MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:45Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Fluoroquinolones]]
			[[Category:Antibacterials]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #169

2026-05-23T04:21:35Z

parser-claude batch MedTemplate pre-fill, Top 300 #169

New page

{{MedTemplate
| generic = Ofloxacin
| brand = Floxin (oral, US brand discontinued); Ocuflox (ophthalmic); Floxin Otic (otic)
| structure =
| classes = [[:Category:Fluoroquinolones|Fluoroquinolone antibiotic]], [[:Category:Antibacterials|Antibacterial]]
| uses = <vote slug="bacterial-conjunctivitis-use">Bacterial conjunctivitis/keratitis (ophthalmic)</vote>, <vote slug="otitis-externa-use">Otitis externa</vote>, <vote slug="otitis-media-tympanostomy-use">Acute otitis media with tympanostomy tubes (otic)</vote>, <vote slug="complicated-uti-use">Complicated UTI / pyelonephritis (oral; declining use)</vote>, <vote slug="bacterial-prostatitis-use">Bacterial prostatitis (oral)</vote>
| starting_dose = Oral 200-400 mg BID; ophthalmic 1-2 drops in affected eye(s) q2-4h initially, then taper; otic 5-10 drops in affected ear BID
| preparations = 200, 300, 400 mg tablets (mostly generic now); 0.3% ophthalmic solution; 0.3% otic solution
| fda_max = 800 mg/d
| pill_id =
| routes = Oral, ophthalmic, otic
| onset = Hours
| duration = 12 hours
| halflife = ~9 hours<ref name="floxin-label">FDA Prescribing Information, Floxin (ofloxacin), Janssen, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019735s058lbl.pdf</ref>
| bioavailability = ~95% (oral)<ref name="floxin-label" />
| pregnancy = '''Avoid in pregnancy where alternatives exist''' (animal cartilage toxicity; class-wide concern).{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US. Carries the same fluoroquinolone-class '''Boxed Warnings''' as ciprofloxacin/levofloxacin<ref name="floxin-label" />
| mechanism = <vote slug="ofloxacin-mech-claim">Ofloxacin (racemic; the L-enantiomer levofloxacin is marketed separately and accounts for most antibacterial activity) inhibits bacterial DNA gyrase and topoisomerase IV, blocking DNA replication; the racemic form has fallen out of routine systemic use as levofloxacin's purified L-enantiomer supplanted it.</vote> Topical ophthalmic and otic formulations remain widely used in ENT and ophthalmology. Subject to all fluoroquinolone-class restrictions (tendinitis/rupture, peripheral neuropathy, QT prolongation)<ref name="floxin-label" />.
}}

== References ==
<references />

Ofloxacin - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #169