Fiorinal - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:46Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Barbiturates]]
			[[Category:NSAIDs]]
			[[Category:Methylxanthines]]
			[[Category:Fixed-dose combinations]]
			[[Category:Schedule III controlled substances]]

MDElliottMD: home-claude house-rule fix (terminology, Mark ruling)

2026-05-23T04:53:15Z

home-claude house-rule fix (terminology, Mark ruling)

← Older revision		Revision as of 04:53, 23 May 2026
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	\| structure =		\| structure =
	\| classes = [[:Category:Barbiturates\|Barbiturate (butalbital)]], [[:Category:NSAIDs\|NSAID (aspirin)]], [[:Category:Methylxanthines\|Methylxanthine (caffeine)]], [[:Category:Fixed-dose_combinations\|Fixed-dose combination]], [[:Category:Schedule_III_controlled_substances\|Schedule III controlled substance]]		\| classes = [[:Category:Barbiturates\|Barbiturate (butalbital)]], [[:Category:NSAIDs\|NSAID (aspirin)]], [[:Category:Methylxanthines\|Methylxanthine (caffeine)]], [[:Category:Fixed-dose_combinations\|Fixed-dose combination]], [[:Category:Schedule_III_controlled_substances\|Schedule III controlled substance]]
	\| uses = <vote slug="tension-headache-use">Tension-type headache (limited evidence; falling out of favor due to ~~medication~~-overuse headache and barbiturate dependence risk)</vote>		\| uses = <vote slug="tension-headache-use">Tension-type headache (limited evidence; falling out of favor due to medicine-overuse headache and barbiturate dependence risk)</vote>
	\| starting_dose = 1-2 capsules (50 mg butalbital / 325 mg aspirin / 40 mg caffeine each) PO every 4 hours as needed; maximum 6 capsules/d		\| starting_dose = 1-2 capsules (50 mg butalbital / 325 mg aspirin / 40 mg caffeine each) PO every 4 hours as needed; maximum 6 capsules/d
	\| preparations = 50/325/40 mg capsules		\| preparations = 50/325/40 mg capsules

MDElliottMD: parser-claude housekeeping, em-dash to comma per style rule

2026-05-23T04:45:11Z

parser-claude housekeeping, em-dash to comma per style rule

← Older revision		Revision as of 04:45, 23 May 2026
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	\| bioavailability = Butalbital well-absorbed; aspirin 50-75%; caffeine ~100%<ref name="fiorinal-label" />		\| bioavailability = Butalbital well-absorbed; aspirin 50-75%; caffeine ~100%<ref name="fiorinal-label" />
	\| pregnancy = Avoided; barbiturate + aspirin teratogenicity and bleeding concerns.{{citation needed}}		\| pregnancy = Avoided; barbiturate + aspirin teratogenicity and bleeding concerns.{{citation needed}}
	\| legal = [[USLegal:Schedule III\|Schedule III controlled substance]] in US (Fiorinal is scheduled federally; Fioricet with acetaminophen is unscheduled federally despite identical butalbital content — a regulatory quirk)		\| legal = [[USLegal:Schedule III\|Schedule III controlled substance]] in US (Fiorinal is scheduled federally; Fioricet with acetaminophen is unscheduled federally despite identical butalbital content, a regulatory quirk)
	\| mechanism = <vote slug="fiorinal-mech-claim">Same as Fioricet but with aspirin substituted for acetaminophen as the non-opioid analgesic component. Butalbital positively modulates GABA-A; aspirin provides non-selective COX inhibition with anti-inflammatory effect; caffeine provides vasoconstriction and analgesic-absorption enhancement.</vote> Same concerns as Fioricet plus aspirin GI/bleeding risk; the only practical difference favoring Fiorinal is potential anti-inflammatory benefit in headaches with inflammatory component, though clinical guidance does not differentiate strongly between them<ref name="fiorinal-label" />.		\| mechanism = <vote slug="fiorinal-mech-claim">Same as Fioricet but with aspirin substituted for acetaminophen as the non-opioid analgesic component. Butalbital positively modulates GABA-A; aspirin provides non-selective COX inhibition with anti-inflammatory effect; caffeine provides vasoconstriction and analgesic-absorption enhancement.</vote> Same concerns as Fioricet plus aspirin GI/bleeding risk; the only practical difference favoring Fiorinal is potential anti-inflammatory benefit in headaches with inflammatory component, though clinical guidance does not differentiate strongly between them<ref name="fiorinal-label" />.
	}}		}}

MDElliottMD: parser-claude batch MedTemplate pre-fill, mind-medicine combination

2026-05-23T04:44:11Z

parser-claude batch MedTemplate pre-fill, mind-medicine combination

New page

{{MedTemplate
| generic = Butalbital / Aspirin / Caffeine
| brand = Fiorinal; with codeine as Fiorinal with Codeine (Schedule III)
| structure =
| classes = [[:Category:Barbiturates|Barbiturate (butalbital)]], [[:Category:NSAIDs|NSAID (aspirin)]], [[:Category:Methylxanthines|Methylxanthine (caffeine)]], [[:Category:Fixed-dose_combinations|Fixed-dose combination]], [[:Category:Schedule_III_controlled_substances|Schedule III controlled substance]]
| uses = <vote slug="tension-headache-use">Tension-type headache (limited evidence; falling out of favor due to medication-overuse headache and barbiturate dependence risk)</vote>
| starting_dose = 1-2 capsules (50 mg butalbital / 325 mg aspirin / 40 mg caffeine each) PO every 4 hours as needed; maximum 6 capsules/d
| preparations = 50/325/40 mg capsules
| fda_max = 6 capsules/d (300 mg butalbital, 1950 mg aspirin, 240 mg caffeine)
| pill_id =
| routes = Oral
| onset = 30-60 minutes
| duration = 4-6 hours
| halflife = Butalbital ~35 hours; aspirin (acetyl group) ~15 minutes, salicylate 2-3 hours; caffeine 3-7 hours<ref name="fiorinal-label">FDA Prescribing Information, Fiorinal (butalbital / aspirin / caffeine), Allergan, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/008627s060lbl.pdf</ref>
| bioavailability = Butalbital well-absorbed; aspirin 50-75%; caffeine ~100%<ref name="fiorinal-label" />
| pregnancy = Avoided; barbiturate + aspirin teratogenicity and bleeding concerns.{{citation needed}}
| legal = [[USLegal:Schedule III|Schedule III controlled substance]] in US (Fiorinal is scheduled federally; Fioricet with acetaminophen is unscheduled federally despite identical butalbital content — a regulatory quirk)
| mechanism = <vote slug="fiorinal-mech-claim">Same as Fioricet but with aspirin substituted for acetaminophen as the non-opioid analgesic component. Butalbital positively modulates GABA-A; aspirin provides non-selective COX inhibition with anti-inflammatory effect; caffeine provides vasoconstriction and analgesic-absorption enhancement.</vote> Same concerns as Fioricet plus aspirin GI/bleeding risk; the only practical difference favoring Fiorinal is potential anti-inflammatory benefit in headaches with inflammatory component, though clinical guidance does not differentiate strongly between them<ref name="fiorinal-label" />.
}}

== References ==
<references />