MDElliottMD: home-claude punt-list stub, Top 300 #289

2026-05-23T04:41:14Z

home-claude punt-list stub, Top 300 #289

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Lactated Ringer's solution (LR; called Hartmann's solution outside North America) is a balanced isotonic crystalloid intravenous fluid containing sodium, potassium, calcium, chloride, and lactate (as sodium lactate) in concentrations approximating extracellular fluid<ref name="lr-label">FDA Prescribing Information, Lactated Ringer's Injection, Baxter, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/016659s041lbl.pdf</ref>. It is one of the most widely administered IV fluids in surgery, trauma, sepsis, and burns; the lactate component is metabolized hepatically to bicarbonate, providing a mild alkalinizing buffer. Compared with normal saline, LR causes less hyperchloremic metabolic acidosis at high volumes.

{{MedTemplate
| generic = Lactated Ringer's solution
| brand = Lactated Ringer's Injection (Baxter, B. Braun, ICU Medical); Hartmann's solution (intl.)
| structure =
| classes = [[:Category:Crystalloid_IV_fluids|Crystalloid IV fluid]], [[:Category:Electrolyte_replacements|Electrolyte replacement]]
| uses = <vote slug="volume-resuscitation-use">Volume resuscitation</vote>, <vote slug="perioperative-fluid-use">Perioperative maintenance fluid</vote>, <vote slug="trauma-resuscitation-use">Trauma and burn resuscitation</vote>, <vote slug="sepsis-resuscitation-use">Sepsis resuscitation</vote>
| starting_dose = Volume titrated to clinical status; typical adult bolus 500-1000 mL, then reassess
| preparations = 250, 500, 1000 mL IV bags. Composition per liter: Na+ 130 mEq, K+ 4 mEq, Ca2+ 3 mEq, Cl- 109 mEq, lactate 28 mEq
| fda_max = No fixed maximum; titrated to clinical endpoints
| pill_id =
| routes = IV
| onset = Immediate intravascular expansion
| duration = Roughly 20-30% remains intravascular at 1 hour
| halflife = Not applicable (electrolyte solution)
| bioavailability = 100% (IV)
| pregnancy = Standard resuscitation fluid in pregnancy
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = <vote slug="lr-mech-claim">Lactated Ringer's expands the extracellular volume isotonically; its electrolyte composition is closer to plasma than 0.9% saline, and the lactate is metabolized to bicarbonate by the liver, providing a mild alkalinizing buffer and avoiding the hyperchloremic metabolic acidosis that high-volume saline can produce.</vote> Calcium content is a relative contraindication for co-administration with citrated blood products through the same line<ref name="lr-label" />.
}}

== References ==
<references />

Lactated Ringer's solution - Revision history

MDElliottMD: home-claude punt-list stub, Top 300 #289