Fluvoxamine - Revision history

MDElliottMD: parser-claude: Fluvoxamine MedTemplate refill, Top 300 stub upgrade

2026-05-23T20:18:54Z

parser-claude: Fluvoxamine MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 20:18, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Fluvoxamine		\| generic = Fluvoxamine (maleate)
	\| brand = Luvox		\| brand = Luvox (US brand discontinued; generic widely available), Luvox CR, Faverin (other markets)
	\| structure =		\| structure =
	\| classes = ~~SSRI, Antidepressant~~		\| classes = [[:Category:SSRIs\|Selective serotonin reuptake inhibitor (SSRI)]], [[:Category:Antidepressants\|Antidepressant]], [[:Category:Anxiolytics\|Anxiolytic]]
	\| ~~mechanism =~~ Selective serotonin reuptake inhibitor		\| uses = <vote slug="ocd-use">Obsessive-compulsive disorder (FDA; '''the first FDA-approved OCD medicine''', 1994)</vote>, <vote slug="social-anxiety-disorder-use">Social anxiety disorder (FDA, Luvox CR)</vote>, <vote slug="major-depressive-disorder-use">Major depressive disorder (off-label in US; FDA in many other markets)</vote>, <vote slug="ptsd-use">Posttraumatic stress disorder (off-label)</vote>, <vote slug="panic-disorder-use">Panic disorder (off-label)</vote>, <vote slug="covid19-outpatient-fluvoxamine-use">COVID-19 outpatient treatment (off-label; TOGETHER trial signal followed by mixed replication, sigma-1 anti-inflammatory rationale)</vote>
	\| uses =		\| starting_dose = 50 mg PO at bedtime; titrate by 50 mg every 4-7 days to clinical effect. Total daily doses >100 mg divided BID. Luvox CR: 100 mg PO once daily, may titrate to 300 mg/day
	\| starting_dose =		\| preparations = IR tablets 25, 50, 100 mg; Luvox CR capsules 100, 150 mg
	\| preparations =		\| fda_max = 300 mg/day (IR or CR)
	\| fda_max =		\| pill_id =
	\| routes =		\| routes = Oral
	\| onset =		\| onset = OCD effect over 1-2 weeks initial, with full effect typically 6-12 weeks; among the slowest SSRIs for OCD response
	\| duration =		\| duration = BID at higher doses (IR); once-daily (CR)
	\| halflife =		\| halflife = ~15 hours (IR)<ref name="luvox-label">FDA Prescribing Information, Luvox CR (fluvoxamine maleate extended-release), Jazz Pharmaceuticals, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021519s019lbl.pdf</ref>
	~~\| bioavailability =~~		\| bioavailability = ~53% (oral)<ref name="luvox-label" />
	~~\| pregnancy~~ =		\| pregnancy = Observational signal for neonatal adaptation syndrome with third-trimester exposure (SSRI class effect).{{citation needed}}
	~~\| legal~~ =		\| legal = [[USLegal:Prescription only\|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults<ref name="luvox-label" />
	\| ~~intro =~~		\| mechanism = <vote slug="fluvoxamine-mech-claim">Selective serotonin reuptake inhibitor with substantial additional '''sigma-1 receptor agonism''' that distinguishes it from other SSRIs. The sigma-1 activity is the proposed mechanism for the off-label COVID-19 outpatient trials and the anti-inflammatory rationale; it may also contribute to the OCD efficacy.</vote> '''Strong CYP1A2 inhibitor''' (the strongest among SSRIs at that isoenzyme), with major interactions: clozapine and theophylline exposure rises substantially; ramelteon and '''tizanidine combinations are contraindicated''' (~30-fold tizanidine exposure increase with severe hypotension reported); olanzapine, mexiletine, and caffeine all require attention. Also significant CYP2C19 and CYP3A4 inhibition. CPIC PGx guidance applies for CYP2C19<ref name="cpic-ssri">CPIC Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors, 2023. https://cpicpgx.org/guidelines/guideline-for-selective-serotonin-reuptake-inhibitors-and-cyp2d6-and-cyp2c19/</ref>.
	~~\| pharmacokinetics~~ =
	~~\| pharmacodynamics~~ =
	\| ~~indications~~ =
	\| ~~dosing~~ =
	\| ~~effects =~~
	~~\| interactions~~ = ~~<pharmaInteractions~~/>
	\| ~~pregnancy_details =~~
	~~\| monitoring~~ =
	~~\| counseling~~ =
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references~~ =
	}}		}}

			== References ==
			<references />

	[[Category:~~Selective Serotonin Reuptake Inhibitors (~~SSRIs)]]		[[Category:SSRIs]]
	[[Category:Antidepressants]]		[[Category:Antidepressants]]
			[[Category:Anxiolytics]]

MediaWiki default: Assign pharmacological categories from List_of_CNS-active_medicines

2026-05-14T15:06:48Z

Assign pharmacological categories from List_of_CNS-active_medicines

← Older revision		Revision as of 15:06, 14 May 2026
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	}}		}}


			[[Category:Selective Serotonin Reuptake Inhibitors (SSRIs)]]
	[[Category:Antidepressants]]		[[Category:Antidepressants]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:30:53Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:30, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:35Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =

MDElliottMD: Added empty fda_max parameter to MedTemplate call

2026-05-13T02:32:36Z

Added empty fda_max parameter to MedTemplate call

← Older revision		Revision as of 02:32, 13 May 2026
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	\| starting_dose =		\| starting_dose =
	\| preparations =		\| preparations =
			\| fda_max =
	\| routes =		\| routes =
	\| onset =		\| onset =
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	[[Category:Antidepressants]]		[[Category:Antidepressants]]

MDElliottMD: Expand stub to full MedTemplate parameter set

2026-05-13T01:00:00Z

Expand stub to full MedTemplate parameter set

@@ Line 1: / Line 1: @@
 {{MedTemplate
-| generic           = Fluvoxamine
+| generic            = Fluvoxamine
-| brand             = Luvox
+| brand              = Luvox
-| classes           = SSRI, Antidepressant
+| structure          =
-| mechanism         = Selective serotonin reuptake inhibitor
+| classes            = SSRI, Antidepressant
 }}
 [[Category:Antidepressants]]

MDElliottMD: Auto-created stub

2026-05-13T00:00:00Z

Auto-created stub

New page

{{MedTemplate
| generic = Fluvoxamine
| brand = Luvox
| classes = SSRI, Antidepressant
| mechanism = Selective serotonin reuptake inhibitor
}}
[[Category:Antidepressants]]