MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:32Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Vitamins]]
			[[Category:B-vitamins]]
			[[Category:Hematinics]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #104

2026-05-23T03:46:15Z

parser-claude batch MedTemplate pre-fill, Top 300 #104

New page

{{MedTemplate
| generic = Cyanocobalamin (vitamin B12)
| brand = Many OTC and Rx; Nascobal (intranasal); generic injection
| structure =
| classes = [[:Category:Vitamins|Vitamin]], [[:Category:B-vitamins|B-vitamin]], [[:Category:Hematinics|Hematinic]]
| uses = <vote slug="b12-deficiency-use">Vitamin B12 deficiency</vote>, <vote slug="pernicious-anemia-use">Pernicious anemia</vote>, <vote slug="post-bariatric-supplementation-use">Post-bariatric / malabsorptive supplementation</vote>, <vote slug="vegan-supplementation-use">Vegetarian/vegan supplementation</vote>
| starting_dose = Replacement: 1000 mcg IM daily for 1 week, then weekly for 4 weeks, then monthly; or 1000-2000 mcg PO daily (effective even in pernicious anemia via passive diffusion); intranasal 500 mcg weekly
| preparations = 100, 250, 500, 1000, 5000 mcg tablets (OTC and Rx); 1000 mcg/mL injection; intranasal spray; sublingual
| fda_max = No strict ceiling; water-soluble vitamin, low toxicity
| pill_id =
| routes = Oral, sublingual, intranasal, IM, SC, IV
| onset = Reticulocyte response at 3-5 days; neurologic recovery weeks to months (and may be incomplete if longstanding)
| duration = N/A (replacement)
| halflife = ~6 days (plasma); hepatic stores last 3-5 years
| bioavailability = Oral ~1-3% via passive diffusion at high doses (independent of intrinsic factor); IM/SC ~100%
| pregnancy = Routinely supplemented in vegan pregnancies and pernicious anemia.{{citation needed}}
| legal = OTC (low/mid-dose oral) and [[USLegal:Prescription only|Rx-only]] (injection, intranasal) in US
| mechanism = <vote slug="cyanocobalamin-mech-claim">Cyanocobalamin is an inactive storage/synthetic form of vitamin B12 that is converted intracellularly to methylcobalamin (cofactor for methionine synthase, regenerating methionine and tetrahydrofolate) and adenosylcobalamin (cofactor for methylmalonyl-CoA mutase, fueling propionyl-CoA / TCA entry).</vote> Failure of either coenzyme produces the characteristic megaloblastic anemia (THF trap) and subacute combined degeneration of dorsal columns and corticospinal tracts. Pernicious anemia is treated with high-dose oral or parenteral B12 because the autoimmune intrinsic factor loss is bypassed by mass-action passive diffusion at supraphysiologic doses.
}}

== References ==
<references />

Cyanocobalamin - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #104