MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:38Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Polyene antifungals]]
			[[Category:Antifungals]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #233

2026-05-23T04:04:20Z

parser-claude batch MedTemplate pre-fill, Top 300 #233

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{{MedTemplate
| generic = Nystatin
| brand = Mycostatin, Nystop, Nyamyc, Bio-Statin
| structure =
| classes = [[:Category:Polyene_antifungals|Polyene antifungal]], [[:Category:Antifungals|Antifungal]]
| uses = <vote slug="oropharyngeal-candidiasis-use">Oropharyngeal candidiasis (oral suspension swish-and-swallow)</vote>, <vote slug="cutaneous-candidiasis-use">Cutaneous candidiasis</vote>, <vote slug="vulvovaginal-candidiasis-use">Vulvovaginal candidiasis</vote>, <vote slug="intestinal-candidiasis-use">Intestinal candidiasis (non-absorbable oral tablet)</vote>
| starting_dose = Oral: 4-6 mL (400,000-600,000 units) suspension QID swish-and-swallow; topical: BID-QID; vaginal tablet 1 daily for 2 weeks
| preparations = 100,000 units/mL oral suspension; 500,000 unit tablets; 100,000 units/g cream, ointment, powder; vaginal tablets
| fda_max = Indication-specific
| pill_id =
| routes = Oral (topical action; minimal systemic absorption), topical, vaginal
| onset = Symptom relief within days
| duration = Hours per application
| halflife = Not meaningfully described (not systemically absorbed)<ref name="mycostatin-label">FDA Prescribing Information, nystatin oral suspension, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050425s055lbl.pdf</ref>
| bioavailability = Essentially zero systemic absorption from oral or topical routes — the topical-action-only profile is the basis of its safety<ref name="mycostatin-label" />
| pregnancy = Generally considered safe in pregnancy (no systemic absorption).{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = <vote slug="nystatin-mech-claim">Nystatin is a polyene antifungal that binds ergosterol in fungal cell membranes, forming transmembrane pores that disrupt ionic homeostasis and cause cell death; selectivity comes from preferential affinity for ergosterol (fungi) over cholesterol (mammalian membranes).</vote> Same mechanistic family as amphotericin B but with prohibitive systemic toxicity at therapeutic doses, hence restriction to topical and luminal-gut indications. No clinically meaningful resistance after decades of use<ref name="mycostatin-label" />.
}}

== References ==
<references />

Nystatin - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #233