MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:29Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Corticosteroids]]
			[[Category:Glucocorticoids]]
			[[Category:Inhaled corticosteroids]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #26

2026-05-23T03:34:49Z

parser-claude batch MedTemplate pre-fill, Top 300 #26

New page

{{MedTemplate
| generic = Fluticasone
| brand = Flonase (intranasal, OTC); Flovent (inhaled, asthma); Cutivate (topical)
| structure =
| classes = [[:Category:Corticosteroids|Corticosteroid]], [[:Category:Glucocorticoids|Glucocorticoid]], [[:Category:Inhaled_corticosteroids|Inhaled corticosteroid (ICS)]]
| uses = <vote slug="asthma-controller-use">Asthma controller</vote>, <vote slug="allergic-rhinitis-use">Allergic rhinitis</vote>, <vote slug="copd-use">COPD</vote>, <vote slug="topical-dermatitis-use">Inflammatory dermatoses (topical)</vote>
| starting_dose = Inhaled (Flovent HFA) 88 mcg BID; intranasal (Flonase) 2 sprays/nostril daily; topical (Cutivate) 0.05% cream BID
| preparations = Inhaled MDI 44/110/220 mcg per actuation; DPI (Diskus) 50/100/250 mcg; nasal spray 50 mcg/actuation; cream/ointment 0.005%, 0.05%
| fda_max = ICS 880 mcg/d (asthma); intranasal 200 mcg/d
| pill_id =
| routes = Inhaled, intranasal, topical
| onset = Inhaled: bronchial effect 1-2 weeks; nasal: symptom relief 12-24 hours; topical: hours
| duration = 12-24 hours per dose
| halflife = ~7.8 hours (fluticasone propionate, inhaled systemic exposure)<ref name="flovent-label">FDA Prescribing Information, Flovent HFA (fluticasone propionate), GlaxoSmithKline, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020548s055lbl.pdf</ref>
| bioavailability = <1% oral (extensive first-pass via CYP3A4); ~30% inhaled lung deposition<ref name="flovent-label" />
| pregnancy = Inhaled and intranasal generally considered safe; widely used in asthma in pregnancy.{{citation needed}}
| legal = OTC (intranasal Flonase) and [[USLegal:Prescription only|Rx-only]] (inhaled, topical) in US
| mechanism = <vote slug="fluticasone-mech-claim">Fluticasone is a potent topical glucocorticoid receptor agonist designed for high local receptor affinity and extensive hepatic first-pass to minimize systemic glucocorticoid exposure.</vote> Suppresses inflammatory gene transcription (NF-κB, AP-1), induces lipocortin, downregulates mast cells and eosinophils. CYP3A4 substrate; strong CYP3A4 inhibitors (ritonavir, ketoconazole) can raise systemic levels enough to produce iatrogenic Cushing's<ref name="flovent-label" />.
}}

== References ==
<references />

Fluticasone - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #26