Fluoxetine - Revision history

MDElliottMD: Link legal-status field to the USLegal: namespace

2026-05-22T16:47:33Z

Link legal-status field to the USLegal: namespace

← Older revision		Revision as of 16:47, 22 May 2026
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	\| bioavailability = 70–90% (oral)		\| bioavailability = 70–90% (oral)
	\| pregnancy = Category C<ref name="lactmed">S0</ref>		\| pregnancy = Category C<ref name="lactmed">S0</ref>
	\| legal = Rx-only in US		\| legal = [[USLegal:Prescription only\|Rx-only]] in US
	\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>		\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>
	\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor ([[:Category:Selective_Serotonin_Reuptake_Inhibitors_(SSRIs)\|SSRIs]]) brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.		\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor ([[:Category:Selective_Serotonin_Reuptake_Inhibitors_(SSRIs)\|SSRIs]]) brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.

MDElliottMD: Repoint CYP2D6/CYP3A4 links to the new Enzyme: namespace

2026-05-22T02:57:13Z

Repoint CYP2D6/CYP3A4 links to the new Enzyme: namespace

← Older revision		Revision as of 02:57, 22 May 2026
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	\| pk_absorption = 70–90%<ref name="statpearls">S3</ref> oral bioavailability.		\| pk_absorption = 70–90%<ref name="statpearls">S3</ref> oral bioavailability.
	\| pk_distribution = Fluoxetine has plasma protein binding of approximately 94.5%, bound to albumin and alpha-1 glycoprotein. Fluoxetine readily crosses the blood–brain barrier, with a brain-to-plasma ratio of 2.6:1 in humans. The volume of distribution (Vd) of fluoxetine and its metabolite ranges between 20 to 42 L/kg. Some studies report that fluoxetine has the maximum volume of distribution (Vd) of any SSRI (between 14 and 100 L/kg).<ref name="statpearls"/>		\| pk_distribution = Fluoxetine has plasma protein binding of approximately 94.5%, bound to albumin and alpha-1 glycoprotein. Fluoxetine readily crosses the blood–brain barrier, with a brain-to-plasma ratio of 2.6:1 in humans. The volume of distribution (Vd) of fluoxetine and its metabolite ranges between 20 to 42 L/kg. Some studies report that fluoxetine has the maximum volume of distribution (Vd) of any SSRI (between 14 and 100 L/kg).<ref name="statpearls"/>
	\| pk_metabolism = Fluoxetine's active metabolite is norfluoxetine, produced when the cytochrome P450 enzyme ([[~~Pharmacopedia~~:~~Pharmacogenomics sandbox/Enzyme~~ CYP2D6\|CYP2D6]]) acts on it. Prescribers must remember that fluoxetine has several med-med interactions due to its metabolism through the CYP2D6 isoenzyme. Additionally, norfluoxetine can have an inhibitory effect on [[~~Pharmacopedia~~:~~Pharmacogenomics sandbox/Enzyme~~ CYP3A4\|CYP3A4]]. Fluoxetine has a half-life of 2 to 4 days, and its active metabolite norfluoxetine has a half-life of 7 to 9 days. Approximately 7% of individuals definitively exhibit poor metabolism of fluoxetine due to reduced activity of CYP2D6.<ref name="statpearls"/>		\| pk_metabolism = Fluoxetine's active metabolite is norfluoxetine, produced when the cytochrome P450 enzyme ([[Enzyme:CYP2D6\|CYP2D6]]) acts on it. Prescribers must remember that fluoxetine has several med-med interactions due to its metabolism through the CYP2D6 isoenzyme. Additionally, norfluoxetine can have an inhibitory effect on [[Enzyme:CYP3A4\|CYP3A4]]. Fluoxetine has a half-life of 2 to 4 days, and its active metabolite norfluoxetine has a half-life of 7 to 9 days. Approximately 7% of individuals definitively exhibit poor metabolism of fluoxetine due to reduced activity of CYP2D6.<ref name="statpearls"/>
	\| pk_elimination =		\| pk_elimination =
	\| pharmacodynamics =		\| pharmacodynamics =

MDElliottMD: Internal-linking pass per new rule: link diphenhydramine, CYP2D6/CYP3A4 enzyme pages, venlafaxine, duloxetine, and the infobox class categories

2026-05-21T22:45:24Z

Internal-linking pass per new rule: link diphenhydramine, CYP2D6/CYP3A4 enzyme pages, venlafaxine, duloxetine, and the infobox class categories

← Older revision		Revision as of 22:45, 21 May 2026
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	\| brand = Prozac		\| brand = Prozac
	\| structure = Fluoxwhite.svg		\| structure = Fluoxwhite.svg
	\| classes = SSRI, Anxiolytic, Antidepressant		\| classes = [[:Category:Selective Serotonin Reuptake Inhibitors (SSRIs)\|SSRI]], [[:Category:Anxiolytics\|Anxiolytic]], [[:Category:Antidepressants\|Antidepressant]]
	\| uses = <vote slug="anxiety-use">Anxiety</vote>, <vote slug="premature-ejaculation-use">Premature ejaculation</vote>, <vote slug="low-mood-use">Low mood</vote>		\| uses = <vote slug="anxiety-use">Anxiety</vote>, <vote slug="premature-ejaculation-use">Premature ejaculation</vote>, <vote slug="low-mood-use">Low mood</vote>
	\| starting_dose = 10 mg		\| starting_dose = 10 mg
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	\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>		\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>
	\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor ([[:Category:Selective_Serotonin_Reuptake_Inhibitors_(SSRIs)\|SSRIs]]) brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.		\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor ([[:Category:Selective_Serotonin_Reuptake_Inhibitors_(SSRIs)\|SSRIs]]) brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.
	\| history = The compound that became fluoxetine emerged from an Eli Lilly program that began in the late 1960s under Molloy and Schmiegel, who synthesized a series of aryloxyphenylpropylamines starting from the antihistamine diphenhydramine as a structural lead. Wong, who had followed the European literature implicating serotonin in mood regulation, proposed screening the new compounds specifically for serotonin uptake inhibition. On 24 July 1972 the team identified the compound then designated Lilly 110140 as a potent and selective inhibitor of serotonin uptake in rat brain synaptosomes. The finding was published in 1974 as the first description of what is now known as a selective serotonin reuptake inhibitor.<ref name="wong1974"/>		\| history = The compound that became fluoxetine emerged from an Eli Lilly program that began in the late 1960s under Molloy and Schmiegel, who synthesized a series of aryloxyphenylpropylamines starting from the antihistamine [[Diphenhydramine\|diphenhydramine]] as a structural lead. Wong, who had followed the European literature implicating serotonin in mood regulation, proposed screening the new compounds specifically for serotonin uptake inhibition. On 24 July 1972 the team identified the compound then designated Lilly 110140 as a potent and selective inhibitor of serotonin uptake in rat brain synaptosomes. The finding was published in 1974 as the first description of what is now known as a selective serotonin reuptake inhibitor.<ref name="wong1974"/>

	Lilly renamed the compound fluoxetine in 1975, filed an investigational application with the FDA, and pursued clinical development through the late 1970s and early 1980s. The FDA approved fluoxetine for major depressive disorder in December 1987, and Lilly launched it as Prozac in January 1988. The marketing name itself was a departure: medicines had historically been named to reflect chemical structure, and Prozac was among the first to be commissioned from an outside naming firm. Within five years of launch Prozac was one of the most prescribed medicines in the United States, and Peter Kramer's 1993 book Listening to Prozac made the SSRI era a subject of popular discussion. Lilly's US patent expired in August 2001, after which generic fluoxetine became broadly available.		Lilly renamed the compound fluoxetine in 1975, filed an investigational application with the FDA, and pursued clinical development through the late 1970s and early 1980s. The FDA approved fluoxetine for major depressive disorder in December 1987, and Lilly launched it as Prozac in January 1988. The marketing name itself was a departure: medicines had historically been named to reflect chemical structure, and Prozac was among the first to be commissioned from an outside naming firm. Within five years of launch Prozac was one of the most prescribed medicines in the United States, and Peter Kramer's 1993 book Listening to Prozac made the SSRI era a subject of popular discussion. Lilly's US patent expired in August 2001, after which generic fluoxetine became broadly available.
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	\| pk_absorption = 70–90%<ref name="statpearls">S3</ref> oral bioavailability.		\| pk_absorption = 70–90%<ref name="statpearls">S3</ref> oral bioavailability.
	\| pk_distribution = Fluoxetine has plasma protein binding of approximately 94.5%, bound to albumin and alpha-1 glycoprotein. Fluoxetine readily crosses the blood–brain barrier, with a brain-to-plasma ratio of 2.6:1 in humans. The volume of distribution (Vd) of fluoxetine and its metabolite ranges between 20 to 42 L/kg. Some studies report that fluoxetine has the maximum volume of distribution (Vd) of any SSRI (between 14 and 100 L/kg).<ref name="statpearls"/>		\| pk_distribution = Fluoxetine has plasma protein binding of approximately 94.5%, bound to albumin and alpha-1 glycoprotein. Fluoxetine readily crosses the blood–brain barrier, with a brain-to-plasma ratio of 2.6:1 in humans. The volume of distribution (Vd) of fluoxetine and its metabolite ranges between 20 to 42 L/kg. Some studies report that fluoxetine has the maximum volume of distribution (Vd) of any SSRI (between 14 and 100 L/kg).<ref name="statpearls"/>
	\| pk_metabolism = Fluoxetine's active metabolite is norfluoxetine, produced when the cytochrome P450 enzyme (CYP2D6) acts on it. Prescribers must remember that fluoxetine has several med-med interactions due to its metabolism through the CYP2D6 isoenzyme. Additionally, norfluoxetine can have an inhibitory effect on CYP3A4. Fluoxetine has a half-life of 2 to 4 days, and its active metabolite norfluoxetine has a half-life of 7 to 9 days. Approximately 7% of individuals definitively exhibit poor metabolism of fluoxetine due to reduced activity of CYP2D6.<ref name="statpearls"/>		\| pk_metabolism = Fluoxetine's active metabolite is norfluoxetine, produced when the cytochrome P450 enzyme ([[Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP2D6\|CYP2D6]]) acts on it. Prescribers must remember that fluoxetine has several med-med interactions due to its metabolism through the CYP2D6 isoenzyme. Additionally, norfluoxetine can have an inhibitory effect on [[Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP3A4\|CYP3A4]]. Fluoxetine has a half-life of 2 to 4 days, and its active metabolite norfluoxetine has a half-life of 7 to 9 days. Approximately 7% of individuals definitively exhibit poor metabolism of fluoxetine due to reduced activity of CYP2D6.<ref name="statpearls"/>
	\| pk_elimination =		\| pk_elimination =
	\| pharmacodynamics =		\| pharmacodynamics =
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	\| counseling =		\| counseling =
	\| anecdotes = <anecdote slug="2026-05-12" perspective="provider" author="MDElliottMD">		\| anecdotes = <anecdote slug="2026-05-12" perspective="provider" author="MDElliottMD">
	Fluoxetine is great for getting off other SxRIs! Especially venlafaxine and duloxetine.		Fluoxetine is great for getting off other SxRIs! Especially [[Venlafaxine\|venlafaxine]] and [[Duloxetine\|duloxetine]].
	</anecdote>		</anecdote>
	\| seealso = [[Sertraline]], [[Duloxetine]]		\| seealso = [[Sertraline]], [[Duloxetine]]

MDElliottMD at 22:37, 21 May 2026

2026-05-21T22:37:46Z

← Older revision		Revision as of 22:37, 21 May 2026
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	\| legal = Rx-only in US		\| legal = Rx-only in US
	\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>		\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>
	\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor ([[:Category:Selective_Serotonin_Reuptake_Inhibitors_(SSRIs)\|'SSRIs']]) brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.		\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor ([[:Category:Selective_Serotonin_Reuptake_Inhibitors_(SSRIs)\|SSRIs]]) brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.
	\| history = The compound that became fluoxetine emerged from an Eli Lilly program that began in the late 1960s under Molloy and Schmiegel, who synthesized a series of aryloxyphenylpropylamines starting from the antihistamine diphenhydramine as a structural lead. Wong, who had followed the European literature implicating serotonin in mood regulation, proposed screening the new compounds specifically for serotonin uptake inhibition. On 24 July 1972 the team identified the compound then designated Lilly 110140 as a potent and selective inhibitor of serotonin uptake in rat brain synaptosomes. The finding was published in 1974 as the first description of what is now known as a selective serotonin reuptake inhibitor.<ref name="wong1974"/>		\| history = The compound that became fluoxetine emerged from an Eli Lilly program that began in the late 1960s under Molloy and Schmiegel, who synthesized a series of aryloxyphenylpropylamines starting from the antihistamine diphenhydramine as a structural lead. Wong, who had followed the European literature implicating serotonin in mood regulation, proposed screening the new compounds specifically for serotonin uptake inhibition. On 24 July 1972 the team identified the compound then designated Lilly 110140 as a potent and selective inhibitor of serotonin uptake in rat brain synaptosomes. The finding was published in 1974 as the first description of what is now known as a selective serotonin reuptake inhibitor.<ref name="wong1974"/>

MDElliottMD at 22:37, 21 May 2026

2026-05-21T22:37:14Z

← Older revision		Revision as of 22:37, 21 May 2026
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	\| legal = Rx-only in US		\| legal = Rx-only in US
	\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>		\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>
	\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor ([[Category:Selective_Serotonin_Reuptake_Inhibitors_(SSRIs)\|'SSRIs']]) brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.		\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor ([[:Category:Selective_Serotonin_Reuptake_Inhibitors_(SSRIs)\|'SSRIs']]) brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.
	\| history = The compound that became fluoxetine emerged from an Eli Lilly program that began in the late 1960s under Molloy and Schmiegel, who synthesized a series of aryloxyphenylpropylamines starting from the antihistamine diphenhydramine as a structural lead. Wong, who had followed the European literature implicating serotonin in mood regulation, proposed screening the new compounds specifically for serotonin uptake inhibition. On 24 July 1972 the team identified the compound then designated Lilly 110140 as a potent and selective inhibitor of serotonin uptake in rat brain synaptosomes. The finding was published in 1974 as the first description of what is now known as a selective serotonin reuptake inhibitor.<ref name="wong1974"/>		\| history = The compound that became fluoxetine emerged from an Eli Lilly program that began in the late 1960s under Molloy and Schmiegel, who synthesized a series of aryloxyphenylpropylamines starting from the antihistamine diphenhydramine as a structural lead. Wong, who had followed the European literature implicating serotonin in mood regulation, proposed screening the new compounds specifically for serotonin uptake inhibition. On 24 July 1972 the team identified the compound then designated Lilly 110140 as a potent and selective inhibitor of serotonin uptake in rat brain synaptosomes. The finding was published in 1974 as the first description of what is now known as a selective serotonin reuptake inhibitor.<ref name="wong1974"/>

MDElliottMD at 21:41, 21 May 2026

2026-05-21T21:41:14Z

← Older revision		Revision as of 21:41, 21 May 2026
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	\| legal = Rx-only in US		\| legal = Rx-only in US
	\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>		\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>
	\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor ([[Category:Selective_Serotonin_Reuptake_Inhibitors_(SSRIs)\|SSRIs]]) brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.		\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor ([[Category:Selective_Serotonin_Reuptake_Inhibitors_(SSRIs)\|'SSRIs']]) brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.
	\| history = The compound that became fluoxetine emerged from an Eli Lilly program that began in the late 1960s under Molloy and Schmiegel, who synthesized a series of aryloxyphenylpropylamines starting from the antihistamine diphenhydramine as a structural lead. Wong, who had followed the European literature implicating serotonin in mood regulation, proposed screening the new compounds specifically for serotonin uptake inhibition. On 24 July 1972 the team identified the compound then designated Lilly 110140 as a potent and selective inhibitor of serotonin uptake in rat brain synaptosomes. The finding was published in 1974 as the first description of what is now known as a selective serotonin reuptake inhibitor.<ref name="wong1974"/>		\| history = The compound that became fluoxetine emerged from an Eli Lilly program that began in the late 1960s under Molloy and Schmiegel, who synthesized a series of aryloxyphenylpropylamines starting from the antihistamine diphenhydramine as a structural lead. Wong, who had followed the European literature implicating serotonin in mood regulation, proposed screening the new compounds specifically for serotonin uptake inhibition. On 24 July 1972 the team identified the compound then designated Lilly 110140 as a potent and selective inhibitor of serotonin uptake in rat brain synaptosomes. The finding was published in 1974 as the first description of what is now known as a selective serotonin reuptake inhibitor.<ref name="wong1974"/>

MDElliottMD at 21:40, 21 May 2026

2026-05-21T21:40:18Z

← Older revision		Revision as of 21:40, 21 May 2026
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	\| legal = Rx-only in US		\| legal = Rx-only in US
	\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>		\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>
	\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.		\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor ([[Category:Selective_Serotonin_Reuptake_Inhibitors_(SSRIs)\|SSRIs]]) brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.
	\| history = The compound that became fluoxetine emerged from an Eli Lilly program that began in the late 1960s under Molloy and Schmiegel, who synthesized a series of aryloxyphenylpropylamines starting from the antihistamine diphenhydramine as a structural lead. Wong, who had followed the European literature implicating serotonin in mood regulation, proposed screening the new compounds specifically for serotonin uptake inhibition. On 24 July 1972 the team identified the compound then designated Lilly 110140 as a potent and selective inhibitor of serotonin uptake in rat brain synaptosomes. The finding was published in 1974 as the first description of what is now known as a selective serotonin reuptake inhibitor.<ref name="wong1974"/>		\| history = The compound that became fluoxetine emerged from an Eli Lilly program that began in the late 1960s under Molloy and Schmiegel, who synthesized a series of aryloxyphenylpropylamines starting from the antihistamine diphenhydramine as a structural lead. Wong, who had followed the European literature implicating serotonin in mood regulation, proposed screening the new compounds specifically for serotonin uptake inhibition. On 24 July 1972 the team identified the compound then designated Lilly 110140 as a potent and selective inhibitor of serotonin uptake in rat brain synaptosomes. The finding was published in 1974 as the first description of what is now known as a selective serotonin reuptake inhibitor.<ref name="wong1974"/>

MDElliottMD: Fluoxetine: history-first intro rewrite and new History section (discovery at Eli Lilly 1972, Prozac launch, mechanism note)

2026-05-21T03:34:22Z

Fluoxetine: history-first intro rewrite and new History section (discovery at Eli Lilly 1972, Prozac launch, mechanism note)

← Older revision		Revision as of 03:34, 21 May 2026
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	\| legal = Rx-only in US		\| legal = Rx-only in US
	\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>		\| mechanism = TrkB/BDNF<ref name="trkb">S1</ref> <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote>
	\| intro = Fluoxetine was the first of a ~~long line~~ of ~~SSRIs~~. It is notable for ~~its~~ extremely long half-life and ~~relative lack~~ of ~~withdrawal syndrome~~. It ~~can also be useful~~ in ~~helping taper~~ and ~~discontinue other SxRI meds~~.		\| intro = Fluoxetine, marketed as Prozac, was the first selective serotonin reuptake inhibitor brought to market and the medicine that opened the SSRI era. It was discovered at Eli Lilly's laboratories in Indianapolis on 24 July 1972 by a team that included the chemists Bryan Molloy and Klaus Schmiegel and the pharmacologist David Wong,<ref name="wong1974">Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences. 1974;15(3):471-479. PMID: 4549929.</ref> approved by the FDA in December 1987, and launched in the United States as Prozac in January 1988. It is notable for the extremely long half-life of its active metabolite norfluoxetine, which gives the medicine an unusually mild discontinuation profile and makes it useful as a bridge in tapering patients off shorter-acting serotonergic medicines.
			\| history = The compound that became fluoxetine emerged from an Eli Lilly program that began in the late 1960s under Molloy and Schmiegel, who synthesized a series of aryloxyphenylpropylamines starting from the antihistamine diphenhydramine as a structural lead. Wong, who had followed the European literature implicating serotonin in mood regulation, proposed screening the new compounds specifically for serotonin uptake inhibition. On 24 July 1972 the team identified the compound then designated Lilly 110140 as a potent and selective inhibitor of serotonin uptake in rat brain synaptosomes. The finding was published in 1974 as the first description of what is now known as a selective serotonin reuptake inhibitor.<ref name="wong1974"/>

			Lilly renamed the compound fluoxetine in 1975, filed an investigational application with the FDA, and pursued clinical development through the late 1970s and early 1980s. The FDA approved fluoxetine for major depressive disorder in December 1987, and Lilly launched it as Prozac in January 1988. The marketing name itself was a departure: medicines had historically been named to reflect chemical structure, and Prozac was among the first to be commissioned from an outside naming firm. Within five years of launch Prozac was one of the most prescribed medicines in the United States, and Peter Kramer's 1993 book Listening to Prozac made the SSRI era a subject of popular discussion. Lilly's US patent expired in August 2001, after which generic fluoxetine became broadly available.

			Fluoxetine is a prescription-only medicine in the United States. It remains on the WHO Model List of Essential Medicines and is one of the most widely prescribed serotonergic medicines worldwide. The serotonergic framing under which the medicine was discovered and marketed has not aged uniformly well; the TrkB/BDNF account of its mechanism, developed primarily in the 2000s, is the principal contemporary alternative and is reflected in the mechanism field above.
	\| indications = <problem ref="depression" author="MDElliottMD"/>		\| indications = <problem ref="depression" author="MDElliottMD"/>
	<problem ref="anxiety-disorders" author="MDElliottMD">		<problem ref="anxiety-disorders" author="MDElliottMD">

MDElliottMD: Removed problem "ref-embarrassment" (admin removal)

2026-05-20T23:21:22Z

Removed problem "ref-embarrassment" (admin removal)

← Older revision		Revision as of 23:21, 20 May 2026
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	<problem ref="premature-ejaculation"/>		<problem ref="premature-ejaculation"/>

	~~<problem ref="embarrassment" author="Noob">~~
	~~I was very embarrassed when I told somebody I was using it.~~
	~~</problem>~~
	\| dosing = <titration slug="standard" author="MDElliottMD" title="Standard adult or child">		\| dosing = <titration slug="standard" author="MDElliottMD" title="Standard adult or child">
	Start no higher than 10 mg for the first dose. May increase by 10 mg every 2–12 weeks, or remain at 10 mg if the response is adequate, up to a typical starting maximum of 40 mg. Absolute max: 80 mg.		Start no higher than 10 mg for the first dose. May increase by 10 mg every 2–12 weeks, or remain at 10 mg if the response is adequate, up to a typical starting maximum of 40 mg. Absolute max: 80 mg.

Noob: Added Problem: Embarrassment

2026-05-20T06:40:34Z

Added Problem: Embarrassment

← Older revision		Revision as of 06:40, 20 May 2026
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	<problem ref="premature-ejaculation"/>		<problem ref="premature-ejaculation"/>

			<problem ref="embarrassment" author="Noob">
			I was very embarrassed when I told somebody I was using it.
			</problem>
	\| dosing = <titration slug="standard" author="MDElliottMD" title="Standard adult or child">		\| dosing = <titration slug="standard" author="MDElliottMD" title="Standard adult or child">
	Start no higher than 10 mg for the first dose. May increase by 10 mg every 2–12 weeks, or remain at 10 mg if the response is adequate, up to a typical starting maximum of 40 mg. Absolute max: 80 mg.		Start no higher than 10 mg for the first dose. May increase by 10 mg every 2–12 weeks, or remain at 10 mg if the response is adequate, up to a typical starting maximum of 40 mg. Absolute max: 80 mg.