MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:41Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Antiparasitics]]
			[[Category:Macrocyclic lactones]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #295

2026-05-23T04:08:53Z

parser-claude batch MedTemplate pre-fill, Top 300 #295

New page

{{MedTemplate
| generic = Ivermectin
| brand = Stromectol (oral, generic), Sklice (lice, topical), Soolantra (rosacea, topical 1%)
| structure =
| classes = [[:Category:Antiparasitics|Antiparasitic]], [[:Category:Macrocyclic_lactones|Macrocyclic lactone (avermectin)]]
| uses = <vote slug="strongyloidiasis-use">Strongyloidiasis</vote>, <vote slug="onchocerciasis-use">Onchocerciasis (river blindness)</vote>, <vote slug="scabies-use">Scabies (including crusted/Norwegian scabies)</vote>, <vote slug="head-lice-use">Head lice (topical Sklice)</vote>, <vote slug="rosacea-use">Inflammatory rosacea (topical Soolantra)</vote>, <vote slug="lymphatic-filariasis-use">Lymphatic filariasis (combination)</vote>
| starting_dose = Strongyloides 200 mcg/kg PO single dose; scabies 200 mcg/kg PO repeated at 7-14 days; onchocerciasis 150 mcg/kg q6-12 months
| preparations = 3 mg tablets (Stromectol); 0.5% topical lotion (Sklice); 1% topical cream (Soolantra)
| fda_max = Single 200-400 mcg/kg per dose for systemic indications
| pill_id =
| routes = Oral, topical
| onset = Hours to days
| duration = Variable
| halflife = ~16-18 hours<ref name="stromectol-label">FDA Prescribing Information, Stromectol (ivermectin), Merck, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050742s026lbl.pdf</ref>
| bioavailability = ~60% (oral; substantially increased with high-fat meal)<ref name="stromectol-label" />
| pregnancy = Limited data; risk-benefit case by case; pregnancy is not a strict contraindication in WHO mass drug administration programs.{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US (the veterinary preparations are not for human use)
| mechanism = <vote slug="ivermectin-mech-claim">Ivermectin binds invertebrate glutamate-gated chloride channels (and to a lesser extent GABA-gated channels) in nerve and muscle cells of parasites, opening the channels and producing hyperpolarization and paralysis; mammalian neurons lack the equivalent channel, and P-glycoprotein at the mammalian blood-brain barrier excludes the drug from the CNS, accounting for the wide safety margin in humans.</vote> Substantially more concentrated topical formulations (Soolantra 1%) exploit local anti-inflammatory and antiparasitic effects against Demodex in rosacea. P-glycoprotein loss-of-function (rare in humans, common in some collie dog breeds) produces severe CNS toxicity<ref name="stromectol-label" />.
}}

== References ==
<references />

Ivermectin - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #295