MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:31Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Tetracycline antibiotics]]
			[[Category:Bacteriostatic antibiotics]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #77

2026-05-23T03:42:09Z

parser-claude batch MedTemplate pre-fill, Top 300 #77

New page

{{MedTemplate
| generic = Doxycycline
| brand = Vibramycin, Doryx, Oracea, Adoxa, Monodox, Acticlate
| structure =
| classes = [[:Category:Tetracycline_antibiotics|Tetracycline antibiotic]], [[:Category:Bacteriostatic_antibiotics|Bacteriostatic antibiotic]]
| uses = <vote slug="cap-use">Community-acquired pneumonia (atypical coverage)</vote>, <vote slug="acne-vulgaris-use">Inflammatory acne</vote>, <vote slug="rosacea-use">Rosacea</vote>, <vote slug="rickettsial-use">Rickettsial infections including Rocky Mountain spotted fever</vote>, <vote slug="lyme-use">Lyme disease</vote>, <vote slug="malaria-prophylaxis-use">Malaria prophylaxis</vote>, <vote slug="doxypep-use">Post-exposure prophylaxis for bacterial STIs (doxy-PEP)</vote>, <vote slug="chlamydia-use">Chlamydia infections</vote>
| starting_dose = 100 mg PO BID; rickettsial 200 mg/d; doxy-PEP 200 mg within 72 hours after condomless sex
| preparations = 50 mg, 75 mg, 100 mg, 150 mg tablets and capsules; delayed-release; suspension; IV
| fda_max = ~200 mg/d for most indications; higher doses for severe infections
| pill_id =
| routes = Oral, IV
| onset = Hours
| duration = 12 hours
| halflife = 16-22 hours<ref name="vibramycin-label">FDA Prescribing Information, Vibramycin (doxycycline), Pfizer, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050006s083lbl.pdf</ref>
| bioavailability = ~95% (oral; reduced by dairy, antacids, iron via divalent-cation chelation, though less than for tetracycline itself)<ref name="vibramycin-label" />
| pregnancy = Avoid in pregnancy and in children <8 years where alternatives exist (dental staining, possible effect on developing bone); life-threatening rickettsial disease is the recognized exception where benefit outweighs.{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = <vote slug="doxycycline-mech-claim">Doxycycline binds reversibly to the 30S bacterial ribosomal subunit and blocks aminoacyl-tRNA from accessing the A site, inhibiting protein synthesis; the resulting effect is bacteriostatic against a broad range of gram-positives, atypicals, spirochetes, and intracellular organisms.</vote> Pleiotropic non-antibiotic effects (matrix metalloproteinase inhibition) underlie efficacy in rosacea and the periodontitis-adjuvant indication at sub-antimicrobial doses. Photosensitivity, pill-induced esophagitis (take with water, remain upright), and esophageal/oral candidiasis are characteristic adverse effects<ref name="vibramycin-label" />.
}}

== References ==
<references />

Doxycycline - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #77