MDElliottMD: Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved.

2026-05-19T03:16:09Z

Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved.

← Older revision		Revision as of 03:16, 19 May 2026
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	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring = Heart rate, blood pressure; in HFrEF, watch for fluid retention during titration.		\| monitoring = Heart rate, blood pressure; in HFrEF, watch for fluid retention during titration.
	\| counseling = Do not stop abruptly. Tartrate and succinate are NOT interchangeable mg-for-mg — succinate is once-daily and the only form proven in HF trials.		\| counseling = Do not stop abruptly. Tartrate and succinate are NOT interchangeable mg-for-mg, succinate is once-daily and the only form proven in HF trials.
	\| anecdotes =		\| anecdotes =
	\| seealso = [[Propranolol]], [[Bisoprolol]], [[Nebivolol]]		\| seealso = [[Propranolol]], [[Bisoprolol]], [[Nebivolol]]

MDElliottMD: Create Metoprolol scaffold

2026-05-15T07:15:40Z

Create Metoprolol scaffold

New page

{{MedTemplate
| generic = Metoprolol
| brand = Lopressor (tartrate), Toprol XL (succinate)
| classes = Beta Blocker, Cardioselective (β1)
| uses = <vote slug="hypertension-use">Hypertension</vote>, <vote slug="angina-use">Angina</vote>, <vote slug="post-mi-use">Post-MI cardioprotection</vote>, <vote slug="heart-failure-use">Heart failure (succinate only)</vote>, <vote slug="svt-use">SVT</vote>
| starting_dose = 25–50 mg BID (tartrate); 25–100 mg daily (succinate); 12.5 mg daily in HFrEF
| preparations = Tartrate: 25, 50, 100 mg tabs; 1 mg/mL IV. Succinate ER: 25, 50, 100, 200 mg.
| fda_max = 400 mg/d
| routes = Oral, IV
| onset = 1–2 h (PO); immediate (IV)
| duration = 6–12 h (tartrate); 24 h (succinate)
| halflife = 3–7 h
| bioavailability = ~50%
| pregnancy = Category C
| legal = Rx-only in US
| mechanism = Cardioselective β1-adrenergic antagonist. Selectivity is dose-dependent and partially lost at higher doses.
| intro = Metoprolol is a cardioselective (β1-preferring) beta blocker that comes in two salt forms: tartrate (short-acting, BID dosing) and succinate (extended-release, once-daily, and the only form approved for heart failure with reduced ejection fraction). Cardioselectivity makes it a reasonable first-line option in patients with mild reactive airway disease, though β2 effects emerge at higher doses.
| indications =
| dosing =
| effects =
| pk_absorption = ~50% oral bioavailability.
| pk_distribution = Modest plasma protein binding (~12%). Some CNS penetration but less than propranolol.
| pk_metabolism = Hepatic via CYP2D6. Poor metabolizers have higher exposure and more pronounced effect.
| pk_elimination = Renal excretion of metabolites.
| pharmacodynamics =
| interactions = <pharmaInteractions/>
| pregnancy_details =
| monitoring = Heart rate, blood pressure; in HFrEF, watch for fluid retention during titration.
| counseling = Do not stop abruptly. Tartrate and succinate are NOT interchangeable mg-for-mg — succinate is once-daily and the only form proven in HF trials.
| anecdotes =
| seealso = [[Propranolol]], [[Bisoprolol]], [[Nebivolol]]
| references = <references/>
}}

[[Category:Beta Blockers]]
[[Category:Medicines]]

Metoprolol - Revision history

MDElliottMD: Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved.

MDElliottMD: Create Metoprolol scaffold