontogenic infections</vote>, <vote slug="bacterial-vaginosis-use">Bacterial vaginosis (vaginal)</vote>, <vote slug="acne-vulgaris-topical-use">Acne vulgaris (topical, often with benzoyl peroxide)</vote>, <vote slug="strep-toxic-shock-use">Adjunct to β-lactam in toxin-mediated streptococcal/staphylococcal infections (toxic shock, necrotizing fasciitis) for ribosomal suppression of toxin production</vote>, <vote slug="dental-prophylaxis-pcn-allergic-use">Dental prophylaxis in penicillin allergy</vote>
| starting_dose = Oral 300-450 mg PO QID; IV 600-900 mg q8h; topical 1% solution/gel BID; vaginal 100 mg ovule × 3 days or 2% cream × 7 days
| preparations = 75, 150, 300 mg capsules; 75 mg/5 mL solution; 150 mg/mL IV; 1% topical; 2% vaginal cream
| fda_max = 4.8 g/d (IV severe infection)
| pill_id =
| routes = Oral, IV, IM, topical, vaginal
| onset = Hours
| duration = 6-8 hours
| halflife = ~2.5-3 hours<ref name="cleocin-label">FDA Prescribing Information, Cleocin HCl (clindamycin HCl), Pfizer, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050162s100lbl.pdf</ref>
| bioavailability = ~90% (oral)<ref name="cleocin-label" />
| pregnancy = Generally considered safe.{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' for Clostridioides difficile colitis (one of the most C. difficile-inducing antibiotic classes)<ref name="cleocin-label" />
| mechanism = <vote slug="clindamycin-mech-claim">Clindamycin reversibly binds the 23S rRNA of the bacterial 50S ribosomal subunit at a site overlapping the macrolide binding site, blocking peptide bond formation and inhibiting protein synthesis; the result is bacteriostatic against most organisms and bactericidal at high concentrations against susceptible strains.</vote> Active against gram-positives (Staph including some MRSA, streptococci including viridans), anaerobes (Bacteroides, Clostridia other than difficile, Peptostreptococcus), and Toxoplasma. Inducible MLSb resistance (D-test required for staph) and rising community MRSA resistance limit empiric reliability. Strong association with C. difficile colitis is the clinical-use ceiling<ref name="cleocin-label" />.
}}

== References ==
<references />

Clindamycin - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #149