MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:40Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Antifungals]]
			[[Category:Topical antifungals]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #259

2026-05-23T04:08:52Z

parser-claude batch MedTemplate pre-fill, Top 300 #259

New page

{{MedTemplate
| generic = Clotrimazole
| brand = Lotrimin, Mycelex, Gyne-Lotrimin; OTC widely
| structure =
| classes = [[:Category:Antifungals|Antifungal (imidazole)]], [[:Category:Topical_antifungals|Topical antifungal]]
| uses = <vote slug="tinea-pedis-use">Tinea pedis</vote>, <vote slug="tinea-corporis-use">Tinea corporis / cruris</vote>, <vote slug="cutaneous-candidiasis-use">Cutaneous candidiasis</vote>, <vote slug="vulvovaginal-candidiasis-use">Vulvovaginal candidiasis</vote>, <vote slug="oropharyngeal-candidiasis-use">Oropharyngeal candidiasis (troche)</vote>
| starting_dose = Topical: 1% cream BID × 2-4 weeks; vaginal: 1% or 2% cream nightly × 7 days, or 100/200/500 mg vaginal tablet single or 3-day regimens; troche: 10 mg PO five times daily × 2 weeks for thrush
| preparations = 1% topical cream, lotion, solution; 1%, 2% vaginal cream; 100, 200, 500 mg vaginal tablets; 10 mg oral troches; combination with betamethasone (Lotrisone, Rx)
| fda_max = Topical: BID; troche: 5×/day
| pill_id =
| routes = Topical, vaginal, oral troche
| onset = Days
| duration = Hours per application
| halflife = Not meaningfully described (minimal systemic absorption from topical use)<ref name="lotrimin-label">FDA Prescribing Information, Lotrimin AF (clotrimazole) OTC monograph, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/017812s041lbl.pdf</ref>
| bioavailability = Topical: minimal systemic; troche: ~3% systemic<ref name="lotrimin-label" />
| pregnancy = Topical and vaginal generally considered safe; widely used.{{citation needed}}
| legal = OTC (lower strengths) and [[USLegal:Prescription only|Rx-only]] (combination with betamethasone) in US
| mechanism = <vote slug="clotrimazole-mech-claim">Clotrimazole is an imidazole antifungal that inhibits fungal cytochrome P450 14α-demethylase (CYP51), blocking ergosterol biosynthesis and disrupting fungal cell membrane integrity.</vote> Active against dermatophytes (Trichophyton, Microsporum, Epidermophyton), Candida species, Malassezia, and some gram-positives at high concentrations. Topical use largely avoids the CYP-mediated drug interactions and hepatotoxicity that limit oral ketoconazole<ref name="lotrimin-label" />.
}}

== References ==
<references />

Clotrimazole - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #259