Onabotulinumtoxin A - Revision history

MDElliottMD: Category taxonomy ship: retag Migraine Medicines -> Antimigraine agents

2026-05-22T00:37:09Z

Category taxonomy ship: retag Migraine Medicines -> Antimigraine agents

← Older revision		Revision as of 00:37, 22 May 2026
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	[[Category:~~Migraine Medicines~~]]		[[Category:Antimigraine agents]]
	[[Category:Neurotoxins]]		[[Category:Neurotoxins]]

MDElliottMD: Sweep: "indications" -> "problems" sitewide terminology update (preserves MedTemplate param name)

2026-05-19T01:37:45Z

Sweep: "indications" -> "problems" sitewide terminology update (preserves MedTemplate param name)

← Older revision		Revision as of 01:37, 19 May 2026
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	\| classes = Neurotoxin, neuromuscular blocker (presynaptic)		\| classes = Neurotoxin, neuromuscular blocker (presynaptic)
	\| mechanism = Cleaves SNAP-25 protein in presynaptic motor and autonomic nerve terminals, blocking acetylcholine release; in chronic migraine, hypothesized to inhibit peripheral sensitization of trigeminovascular nociceptors		\| mechanism = Cleaves SNAP-25 protein in presynaptic motor and autonomic nerve terminals, blocking acetylcholine release; in chronic migraine, hypothesized to inhibit peripheral sensitization of trigeminovascular nociceptors
	\| uses = Chronic migraine (≥15 headache days/month), cervical dystonia, blepharospasm, hyperhidrosis, overactive bladder, urinary incontinence, strabismus, spasticity, cosmetic ~~indications~~		\| uses = Chronic migraine (≥15 headache days/month), cervical dystonia, blepharospasm, hyperhidrosis, overactive bladder, urinary incontinence, strabismus, spasticity, cosmetic problems
	\| starting_dose = Chronic migraine (PREEMPT protocol): 155 units divided across 31 sites in 7 head/neck muscle groups every 12 weeks		\| starting_dose = Chronic migraine (PREEMPT protocol): 155 units divided across 31 sites in 7 head/neck muscle groups every 12 weeks
	\| preparations = 50, 100, or 200 unit vials of lyophilized powder for reconstitution		\| preparations = 50, 100, or 200 unit vials of lyophilized powder for reconstitution
	\| fda_max = 195 units/treatment for chronic migraine; max varies by ~~indication~~		\| fda_max = 195 units/treatment for chronic migraine; max varies by problem
	\| routes = Intramuscular (PREEMPT injections for migraine)		\| routes = Intramuscular (PREEMPT injections for migraine)
	\| onset = 1–2 weeks for muscle effects; preventive migraine benefit accrues over 12-week cycles		\| onset = 1–2 weeks for muscle effects; preventive migraine benefit accrues over 12-week cycles

Maintenance script: Create Onabotulinumtoxin A page

2026-05-15T22:50:06Z

Create Onabotulinumtoxin A page

New page

{{MedTemplate
| brand = Botox
| classes = Neurotoxin, neuromuscular blocker (presynaptic)
| mechanism = Cleaves SNAP-25 protein in presynaptic motor and autonomic nerve terminals, blocking acetylcholine release; in chronic migraine, hypothesized to inhibit peripheral sensitization of trigeminovascular nociceptors
| uses = Chronic migraine (≥15 headache days/month), cervical dystonia, blepharospasm, hyperhidrosis, overactive bladder, urinary incontinence, strabismus, spasticity, cosmetic indications
| starting_dose = Chronic migraine (PREEMPT protocol): 155 units divided across 31 sites in 7 head/neck muscle groups every 12 weeks
| preparations = 50, 100, or 200 unit vials of lyophilized powder for reconstitution
| fda_max = 195 units/treatment for chronic migraine; max varies by indication
| routes = Intramuscular (PREEMPT injections for migraine)
| onset = 1–2 weeks for muscle effects; preventive migraine benefit accrues over 12-week cycles
| duration = ~12 weeks
| halflife = Tissue half-life not formally measured; clinical effect ~12 weeks
| bioavailability = Local (intramuscular)
| pregnancy = Category C; limited data
| legal = Rx; black-box warning for distant spread of toxin effect
| intro = '''Onabotulinumtoxin A''' (brand name Botox) is a purified neurotoxin derived from ''Clostridium botulinum''. FDA-approved in 2010 for chronic migraine prophylaxis (≥15 headache days/month, ≥8 of which are migraine), administered via the PREEMPT injection protocol across 31 fixed sites in head and neck musculature every 12 weeks.
}}

[[Category:Migraine Medicines]]
[[Category:Neurotoxins]]