MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:40Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Osmotic laxatives]]
			[[Category:Disaccharides]]
			[[Category:Hepatic encephalopathy treatments]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #266

2026-05-23T04:08:52Z

parser-claude batch MedTemplate pre-fill, Top 300 #266

New page

{{MedTemplate
| generic = Lactulose
| brand = Kristalose, Constulose, Generlac, Enulose
| structure =
| classes = [[:Category:Osmotic_laxatives|Osmotic laxative]], [[:Category:Disaccharides|Non-absorbable disaccharide]], [[:Category:Hepatic_encephalopathy_treatments|Hepatic encephalopathy treatment]]
| uses = <vote slug="chronic-constipation-use">Chronic constipation</vote>, <vote slug="hepatic-encephalopathy-use">Hepatic encephalopathy (acute and chronic)</vote>
| starting_dose = Constipation: 15-30 mL PO daily (titrate to 1-2 soft stools/day); hepatic encephalopathy: 20-30 g (30-45 mL) PO/PR every 1-2 hours acutely until soft stools, then BID-QID to target 2-3 soft stools/day
| preparations = 10 g/15 mL solution (Constulose); 10 g, 20 g powder packets (Kristalose)
| fda_max = Indication-specific; HE may require high-volume dosing
| pill_id =
| routes = Oral, rectal (enema, especially in acute HE)
| onset = Constipation: 24-48 hours; HE: ammonia reduction within hours of stool production
| duration = Hours
| halflife = Not meaningfully described — lactulose is not significantly absorbed
| bioavailability = <3% systemic absorption (the basis of the safety and mechanism)<ref name="kristalose-label">FDA Prescribing Information, Kristalose (lactulose), Mission Pharmacal, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020706s015lbl.pdf</ref>
| pregnancy = Generally considered safe (minimal systemic absorption).{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = <vote slug="lactulose-mech-claim">Lactulose is a non-absorbable synthetic disaccharide (galactose-fructose) that passes intact to the colon where bacterial fermentation produces short-chain fatty acids, lowering luminal pH and trapping ammonia as non-absorbable ammonium ion (NH₄⁺); the same fermentation also produces an osmotic load that draws water into the lumen, softening stool.</vote> In hepatic encephalopathy, both mechanisms (ammonia trapping AND laxation that purges nitrogenous waste from the gut) contribute to ammonia reduction. Cathartic flatulence is the universal side effect; dehydration with overuse can paradoxically precipitate HE<ref name="kristalose-label" />.
}}

== References ==
<references />

Lactulose - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #266