MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:27Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Thyroid hormones]]
			[[Category:Hormone replacement]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #3

2026-05-23T03:25:35Z

parser-claude batch MedTemplate pre-fill, Top 300 #3

New page

{{MedTemplate
| generic = Levothyroxine
| brand = Synthroid, Levoxyl, Tirosint, Unithroid, Euthyrox
| structure =
| classes = [[:Category:Thyroid_hormones|Thyroid hormone]], [[:Category:Hormone_replacement|Hormone replacement]]
| uses = <vote slug="hypothyroidism-use">Hypothyroidism</vote>, <vote slug="goiter-use">Goiter</vote>, <vote slug="thyroid-cancer-suppression-use">TSH suppression in thyroid cancer</vote>
| starting_dose = 1.6 mcg/kg/d in young healthy adults; 25-50 mcg/d in elderly or cardiac disease, titrated by TSH at 6-8 weeks
| preparations = 25, 50, 75, 88, 100, 112, 125, 137, 150, 175, 200, 300 mcg tablets; oral capsule and IV/IM also available
| fda_max = No fixed maximum; titrated to TSH target
| pill_id =
| routes = Oral, IV
| onset = TSH normalization 4-8 weeks; symptomatic improvement weeks to months
| duration = Steady-state at 4-6 weeks
| halflife = ~7 days (euthyroid); longer in hypothyroidism (~9-10 days), shorter in hyperthyroidism<ref name="synthroid-label">FDA Prescribing Information, Synthroid (levothyroxine sodium), AbbVie, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021402s032lbl.pdf</ref>
| bioavailability = 40-80% (oral); reduced by food, calcium, iron, PPIs, fiber; take fasting with water<ref name="synthroid-label" />
| pregnancy = First-line in pregnancy; dose typically increased 25-30% due to estrogen-driven rise in TBG and fetal demand. Lactation safe at physiologic doses.{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = Synthetic T4 (thyroxine); peripherally deiodinated to T3 (triiodothyronine), the active hormone. <vote slug="levothyroxine-mech-claim">Levothyroxine binds nuclear thyroid hormone receptors to drive transcription of genes governing basal metabolic rate, thermogenesis, cardiac inotropy, lipid handling, and bone turnover.</vote> Narrow therapeutic index; brand-to-generic switches can shift TSH and require re-titration<ref name="synthroid-label" />.
}}

== References ==
<references />

Levothyroxine - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #3