Cyclobenzaprine - Revision history

MDElliottMD: parser-claude: Cyclobenzaprine MedTemplate refill, Top 300 stub upgrade

2026-05-23T06:36:37Z

parser-claude: Cyclobenzaprine MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 06:36, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Cyclobenzaprine		\| generic = Cyclobenzaprine
	\| brand = Flexeril		\| brand = Flexeril (IR; brand discontinued in US, generic widely available), Amrix (ER)
	\| structure =		\| structure =
	\| classes = ~~Muscle~~ relaxant		\| classes = [[:Category:Skeletal muscle relaxants\|Skeletal muscle relaxant (centrally-acting)]], [[:Category:Tricyclic-related compounds\|Tricyclic-related compound]]
	\| ~~mechanism~~ = ~~TCA~~-~~related~~; H1/~~alpha~~/~~muscarinic antagonist~~		\| uses = <vote slug="acute-muscle-spasm-use">Short-term relief of muscle spasm from acute musculoskeletal conditions (FDA; ≤2-3 weeks)</vote>, <vote slug="fibromyalgia-low-dose-use">Fibromyalgia (off-label, low-dose evening)</vote>, <vote slug="insomnia-cyclobenzaprine-use">Insomnia adjunct (off-label, low-dose)</vote>
	\| ~~uses~~ =		\| starting_dose = IR 5 mg PO TID; titrate to 10 mg TID if needed. Amrix ER 15 mg PO once daily. Off-label insomnia / fibromyalgia: 5-10 mg PO at bedtime
	\| ~~starting_dose~~ =		\| preparations = IR tablets 5, 7.5, 10 mg; Amrix ER capsules 15, 30 mg
	\| ~~preparations~~ =		\| fda_max = 30 mg/day (IR or ER)
	\| ~~fda_max~~ =		\| pill_id =
	\| routes =		\| routes = Oral
	\| onset =		\| onset = ~1 hour
	\| duration =		\| duration = 12-24 hours (IR); 24 hours (Amrix ER)
	\| halflife =		\| halflife = 18 hours (IR); 32-33 hours (ER)<ref name="flexeril-label">FDA Prescribing Information, Flexeril (cyclobenzaprine hydrochloride), Merck/various, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017821s048lbl.pdf</ref>
	~~\| bioavailability =~~		\| bioavailability = ~33-55% (IR); reduced by food<ref name="flexeril-label" />
	~~\| pregnancy~~ =		\| pregnancy = Limited human data.{{citation needed}}
	~~\| legal~~ =		\| legal = [[USLegal:Prescription only\|Rx-only]] in US. Not a controlled substance, distinguishing it from the carisoprodol alternative for muscle spasm<ref name="flexeril-label" />
	\| ~~intro =~~		\| mechanism = <vote slug="cyclobenzaprine-mech-claim">Structurally a tricyclic compound closely related to amitriptyline but FDA-approved as a muscle relaxant rather than an antidepressant. Centrally-acting via brainstem and supraspinal sites, reducing tonic somatic motor activity through noradrenergic descending pathways; the spinal cord is not the primary site of action. Substantial anticholinergic, H1 antihistaminergic, and α1-adrenergic antagonist activity accounts for sedation, dry mouth, and orthostatic adverse effects.</vote> '''Serotonin syndrome''' risk applies through the tricyclic-class identity when combined with SSRIs, SNRIs, MAOIs, tramadol, or other serotonergic agents. FDA labeling restricts to short-term use (≤2-3 weeks); evidence for prolonged use is limited<ref name="flexeril-label" />.
	~~\| pharmacokinetics~~ =
	~~\| pharmacodynamics~~ =
	\| ~~indications~~ =
	\| ~~dosing~~ =
	\| ~~effects~~ =
	~~\| interactions = <pharmaInteractions~~/>
	\| ~~pregnancy_details =~~
	~~\| monitoring~~ =
	~~\| counseling~~ =
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references~~ =
	}}		}}

	[[Category:~~Muscle~~ relaxants]]		== References ==
			<references />

			[[Category:Skeletal muscle relaxants]]
			[[Category:Tricyclic-related compounds]]

MDElliottMD: Tier 1 taxonomy consolidation: removed redundant Category:Muscle_Relaxants (canonical already present)

2026-05-21T17:01:53Z

Tier 1 taxonomy consolidation: removed redundant Category:Muscle_Relaxants (canonical already present)

← Older revision		Revision as of 17:01, 21 May 2026
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	[[Category:Muscle relaxants]]		[[Category:Muscle relaxants]]
	~~[[Category:Muscle_Relaxants]]~~

MDElliottMD: Dedupe migration per interface-claude 2026-05-20: Muscle Relaxants (CNS-acting) merged into canonical Muscle relaxants. Member retagged.

2026-05-19T18:00:19Z

Dedupe migration per interface-claude 2026-05-20: Muscle Relaxants (CNS-acting) merged into canonical Muscle relaxants. Member retagged.

← Older revision		Revision as of 18:00, 19 May 2026
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	}}		}}

			[[Category:Muscle relaxants]]
	[[Category:Muscle ~~Relaxants (CNS-acting)~~]]
	[[Category:Muscle_Relaxants]]		[[Category:Muscle_Relaxants]]

MediaWiki default: Assign pharmacological categories from List_of_CNS-active_medicines

2026-05-14T15:07:07Z

Assign pharmacological categories from List_of_CNS-active_medicines

← Older revision		Revision as of 15:07, 14 May 2026
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	}}		}}


			[[Category:Muscle Relaxants (CNS-acting)]]
	[[Category:Muscle_Relaxants]]		[[Category:Muscle_Relaxants]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:30:46Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:30, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:28Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =

MDElliottMD: Added empty fda_max parameter to MedTemplate call

2026-05-13T02:32:55Z

Added empty fda_max parameter to MedTemplate call

← Older revision		Revision as of 02:32, 13 May 2026
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	\| starting_dose =		\| starting_dose =
	\| preparations =		\| preparations =
			\| fda_max =
	\| routes =		\| routes =
	\| onset =		\| onset =
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	[[Category:Muscle_Relaxants]]		[[Category:Muscle_Relaxants]]

MDElliottMD: Expand stub to full MedTemplate parameter set

2026-05-13T01:00:00Z

Expand stub to full MedTemplate parameter set

@@ Line 1: / Line 1: @@
 {{MedTemplate
-| generic           = Cyclobenzaprine
+| generic            = Cyclobenzaprine
-| brand             = Flexeril
+| brand              = Flexeril
-| classes           = Muscle relaxant
+| structure          =
-| mechanism         = TCA-related; H1/alpha/muscarinic antagonist
+| classes            = Muscle relaxant
 }}
 [[Category:Muscle_Relaxants]]

MDElliottMD: Auto-created stub

2026-05-13T00:00:00Z

Auto-created stub

New page

{{MedTemplate
| generic = Cyclobenzaprine
| brand = Flexeril
| classes = Muscle relaxant
| mechanism = TCA-related; H1/alpha/muscarinic antagonist
}}
[[Category:Muscle_Relaxants]]