MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:30Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Vitamin D analogs]]
			[[Category:Fat-soluble vitamins]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #48

2026-05-23T03:34:50Z

parser-claude batch MedTemplate pre-fill, Top 300 #48

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{{MedTemplate
| generic = Ergocalciferol (vitamin D2)
| brand = Drisdol, Calcidol; also many OTC preparations
| structure =
| classes = [[:Category:Vitamin_D_analogs|Vitamin D analog]], [[:Category:Fat-soluble_vitamins|Fat-soluble vitamin]]
| uses = <vote slug="vitamin-d-deficiency-use">Vitamin D deficiency</vote>, <vote slug="osteomalacia-use">Osteomalacia</vote>, <vote slug="hypoparathyroidism-use">Hypoparathyroidism (with calcium)</vote>, <vote slug="rickets-use">Nutritional rickets</vote>
| starting_dose = Deficiency: 50,000 IU PO weekly for 8-12 weeks, then maintenance 800-2,000 IU/day; maintenance OTC dosing typically 800-2,000 IU/d
| preparations = 50,000 IU capsules (Rx); 8,000 IU/mL oral solution (Rx); 400-5,000 IU OTC tablets and softgels
| fda_max = Not strictly fixed; long-term Upper Limit ~4,000 IU/d in adults (Institute of Medicine)
| pill_id =
| routes = Oral
| onset = Days to weeks to raise 25(OH)D; clinical effect on bone over months
| duration = Long; fat-soluble, stored in adipose
| halflife = ~24 hours (parent); ~15 days (25(OH)D); 25(OH)D stores persist for months<ref name="drisdol-label">FDA Prescribing Information, Drisdol (ergocalciferol), Sanofi-Aventis, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/006535s029lbl.pdf</ref>
| bioavailability = ~75% (oral; fat-soluble, absorption requires intact biliary/lipid digestion)<ref name="drisdol-label" />
| pregnancy = Safe at replacement doses; deficiency is itself a risk in pregnancy and lactation.{{citation needed}}
| legal = OTC (low-dose) and [[USLegal:Prescription only|Rx-only]] (50,000 IU and concentrated solutions) in US
| mechanism = <vote slug="ergocalciferol-mech-claim">Ergocalciferol (D2) and cholecalciferol (D3) are hydroxylated in the liver by CYP2R1 to 25-hydroxyvitamin D (the storage form measured clinically) and then in the kidney by CYP27B1 to 1,25-dihydroxyvitamin D (calcitriol), the active hormone that binds the vitamin D receptor (VDR) to drive transcription of genes governing intestinal calcium absorption, bone mineralization, and broad immunomodulation.</vote> D3 (cholecalciferol) is more potent at raising serum 25(OH)D per dose; D2 remains widely prescribed in the US Rx 50,000 IU formulation<ref name="drisdol-label" />.
}}

== References ==
<references />

Ergocalciferol - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #48