https://pharmacopedia.wiki/index.php?action=history&feed=atom&title=Indomethacin
Indomethacin - Revision history
2026-05-28T12:10:54Z
Revision history for this page on the wiki
MediaWiki 1.46.0-beta
https://pharmacopedia.wiki/index.php?title=Indomethacin&diff=6733&oldid=prev
MDElliottMD: parser-claude: Indomethacin MedTemplate refill, Top 300 stub upgrade
2026-05-23T07:33:36Z
<p>parser-claude: Indomethacin MedTemplate refill, Top 300 stub upgrade</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 07:33, 23 May 2026</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{Stub}}</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{MedTemplate</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{MedTemplate</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>| generic = Indomethacin</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>| generic <ins style="font-weight: bold; text-decoration: none;"> </ins>= Indomethacin</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>| brand <del style="font-weight: bold; text-decoration: none;"> </del>= Indocin</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>| brand <ins style="font-weight: bold; text-decoration: none;"> </ins>= Indocin <ins style="font-weight: bold; text-decoration: none;">(oral, IV, suppository), Tivorbex (low-dose), Indo-Lemmon</ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>| classes = NSAID</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| structure =</ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>| <del style="font-weight: bold; text-decoration: none;">intro </del>= <del style="font-weight: bold; text-decoration: none;">Indomethacin </del>is a <del style="font-weight: bold; text-decoration: none;">potent non</del>-<del style="font-weight: bold; text-decoration: none;">selective non</del>-<del style="font-weight: bold; text-decoration: none;">steroidal anti</del>-<del style="font-weight: bold; text-decoration: none;">inflammatory drug </del>(<del style="font-weight: bold; text-decoration: none;">NSAID</del>), <del style="font-weight: bold; text-decoration: none;">used </del>for <del style="font-weight: bold; text-decoration: none;">inflammatory conditions such as </del>gout and <del style="font-weight: bold; text-decoration: none;">certain forms </del>of <del style="font-weight: bold; text-decoration: none;">arthritis</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>| classes <ins style="font-weight: bold; text-decoration: none;"> </ins>= <ins style="font-weight: bold; text-decoration: none;">[[:Category:NSAIDs|Non-steroidal anti-inflammatory (</ins>NSAID<ins style="font-weight: bold; text-decoration: none;">, potent non-selective)]], [[:Category:Analgesics|Analgesic]]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>| <ins style="font-weight: bold; text-decoration: none;">uses = <vote slug="acute-gouty-arthritis-use">Acute gouty arthritis (FDA; the classic first-line indication)</vote>, <vote slug="rheumatoid-arthritis-use">Moderate-to-severe rheumatoid arthritis (FDA)</vote>, <vote slug="osteoarthritis-use">Osteoarthritis (FDA)</vote>, <vote slug="ankylosing-spondylitis-use">Ankylosing spondylitis (FDA)</vote>, <vote slug="pseudogout-use">Calcium pyrophosphate deposition disease (pseudogout, off-label)</vote>, <vote slug</ins>=<ins style="font-weight: bold; text-decoration: none;">"acute-migraine-indomethacin-use">Acute migraine and hemicrania continua (off-label; the latter </ins>is a <ins style="font-weight: bold; text-decoration: none;">uniquely indomethacin</ins>-<ins style="font-weight: bold; text-decoration: none;">responsive headache syndrome)</vote>, <vote slug="pda</ins>-<ins style="font-weight: bold; text-decoration: none;">closure</ins>-<ins style="font-weight: bold; text-decoration: none;">use">Patent ductus arteriosus closure in preterm neonates </ins>(<ins style="font-weight: bold; text-decoration: none;">FDA, IV; Indocin IV</ins>)<ins style="font-weight: bold; text-decoration: none;"></vote></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| starting_dose = Acute gout: 50 mg PO TID until symptom relief, then taper; maximum 200 mg/day for 3-5 days. Rheumatoid arthritis / osteoarthritis: 25-50 mg PO BID-TID. Patent ductus arteriosus: 0.2 mg/kg IV</ins>, <ins style="font-weight: bold; text-decoration: none;">then 0.1-0.2 mg/kg every 12-24 hours </ins>for <ins style="font-weight: bold; text-decoration: none;">2 doses</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| preparations = Capsules 25, 50 mg; ER capsules 75 mg; oral suspension 25 mg/5 mL; suppositories 50 mg; injection 1 mg/vial (PDA closure)</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| fda_max = 200 mg/day (typical adult oral)</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| pill_id =</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| routes = Oral, rectal, intravenous (PDA closure only)</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| onset = 30-60 minutes (oral); rapid relief in acute </ins>gout</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| duration = 4-6 hours (IR); 24 hours (ER)</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| halflife = 4-5 hours<ref name="indocin-label">FDA Prescribing Information, Indocin (indomethacin), Iroko/Egalet, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018332s044lbl.pdf</ref></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| bioavailability = ~100% (oral)<ref name="indocin-label" /></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| pregnancy = Avoid from 20 weeks gestation onward per FDA's 2020 expanded NSAID warning; contraindicated from 30 weeks (risk of premature ductus arteriosus closure, which is paradoxically the basis of the neonatal PDA-closure indication)<ref name="indocin-label" /></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| legal = [[USLegal:Prescription only|Rx-only]] in US</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| mechanism = <vote slug="indomethacin-mech-claim">Non-selective COX-1 </ins>and <ins style="font-weight: bold; text-decoration: none;">COX-2 inhibitor with '''high potency''' relative to other NSAIDs, the basis </ins>of <ins style="font-weight: bold; text-decoration: none;">its acute-gout efficacy and the uniquely indomethacin-responsive hemicrania continua syndrome. The PDA closure indication uses prostaglandin inhibition therapeutically: the ductus arteriosus stays patent via prostaglandin E1, and inhibiting its synthesis closes the shunt.</vote> Among the higher-cardiovascular-risk NSAIDs, with elevated GI bleeding risk compared to the class average. Notable for '''CNS adverse effects''' uncommon with other NSAIDs: paradoxical headache, dizziness, depression, and confusion in elderly patients (Beers-list concerns)<ref name="indocin-label" /></ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== References ==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><references /></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:NSAIDs]]</ins></div></td></tr>
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MDElliottMD
https://pharmacopedia.wiki/index.php?title=Indomethacin&diff=4488&oldid=prev
MDElliottMD: Create stub for Indomethacin (linked from Category:NSAIDs Members section)
2026-05-18T02:50:04Z
<p>Create stub for Indomethacin (linked from Category:NSAIDs Members section)</p>
<p><b>New page</b></p><div>{{Stub}}<br />
{{MedTemplate<br />
| generic = Indomethacin<br />
| brand = Indocin<br />
| classes = NSAID<br />
| intro = Indomethacin is a potent non-selective non-steroidal anti-inflammatory drug (NSAID), used for inflammatory conditions such as gout and certain forms of arthritis.<br />
}}</div>
MDElliottMD