MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:44Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Penicillins]]
			[[Category:Beta-lactam antibiotics]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #287

2026-05-23T04:19:17Z

parser-claude batch MedTemplate pre-fill, Top 300 #287

New page

{{MedTemplate
| generic = Penicillin G (benzylpenicillin; potassium, sodium, benzathine, procaine salts)
| brand = Bicillin L-A (benzathine), Bicillin C-R (combination procaine + benzathine), Pfizerpen (potassium IV)
| structure =
| classes = [[:Category:Penicillins|Penicillin (natural, narrow-spectrum)]], [[:Category:Beta-lactam_antibiotics|β-lactam antibiotic]]
| uses = <vote slug="syphilis-use">Syphilis (benzathine IM, all stages)</vote>, <vote slug="streptococcal-pharyngitis-prophylaxis-use">Single-dose IM treatment of streptococcal pharyngitis (benzathine)</vote>, <vote slug="rheumatic-fever-prophylaxis-use">Rheumatic fever secondary prophylaxis (benzathine IM monthly)</vote>, <vote slug="meningitis-pneumococcal-use">Pneumococcal meningitis (high-dose IV potassium G, susceptible strains)</vote>, <vote slug="endocarditis-strep-use">Streptococcal endocarditis (IV)</vote>
| starting_dose = Syphilis (primary/secondary/early latent): benzathine 2.4 million units IM × 1; neurosyphilis: aqueous crystalline G 18-24 million units/d IV continuous infusion or divided q4h × 10-14 days; strep pharyngitis: benzathine 1.2 million units IM × 1; rheumatic fever prophylaxis: benzathine 1.2 million units IM every 3-4 weeks
| preparations = Bicillin L-A 600,000; 1.2M; 2.4M U IM; aqueous crystalline (Pfizerpen) 5M, 20M U IV; procaine 600,000 U/mL IM
| fda_max = Indication-specific
| pill_id =
| routes = IM (benzathine, procaine), IV (aqueous crystalline); '''NEVER IV for benzathine — fatal cardiopulmonary events reported'''
| onset = IV: minutes; IM benzathine: depot levels last weeks
| duration = IM benzathine: 3-4 weeks of detectable levels
| halflife = Aqueous crystalline ~30 minutes; benzathine effective ~3 weeks via depot release<ref name="bicillin-label">FDA Prescribing Information, Bicillin L-A (penicillin G benzathine), Pfizer, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050719s016lbl.pdf</ref>
| bioavailability = Acid-labile; not effective orally (oral form available outside US as penicillin G salts but penicillin V is preferred for oral use)<ref name="bicillin-label" />
| pregnancy = Penicillin G is the only fully effective syphilis treatment in pregnancy; penicillin-allergic pregnant patients require desensitization.{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = <vote slug="penicillin-g-mech-claim">Penicillin G binds penicillin-binding proteins (PBPs), inhibiting transpeptidation of peptidoglycan cross-links and producing osmotic lysis of growing organisms; it is the prototype β-lactam antibiotic.</vote> Narrow-spectrum: Group A and oral streptococci, Treponema pallidum, susceptible pneumococci, meningococci, some anaerobes. Benzathine and procaine salts produce IM depot release lasting weeks (benzathine) to days (procaine) — the basis of single-dose syphilis treatment<ref name="bicillin-label" />.
}}

== References ==
<references />

Penicillin G - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #287