Lisdexamfetamine - Revision history

MDElliottMD: parser-claude: Lisdexamfetamine MedTemplate refill, Top 300 stub upgrade

2026-05-23T06:48:33Z

parser-claude: Lisdexamfetamine MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 06:48, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Lisdexamfetamine		\| generic = Lisdexamfetamine (dimesylate)
	\| brand = Vyvanse		\| brand = Vyvanse, Elvanse (EU)
	\| structure =		\| structure =
	\| classes = Amphetamine, ~~Psychostimulant~~		\| classes = [[:Category:Psychostimulants\|Psychostimulant]], [[:Category:Amphetamines\|Amphetamine]], [[:Category:ADHD medicines\|ADHD medicine]], [[:Category:Schedule II controlled substances\|Schedule II controlled substance]]
	\| ~~mechanism = Prodrug of dextroamphetamine~~		\| uses = <vote slug="adhd-lisdex-use">Attention-deficit/hyperactivity disorder (FDA, ages 6+ and adult)</vote>, <vote slug="binge-eating-disorder-use">Binge-eating disorder in adults (FDA)</vote>
	\| uses =		\| starting_dose = ADHD: 30 mg PO once daily in the morning; titrate by 10-20 mg weekly to clinical effect. Binge-eating disorder: 30 mg/day, titrate to 50-70 mg/day
	\| starting_dose =		\| preparations = Capsules 10, 20, 30, 40, 50, 60, 70 mg; chewable tablets 10, 20, 30, 40, 50, 60 mg
	\| preparations =		\| fda_max = 70 mg/day
	\| fda_max =		\| pill_id =
	\| routes =		\| routes = Oral
	\| onset =		\| onset = 1-2 hours (slower than immediate-release amphetamine because activation requires enzymatic cleavage in red blood cells)
	\| duration =		\| duration = 10-12 hours (smoother profile than immediate-release amphetamine salts)
	\| halflife =		\| halflife = Parent lisdexamfetamine <1 hour; dextroamphetamine 10-12 hours after release<ref name="vyvanse-label">FDA Prescribing Information, Vyvanse (lisdexamfetamine dimesylate), Takeda/Shire, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021977s045lbl.pdf</ref>
	~~\| bioavailability =~~		\| bioavailability = ~96% after red blood cell hydrolytic cleavage releases dextroamphetamine<ref name="vyvanse-label" />
	~~\| pregnancy~~ =		\| pregnancy = Limited human data; the amphetamine class is associated with intrauterine growth restriction and neonatal withdrawal symptoms.{{citation needed}}
	~~\| legal~~ =		\| legal = [[USLegal:Schedule II\|Schedule II controlled substance]] in US<ref name="vyvanse-label" />
	\| ~~intro =~~		\| mechanism = <vote slug="lisdexamfetamine-mech-claim">Lisdexamfetamine is an inactive lysine-conjugated parent compound that requires enzymatic cleavage by red blood cell hydrolases to release active dextroamphetamine. The red-blood-cell-dependent conversion provides a slower, smoother release profile than immediate-release amphetamine salts, and is the basis of the abuse-deterrent design: IV administration bypasses the necessary RBC cleavage and produces no peak effect, and intranasal misuse offers little kinetic advantage over oral administration.</vote> Once converted, dextroamphetamine acts by displacing dopamine and norepinephrine from presynaptic vesicles via VMAT-2 and reversing DAT and NET transport, the shared mechanism of all amphetamine-class agents<ref name="vyvanse-label" />.
	~~\| pharmacokinetics~~ =
	~~\| pharmacodynamics~~ =
	\| ~~indications~~ =
	\| ~~dosing~~ =
	\| ~~effects =~~
	~~\| interactions~~ = ~~<pharmaInteractions~~/>
	\| ~~pregnancy_details =~~
	~~\| monitoring~~ =
	~~\| counseling~~ =
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references~~ =
	}}		}}

			== References ==
			<references />

	[[Category:Psychostimulants]]		[[Category:Psychostimulants]]
	[[Category:Amphetamines]]		[[Category:Amphetamines]]
	[[Category:~~Psychostimulants~~]]		[[Category:ADHD medicines]]
			[[Category:Schedule II controlled substances]]

MDElliottMD: Recategorize: Stimulants -> Psychostimulants

2026-05-17T10:50:47Z

Recategorize: Stimulants -> Psychostimulants

← Older revision		Revision as of 10:50, 17 May 2026
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	[[Category:~~Stimulants~~]]		[[Category:Psychostimulants]]
	[[Category:Amphetamines]]		[[Category:Amphetamines]]
	[[Category:Psychostimulants]]		[[Category:Psychostimulants]]

MDElliottMD: Recategorize: Stimulants & Wake-Promoting Agents -> Stimulants

2026-05-17T10:44:59Z

Recategorize: Stimulants & Wake-Promoting Agents -> Stimulants

← Older revision		Revision as of 10:44, 17 May 2026
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	[[Category:Stimulants ~~& Wake-Promoting Agents~~]]		[[Category:Stimulants]]
	[[Category:Amphetamines]]		[[Category:Amphetamines]]
	[[Category:Psychostimulants]]		[[Category:Psychostimulants]]

MediaWiki default: Assign pharmacological categories from List_of_CNS-active_medicines

2026-05-14T15:06:54Z

Assign pharmacological categories from List_of_CNS-active_medicines

← Older revision		Revision as of 15:06, 14 May 2026
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	}}		}}


			[[Category:Stimulants & Wake-Promoting Agents]]
			[[Category:Amphetamines]]
	[[Category:Psychostimulants]]		[[Category:Psychostimulants]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:30:56Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:30, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:39Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =

MDElliottMD: Added empty fda_max parameter to MedTemplate call

2026-05-13T02:32:43Z

Added empty fda_max parameter to MedTemplate call

← Older revision		Revision as of 02:32, 13 May 2026
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	\| starting_dose =		\| starting_dose =
	\| preparations =		\| preparations =
			\| fda_max =
	\| routes =		\| routes =
	\| onset =		\| onset =
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	[[Category:Psychostimulants]]		[[Category:Psychostimulants]]

MDElliottMD: Expand stub to full MedTemplate parameter set

2026-05-13T01:00:00Z

Expand stub to full MedTemplate parameter set

@@ Line 1: / Line 1: @@
 {{MedTemplate
-| generic           = Lisdexamfetamine
+| generic            = Lisdexamfetamine
-| brand             = Vyvanse
+| brand              = Vyvanse
-| classes           = Amphetamine, Psychostimulant
+| structure          =
-| mechanism         = Prodrug of dextroamphetamine
+| classes            = Amphetamine, Psychostimulant
 }}
 [[Category:Psychostimulants]]

MDElliottMD: Auto-created stub

2026-05-13T00:00:00Z

Auto-created stub

New page

{{MedTemplate
| generic = Lisdexamfetamine
| brand = Vyvanse
| classes = Amphetamine, Psychostimulant
| mechanism = Prodrug of dextroamphetamine
}}
[[Category:Psychostimulants]]