Oxcarbazepine - Revision history

MDElliottMD: parser-claude: Oxcarbazepine MedTemplate refill, Top 300 stub upgrade

2026-05-23T07:24:02Z

parser-claude: Oxcarbazepine MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 07:24, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Oxcarbazepine		\| generic = Oxcarbazepine
	\| brand = Trileptal		\| brand = Trileptal (IR), Oxtellar XR
	\| structure =		\| structure =
	\| classes = Mood ~~Stabilizer~~, ~~Anticonvulsant~~		\| classes = [[:Category:Anticonvulsants\|Anticonvulsant]], [[:Category:Mood stabilizers\|Mood stabilizer (off-label)]], [[:Category:Sodium channel blockers\|Sodium channel blocker]]
	\| ~~mechanism =~~ Sodium channel blocker		\| uses = <vote slug="partial-seizures-monotherapy-use">Partial-onset seizures (FDA, adult monotherapy and adjunct, pediatric ≥2)</vote>, <vote slug="trigeminal-neuralgia-use">Trigeminal neuralgia (off-label, often preferred over carbamazepine for better tolerability)</vote>, <vote slug="bipolar-disorder-oxcarbazepine-use">Bipolar I disorder (off-label, similar utility to carbamazepine)</vote>
	\| uses =		\| starting_dose = Adult monotherapy: 300 mg PO BID, titrate by 300 mg every 3 days. Pediatric: weight-based titration starting 8-10 mg/kg/day divided BID
	\| starting_dose =		\| preparations = IR tablets 150, 300, 600 mg; oral suspension 60 mg/mL; XR tablets 150, 300, 600 mg (Oxtellar)
	\| preparations =		\| fda_max = 2400 mg/day (adult)
	\| fda_max =		\| pill_id =
	\| routes =		\| routes = Oral
	\| onset =		\| onset = Anticonvulsant effect within days at therapeutic plasma level
	\| duration =		\| duration = BID dosing (IR); once-daily (XR)
	\| halflife =		\| halflife = Oxcarbazepine 2 hours; '''10-monohydroxy active metabolite (MHD) ~9 hours''' (the agent that produces essentially all of the clinical effect)<ref name="trileptal-label">FDA Prescribing Information, Trileptal (oxcarbazepine), Novartis, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021014s036lbl.pdf</ref>
	\| bioavailability =		\| bioavailability = ~100% (oral)<ref name="trileptal-label" />
	\| pregnancy =		\| pregnancy = Teratogenic signal less than carbamazepine but present; folate supplementation and effective contraception are appropriate in reproductive-age patients<ref name="trileptal-label" />
	\| legal =		\| legal = [[USLegal:Prescription only\|Rx-only]] in US
	\| ~~intro =~~		\| mechanism = <vote slug="oxcarbazepine-mech-claim">The 10-monohydroxy active metabolite (MHD) is the clinically active species, a voltage-gated sodium channel blocker in the inactivated state. Compared to its parent compound carbamazepine, oxcarbazepine has '''substantially less CYP3A4 autoinduction''', fewer cytochrome-mediated interactions, no clinically significant aplastic anemia or agranulocytosis signal, and a cleaner overall tolerability profile.</vote> '''Retains the HLA-B15:02 cross-sensitivity''' of carbamazepine for Stevens-Johnson syndrome and toxic epidermal necrolysis risk in Asian populations; CPIC and FDA recommend pre-treatment HLA-B15:02 testing. '''Hyponatremia''' is more common than with carbamazepine, particularly in elderly patients; sodium monitoring during titration is standard<ref name="cpic-hla">CPIC Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine, 2017. https://cpicpgx.org/guidelines/guideline-for-carbamazepine-and-hla-b/</ref>.
	\| ~~pharmacokinetics~~ =
	~~\| pharmacodynamics~~ =
	~~\| indications =~~
	~~\| dosing =~~
	~~\| effects =~~
	\| interactions = <~~pharmaInteractions~~/>
	~~\| pregnancy_details =~~
	\| monitoring =
	~~\| counseling =~~
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references~~ =
	}}		}}

			== References ==
			<references />

			[[Category:Anticonvulsants]]
	[[Category:Mood stabilizers]]		[[Category:Mood stabilizers]]
	[[Category:Sodium channel blockers]]		[[Category:Sodium channel blockers]]
	~~[[Category:Antiepileptics]]~~
	~~[[Category:Mood stabilizers]]~~

CategoryClaude: Sentence-case category link fixup (drop residual Mood_Stabilizers)

2026-05-23T05:05:03Z

Sentence-case category link fixup (drop residual Mood_Stabilizers)

← Older revision		Revision as of 05:05, 23 May 2026
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	}}		}}

	[[Category:~~Mood_Stabilizers~~]]		[[Category:Mood stabilizers]]
	[[Category:Sodium channel blockers]]		[[Category:Sodium channel blockers]]
	[[Category:Antiepileptics]]		[[Category:Antiepileptics]]
	[[Category:Mood stabilizers]]		[[Category:Mood stabilizers]]

CategoryClaude: Sentence-case category link per house style (Mood_Stabilizers → Mood_stabilizers)

2026-05-23T05:02:20Z

Sentence-case category link per house style (Mood_Stabilizers → Mood_stabilizers)

← Older revision		Revision as of 05:02, 23 May 2026
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	[[Category:Sodium channel blockers]]		[[Category:Sodium channel blockers]]
	[[Category:Antiepileptics]]		[[Category:Antiepileptics]]
	[[Category:Mood ~~Stabilizers~~]]		[[Category:Mood stabilizers]]

MDElliottMD: Category taxonomy ship: retag Anticonvulsants -> Antiepileptics

2026-05-22T00:37:11Z

Category taxonomy ship: retag Anticonvulsants -> Antiepileptics

← Older revision		Revision as of 00:37, 22 May 2026
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	[[Category:Mood_Stabilizers]]		[[Category:Mood_Stabilizers]]
	[[Category:Sodium channel blockers]]		[[Category:Sodium channel blockers]]
	[[Category:~~Anticonvulsants~~]]		[[Category:Antiepileptics]]
	[[Category:Mood Stabilizers]]		[[Category:Mood Stabilizers]]

MDElliottMD: Dedupe migration per interface-claude 2026-05-20: Anticonvulsants / Antiepileptics merged into canonical Anticonvulsants. Member retagged.

2026-05-19T18:00:14Z

Dedupe migration per interface-claude 2026-05-20: Anticonvulsants / Antiepileptics merged into canonical Anticonvulsants. Member retagged.

← Older revision		Revision as of 18:00, 19 May 2026
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	[[Category:Mood_Stabilizers]]		[[Category:Mood_Stabilizers]]
	[[Category:Sodium channel blockers]]		[[Category:Sodium channel blockers]]
	[[Category:Anticonvulsants ~~/ Antiepileptics~~]]		[[Category:Anticonvulsants]]
	[[Category:Mood Stabilizers]]		[[Category:Mood Stabilizers]]

MDElliottMD: Comprehensive categorization: +Sodium channel blockers, Anticonvulsants / Antiepileptics, Mood Stabilizers

2026-05-15T18:42:09Z

Comprehensive categorization: +Sodium channel blockers, Anticonvulsants / Antiepileptics, Mood Stabilizers

← Older revision		Revision as of 18:42, 15 May 2026
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	[[Category:Mood_Stabilizers]]		[[Category:Mood_Stabilizers]]
			[[Category:Sodium channel blockers]]
			[[Category:Anticonvulsants / Antiepileptics]]
			[[Category:Mood Stabilizers]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:31:04Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:31, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:45Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =

MDElliottMD: Added empty fda_max parameter to MedTemplate call

2026-05-13T02:32:41Z

Added empty fda_max parameter to MedTemplate call

← Older revision		Revision as of 02:32, 13 May 2026
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	\| starting_dose =		\| starting_dose =
	\| preparations =		\| preparations =
			\| fda_max =
	\| routes =		\| routes =
	\| onset =		\| onset =
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	[[Category:Mood_Stabilizers]]		[[Category:Mood_Stabilizers]]

MDElliottMD: Expand stub to full MedTemplate parameter set

2026-05-13T01:00:00Z

Expand stub to full MedTemplate parameter set

@@ Line 1: / Line 1: @@
 {{MedTemplate
-| generic           = Oxcarbazepine
+| generic            = Oxcarbazepine
-| brand             = Trileptal
+| brand              = Trileptal
-| classes           = Mood Stabilizer, Anticonvulsant
+| structure          =
-| mechanism         = Sodium channel blocker
+| classes            = Mood Stabilizer, Anticonvulsant
 }}
 [[Category:Mood_Stabilizers]]