Hydroxyzine - Revision history

MDElliottMD: parser-claude: Hydroxyzine MedTemplate refill, Top 300 stub upgrade

2026-05-23T06:32:24Z

parser-claude: Hydroxyzine MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 06:32, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Hydroxyzine		\| generic = Hydroxyzine (hydrochloride; pamoate salt)
	\| brand = Vistaril		\| brand = Vistaril (pamoate), Atarax (HCl, discontinued in US as brand)
	\| structure =		\| structure =
	\| classes = Anxiolytic, ~~Antihistamine~~		\| classes = [[:Category:Antihistamines\|First-generation antihistamine]], [[:Category:Anxiolytics\|Anxiolytic]], [[:Category:Antipruritics\|Antipruritic]], [[:Category:Sleep aids\|Sleep aid (off-label)]]
	\| ~~mechanism = H1 antagonist; also 5~~-~~HT2A antagonist~~		\| uses = <vote slug="anxiety-short-term-use">Anxiety symptoms (FDA, short-term)</vote>, <vote slug="pruritus-allergic-use">Pruritus from allergic conditions (FDA)</vote>, <vote slug="preoperative-sedation-use">Preoperative sedation (FDA)</vote>, <vote slug="nausea-vomiting-im-use">Nausea and vomiting (FDA, IM only)</vote>, <vote slug="insomnia-hydroxyzine-use">Insomnia (off-label)</vote>, <vote slug="alcohol-withdrawal-adjunct-use">Acute alcohol withdrawal adjunct (off-label)</vote>, <vote slug="pediatric-agitation-use">Pediatric acute agitation (off-label)</vote>
	\| uses =		\| starting_dose = Anxiety: 25-50 mg PO QID. Pruritus: 25 mg PO TID-QID. Insomnia: 25-50 mg PO at bedtime. Pediatric: 50-100 mg/day divided
	\| starting_dose =		\| preparations = Tablets 10, 25, 50 mg (HCl); capsules 25, 50, 100 mg (pamoate); oral suspension 25 mg/5 mL; injection 25, 50 mg/mL (IM only, never IV)
	\| preparations =		\| fda_max = 400 mg/day theoretical; in practice rarely exceeds 200 mg/day
	\| fda_max =		\| pill_id =
	\| routes =		\| routes = Oral, intramuscular
	\| onset =		\| onset = 15-30 minutes (oral)
	\| duration =		\| duration = 4-6 hours
	\| halflife =		\| halflife = 14-25 hours (longer in elderly and hepatic impairment)<ref name="vistaril-label">FDA Prescribing Information, Vistaril (hydroxyzine pamoate), Pfizer, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/011459s045lbl.pdf</ref>
	~~\| bioavailability =~~		\| bioavailability = ~80% (oral)<ref name="vistaril-label" />
	~~\| pregnancy~~ =		\| pregnancy = Limited human data; older agent with substantial use experience; some signal for first-trimester exposure but not conclusive.{{citation needed}}
	~~\| legal~~ =		\| legal = [[USLegal:Prescription only\|Rx-only]] in US. Not a controlled substance, which is a meaningful clinical advantage over the benzodiazepine alternatives for short-term anxiety<ref name="vistaril-label" />
	\| ~~intro =~~		\| mechanism = <vote slug="hydroxyzine-mech-claim">First-generation H1 histamine receptor antagonist with central nervous system penetration producing sedation. Additional 5-HT2A receptor antagonism, α1-adrenergic antagonism, and anticholinergic effects contribute to the sedative, anxiolytic, and antiemetic activity. Crucially, hydroxyzine has '''no GABA receptor activity''', so it carries no tolerance to anxiolytic effect, no withdrawal syndrome, no dependence liability, and no controlled-substance status, distinguishing it sharply from the benzodiazepine alternatives.</vote> '''QT prolongation''' risk at high doses prompted the FDA's 2015 caution against use in patients with prolonged QT or with concurrent QT-prolonging medicines<ref name="vistaril-label" />.
	~~\| pharmacokinetics~~ =
	~~\| pharmacodynamics~~ =
	\| ~~indications~~ =
	\| ~~dosing~~ =
	\| ~~effects~~ =
	~~\| interactions = <pharmaInteractions~~/>
	\| ~~pregnancy_details =~~
	~~\| monitoring~~ =
	~~\| counseling~~ =
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references~~ =
	}}		}}

			== References ==
			<references />

	[[Category:~~Sedative-hypnotics~~]]		[[Category:Antihistamines]]
	[[Category:Anxiolytics]]		[[Category:Anxiolytics]]
	[[Category:~~Antihistamines~~]]		[[Category:Antipruritics]]
	[[Category:~~First-generation antihistamines~~]]		[[Category:Sleep aids]]

MDElliottMD: Category taxonomy ship: retag Sedative-Hypnotics -> Sedative-hypnotics

2026-05-22T00:36:41Z

Category taxonomy ship: retag Sedative-Hypnotics -> Sedative-hypnotics

← Older revision		Revision as of 00:36, 22 May 2026
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	[[Category:Sedative-~~Hypnotics~~]]		[[Category:Sedative-hypnotics]]
	[[Category:Anxiolytics]]		[[Category:Anxiolytics]]
	[[Category:Antihistamines]]		[[Category:Antihistamines]]
	[[Category:First-generation antihistamines]]		[[Category:First-generation antihistamines]]

MDElliottMD: Tier 2 taxonomy consolidation: add Category:Sedative-Hypnotics; remove retired Category:Anxiolytics & Sedative-Hypnotics

2026-05-21T17:44:49Z

Tier 2 taxonomy consolidation: add Category:Sedative-Hypnotics; remove retired Category:Anxiolytics & Sedative-Hypnotics

← Older revision		Revision as of 17:44, 21 May 2026
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	[[Category:~~Anxiolytics &~~ Sedative-Hypnotics]]		[[Category:Sedative-Hypnotics]]
	[[Category:Anxiolytics]]		[[Category:Anxiolytics]]
	[[Category:Antihistamines]]		[[Category:Antihistamines]]
	[[Category:First-generation antihistamines]]		[[Category:First-generation antihistamines]]

MDElliottMD: Comprehensive categorization: +Antihistamines, First-generation antihistamines

2026-05-15T18:42:19Z

Comprehensive categorization: +Antihistamines, First-generation antihistamines

← Older revision		Revision as of 18:42, 15 May 2026
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	[[Category:Anxiolytics & Sedative-Hypnotics]]		[[Category:Anxiolytics & Sedative-Hypnotics]]
	[[Category:Anxiolytics]]		[[Category:Anxiolytics]]
			[[Category:Antihistamines]]
			[[Category:First-generation antihistamines]]

MediaWiki default: Assign pharmacological categories from List_of_CNS-active_medicines

2026-05-14T15:06:53Z

Assign pharmacological categories from List_of_CNS-active_medicines

← Older revision		Revision as of 15:06, 14 May 2026
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	}}		}}


			[[Category:Anxiolytics & Sedative-Hypnotics]]
	[[Category:Anxiolytics]]		[[Category:Anxiolytics]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:30:54Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:30, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:36Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =

MDElliottMD: Added empty fda_max parameter to MedTemplate call

2026-05-13T02:32:43Z

Added empty fda_max parameter to MedTemplate call

← Older revision		Revision as of 02:32, 13 May 2026
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	\| starting_dose =		\| starting_dose =
	\| preparations =		\| preparations =
			\| fda_max =
	\| routes =		\| routes =
	\| onset =		\| onset =
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	[[Category:Anxiolytics]]		[[Category:Anxiolytics]]

MDElliottMD: Expand stub to full MedTemplate parameter set

2026-05-13T01:00:00Z

Expand stub to full MedTemplate parameter set

@@ Line 1: / Line 1: @@
 {{MedTemplate
-| generic           = Hydroxyzine
+| generic            = Hydroxyzine
-| brand             = Vistaril
+| brand              = Vistaril
-| classes           = Anxiolytic, Antihistamine
+| structure          =
-| mechanism         = H1 antagonist; also 5-HT2A antagonist
+| classes            = Anxiolytic, Antihistamine
 }}
 [[Category:Anxiolytics]]

MDElliottMD: Auto-created stub

2026-05-13T00:00:00Z

Auto-created stub

New page

{{MedTemplate
| generic = Hydroxyzine
| brand = Vistaril
| classes = Anxiolytic, Antihistamine
| mechanism = H1 antagonist; also 5-HT2A antagonist
}}
[[Category:Anxiolytics]]