MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:37Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Nitrates]]
			[[Category:Vasodilators]]
			[[Category:Antianginals]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #207

2026-05-23T04:00:15Z

parser-claude batch MedTemplate pre-fill, Top 300 #207

New page

{{MedTemplate
| generic = Nitroglycerin (glyceryl trinitrate, GTN)
| brand = Nitrostat, Nitrolingual, NitroMist, Nitro-Bid, Nitro-Dur, Minitran, Rectiv
| structure =
| classes = [[:Category:Nitrates|Organic nitrate]], [[:Category:Vasodilators|Vasodilator]], [[:Category:Antianginals|Antianginal]]
| uses = <vote slug="acute-angina-use">Acute angina relief (SL, lingual spray)</vote>, <vote slug="angina-prophylaxis-use">Angina prophylaxis (oral ER, transdermal)</vote>, <vote slug="acute-cardiac-pulmonary-edema-use">Acute cardiogenic pulmonary edema (IV)</vote>, <vote slug="hypertensive-emergency-use">Hypertensive emergency (IV)</vote>, <vote slug="anal-fissure-use">Chronic anal fissure (topical Rectiv 0.4%)</vote>
| starting_dose = SL 0.3-0.6 mg every 5 minutes up to 3 doses for acute angina (call EMS if not resolved after the third); IV infusion 5-10 mcg/min titrated; transdermal patch 0.2-0.4 mg/hr for 12-14 hours daily (nitrate-free interval prevents tolerance)
| preparations = SL 0.3, 0.4, 0.6 mg tablets; lingual spray 0.4 mg/spray; ER 2.5-9 mg capsules; transdermal patch 0.1-0.8 mg/hr; 2% ointment; 0.4% rectal ointment; 5 mg/mL IV
| fda_max = Indication-specific; titrated to effect
| pill_id =
| routes = Sublingual, lingual spray, oral ER, transdermal, topical, rectal, IV
| onset = SL/spray: 1-3 minutes; IV: minutes; patch: 30-60 minutes
| duration = SL: 30 minutes; patch: 12-14 hours; IV continuous
| halflife = 1-3 minutes (very short)<ref name="nitrostat-label">FDA Prescribing Information, Nitrostat (nitroglycerin sublingual tablets), Pfizer, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021134s006lbl.pdf</ref>
| bioavailability = Highly route-dependent: SL bypasses first-pass; oral has extensive first-pass (used only for chronic ER preparations); transdermal predictable<ref name="nitrostat-label" />
| pregnancy = Used in obstetric emergencies (uterine relaxation, severe hypertension) when needed; otherwise limited routine use.{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = <vote slug="nitroglycerin-mech-claim">Nitroglycerin is enzymatically denitrated (largely by mitochondrial aldehyde dehydrogenase, ALDH2) to release nitric oxide (NO), which activates soluble guanylyl cyclase, raises cGMP, and relaxes vascular smooth muscle predominantly in the venous capacitance bed (preload reduction) at low doses, with arterial vasodilation at higher doses.</vote> '''Phosphodiesterase-5 inhibitors''' (sildenafil, tadalafil, vardenafil) catastrophically potentiate nitrate-induced hypotension — concurrent use is absolutely contraindicated. Tolerance develops rapidly with continuous exposure; daily nitrate-free intervals (typically 8-12 hours) restore responsiveness<ref name="nitrostat-label" />.
}}

== References ==
<references />

Nitroglycerin - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #207