Fioricet - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:46Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Barbiturates]]
			[[Category:Non-opioid analgesics]]
			[[Category:Methylxanthines]]
			[[Category:Fixed-dose combinations]]

MDElliottMD: home-claude house-rule fix (terminology, Mark ruling)

2026-05-23T04:53:15Z

home-claude house-rule fix (terminology, Mark ruling)

← Older revision		Revision as of 04:53, 23 May 2026
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	\| structure =		\| structure =
	\| classes = [[:Category:Barbiturates\|Barbiturate (butalbital)]], [[:Category:Non-opioid_analgesics\|Non-opioid analgesic (acetaminophen)]], [[:Category:Methylxanthines\|Methylxanthine (caffeine)]], [[:Category:Fixed-dose_combinations\|Fixed-dose combination]]		\| classes = [[:Category:Barbiturates\|Barbiturate (butalbital)]], [[:Category:Non-opioid_analgesics\|Non-opioid analgesic (acetaminophen)]], [[:Category:Methylxanthines\|Methylxanthine (caffeine)]], [[:Category:Fixed-dose_combinations\|Fixed-dose combination]]
	\| uses = <vote slug="tension-headache-use">Tension-type headache (limited evidence; falling out of favor due to ~~medication~~-overuse headache and barbiturate dependence risk)</vote>, <vote slug="migraine-rescue-use">Migraine (off-label, rescue use)</vote>		\| uses = <vote slug="tension-headache-use">Tension-type headache (limited evidence; falling out of favor due to medicine-overuse headache and barbiturate dependence risk)</vote>, <vote slug="migraine-rescue-use">Migraine (off-label, rescue use)</vote>
	\| starting_dose = 1-2 capsules (50 mg butalbital / 325 mg acetaminophen / 40 mg caffeine each) PO every 4 hours as needed; maximum 6 capsules/d		\| starting_dose = 1-2 capsules (50 mg butalbital / 325 mg acetaminophen / 40 mg caffeine each) PO every 4 hours as needed; maximum 6 capsules/d
	\| preparations = 50/325/40 mg capsules and tablets; oral solution		\| preparations = 50/325/40 mg capsules and tablets; oral solution
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	\| pregnancy = Generally avoided; barbiturate exposure in late pregnancy can produce neonatal withdrawal and respiratory depression.{{citation needed}}		\| pregnancy = Generally avoided; barbiturate exposure in late pregnancy can produce neonatal withdrawal and respiratory depression.{{citation needed}}
	\| legal = '''Plain Fioricet is uncontrolled federally''' (the small butalbital dose was historically deemed insufficient for scheduling), but DEA-scheduled in some states. Fioricet with Codeine is [[USLegal:Schedule III\|Schedule III]]. Fiorinal (aspirin instead of acetaminophen) is [[USLegal:Schedule III\|Schedule III]] federally		\| legal = '''Plain Fioricet is uncontrolled federally''' (the small butalbital dose was historically deemed insufficient for scheduling), but DEA-scheduled in some states. Fioricet with Codeine is [[USLegal:Schedule III\|Schedule III]]. Fiorinal (aspirin instead of acetaminophen) is [[USLegal:Schedule III\|Schedule III]] federally
	\| mechanism = <vote slug="fioricet-mech-claim">Butalbital is a short-to-intermediate-acting barbiturate that positively modulates GABA-A receptors, producing sedation and muscle relaxation that may relieve tension-type headache. Acetaminophen provides non-opioid analgesia. Caffeine provides mild vasoconstriction (mechanistically attractive for vasodilatory headache) plus an enhancing effect on analgesic absorption.</vote> Concerns: barbiturate physical dependence with regular use, ~~medication~~-overuse headache (especially with >2 doses/week), and the seemingly persistent absence of high-quality RCT support for the combination's headache efficacy. Modern headache guidelines discourage routine use<ref name="fioricet-label" />.		\| mechanism = <vote slug="fioricet-mech-claim">Butalbital is a short-to-intermediate-acting barbiturate that positively modulates GABA-A receptors, producing sedation and muscle relaxation that may relieve tension-type headache. Acetaminophen provides non-opioid analgesia. Caffeine provides mild vasoconstriction (mechanistically attractive for vasodilatory headache) plus an enhancing effect on analgesic absorption.</vote> Concerns: barbiturate physical dependence with regular use, medicine-overuse headache (especially with >2 doses/week), and the seemingly persistent absence of high-quality RCT support for the combination's headache efficacy. Modern headache guidelines discourage routine use<ref name="fioricet-label" />.
	}}		}}

	== References ==		== References ==
	<references />		<references />

MDElliottMD: parser-claude batch MedTemplate pre-fill, mind-medicine combination

2026-05-23T04:44:11Z

parser-claude batch MedTemplate pre-fill, mind-medicine combination

New page

{{MedTemplate
| generic = Butalbital / Acetaminophen / Caffeine
| brand = Fioricet, Esgic; with codeine as Fioricet with Codeine (Schedule III)
| structure =
| classes = [[:Category:Barbiturates|Barbiturate (butalbital)]], [[:Category:Non-opioid_analgesics|Non-opioid analgesic (acetaminophen)]], [[:Category:Methylxanthines|Methylxanthine (caffeine)]], [[:Category:Fixed-dose_combinations|Fixed-dose combination]]
| uses = <vote slug="tension-headache-use">Tension-type headache (limited evidence; falling out of favor due to medication-overuse headache and barbiturate dependence risk)</vote>, <vote slug="migraine-rescue-use">Migraine (off-label, rescue use)</vote>
| starting_dose = 1-2 capsules (50 mg butalbital / 325 mg acetaminophen / 40 mg caffeine each) PO every 4 hours as needed; maximum 6 capsules/d
| preparations = 50/325/40 mg capsules and tablets; oral solution
| fda_max = 6 capsules/d (300 mg butalbital, 1950 mg acetaminophen, 240 mg caffeine)
| pill_id =
| routes = Oral
| onset = 30-60 minutes
| duration = 4-6 hours
| halflife = Butalbital ~35 hours (long; cumulative effects with frequent use); acetaminophen 1-3 hours; caffeine 3-7 hours<ref name="fioricet-label">FDA Prescribing Information, Fioricet (butalbital / acetaminophen / caffeine), Allergan, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/088762s019lbl.pdf</ref>
| bioavailability = Butalbital well-absorbed; caffeine ~100%; acetaminophen 85-98%<ref name="fioricet-label" />
| pregnancy = Generally avoided; barbiturate exposure in late pregnancy can produce neonatal withdrawal and respiratory depression.{{citation needed}}
| legal = '''Plain Fioricet is uncontrolled federally''' (the small butalbital dose was historically deemed insufficient for scheduling), but DEA-scheduled in some states. Fioricet with Codeine is [[USLegal:Schedule III|Schedule III]]. Fiorinal (aspirin instead of acetaminophen) is [[USLegal:Schedule III|Schedule III]] federally
| mechanism = <vote slug="fioricet-mech-claim">Butalbital is a short-to-intermediate-acting barbiturate that positively modulates GABA-A receptors, producing sedation and muscle relaxation that may relieve tension-type headache. Acetaminophen provides non-opioid analgesia. Caffeine provides mild vasoconstriction (mechanistically attractive for vasodilatory headache) plus an enhancing effect on analgesic absorption.</vote> Concerns: barbiturate physical dependence with regular use, medication-overuse headache (especially with >2 doses/week), and the seemingly persistent absence of high-quality RCT support for the combination's headache efficacy. Modern headache guidelines discourage routine use<ref name="fioricet-label" />.
}}

== References ==
<references />