Cyproheptadine - Revision history

MDElliottMD: parser-claude: Cyproheptadine MedTemplate refill, Top 300 stub upgrade

2026-05-23T07:28:52Z

parser-claude: Cyproheptadine MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 07:28, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Cyproheptadine		\| generic = Cyproheptadine (hydrochloride)
	\| brand = Periactin		\| brand = Periactin (US brand discontinued; generic widely available)
	\| structure =		\| structure =
	\| classes = ~~Antihistamine~~		\| classes = [[:Category:Antihistamines\|First-generation antihistamine]], [[:Category:Serotonin antagonists\|Serotonin 5-HT2 antagonist]], [[:Category:Orexigenics\|Appetite-promoting medicine (orexigenic)]]
	\| ~~mechanism = H1 and~~ 5-HT2 ~~receptor~~ antagonist		\| uses = <vote slug="allergic-conditions-use">Allergic conditions including urticaria and seasonal allergies (FDA)</vote>, <vote slug="serotonin-syndrome-antidote-use">Serotonin syndrome (off-label; the standard pharmacological antidote alongside supportive care and benzodiazepines)</vote>, <vote slug="appetite-stimulation-cachexia-use">Appetite stimulation in failure to thrive, cachexia, and anorexia (off-label, evidence-supported in pediatric and adult populations)</vote>, <vote slug="migraine-prophylaxis-pediatric-use">Pediatric migraine prophylaxis (off-label)</vote>, <vote slug="ssri-sexual-dysfunction-adjunct-use">SSRI-induced sexual dysfunction (off-label adjunct, modest evidence)</vote>
	\| uses =		\| starting_dose = Allergy: 4 mg PO TID. Serotonin syndrome: 12 mg loading dose PO or by nasogastric tube, then 2 mg every 2 hours until clinical improvement. Appetite stimulation: 2-4 mg PO TID-QID
	\| starting_dose =		\| preparations = Tablets 4 mg; oral syrup 2 mg/5 mL
	\| preparations =		\| fda_max = 32 mg/day adult; weight-based pediatric ceiling
	\| fda_max =		\| pill_id =
	\| routes =		\| routes = Oral
	\| onset =		\| onset = 30-60 minutes
	\| duration =		\| duration = 6-8 hours
	\| halflife =		\| halflife = 8-16 hours<ref name="periactin-label">FDA Prescribing Information, Periactin (cyproheptadine hydrochloride), Merck/various, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/010407s058lbl.pdf</ref>
	~~\| bioavailability =~~		\| bioavailability = ~95% (oral)<ref name="periactin-label" />
	~~\| pregnancy~~ =		\| pregnancy = Limited human data; older agent with substantial use experience.{{citation needed}}
	~~\| legal~~ =		\| legal = [[USLegal:Prescription only\|Rx-only]] in US
	\| ~~intro =~~		\| mechanism = <vote slug="cyproheptadine-mech-claim">First-generation H1 histamine receptor antagonist with substantial additional '''5-HT2A and 5-HT2C serotonin receptor antagonism'''. The 5-HT2A antagonism is the basis of its role as the first-line pharmacological antidote for serotonin syndrome; the 5-HT2C antagonism underlies the appetite stimulation effect (the same receptor mechanism that drives weight gain with mirtazapine and olanzapine).</vote> Anticholinergic and sedating, with the standard first-generation antihistamine Beers-list concerns in elderly patients<ref name="periactin-label" />.
	~~\| pharmacokinetics~~ =
	~~\| pharmacodynamics~~ =
	\| ~~indications~~ =
	\| ~~dosing~~ =
	\| ~~effects~~ =
	~~\| interactions~~ = <~~pharmaInteractions~~/>
	~~\| pregnancy_details =~~
	~~\| monitoring =~~
	~~\| counseling =~~
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references~~ =
	}}		}}

			== References ==
			<references />

	[[Category:Antihistamines]]		[[Category:Antihistamines]]
	[[Category:~~First-generation antihistamines~~]]		[[Category:Serotonin antagonists]]
			[[Category:Orexigenics]]

MDElliottMD: Comprehensive categorization: +First-generation antihistamines

2026-05-15T18:42:19Z

Comprehensive categorization: +First-generation antihistamines

← Older revision		Revision as of 18:42, 15 May 2026
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	[[Category:Antihistamines]]		[[Category:Antihistamines]]
			[[Category:First-generation antihistamines]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:30:46Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:30, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:28Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =

MDElliottMD: Added empty fda_max parameter to MedTemplate call

2026-05-13T02:32:56Z

Added empty fda_max parameter to MedTemplate call

← Older revision		Revision as of 02:32, 13 May 2026
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	\| starting_dose =		\| starting_dose =
	\| preparations =		\| preparations =
			\| fda_max =
	\| routes =		\| routes =
	\| onset =		\| onset =
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	[[Category:Antihistamines]]		[[Category:Antihistamines]]

MDElliottMD: Expand stub to full MedTemplate parameter set

2026-05-13T01:00:00Z

Expand stub to full MedTemplate parameter set

@@ Line 1: / Line 1: @@
 {{MedTemplate
-| generic           = Cyproheptadine
+| generic            = Cyproheptadine
-| brand             = Periactin
+| brand              = Periactin
-| classes           = Antihistamine
+| structure          =
-| mechanism         = H1 and 5-HT2 receptor antagonist
+| classes            = Antihistamine
 }}
 [[Category:Antihistamines]]

MDElliottMD: Auto-created stub

2026-05-13T00:00:00Z

Auto-created stub

New page

{{MedTemplate
| generic = Cyproheptadine
| brand = Periactin
| classes = Antihistamine
| mechanism = H1 and 5-HT2 receptor antagonist
}}
[[Category:Antihistamines]]