MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:45Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Opioid analgesics]]
			[[Category:Non-opioid analgesics]]
			[[Category:Schedule II controlled substances]]
			[[Category:Fixed-dose combinations]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, mind-medicine combination

2026-05-23T04:44:10Z

parser-claude batch MedTemplate pre-fill, mind-medicine combination

New page

{{MedTemplate
| generic = Oxycodone / Acetaminophen
| brand = Percocet, Endocet, Roxicet, Tylox, Primlev
| structure =
| classes = [[:Category:Opioid_analgesics|Opioid analgesic]], [[:Category:Non-opioid_analgesics|Non-opioid analgesic (acetaminophen)]], [[:Category:Schedule_II_controlled_substances|Schedule II controlled substance]], [[:Category:Fixed-dose_combinations|Fixed-dose combination]]
| uses = <vote slug="moderate-severe-acute-pain-use">Moderate to moderately severe acute pain</vote>, <vote slug="post-surgical-pain-use">Postoperative pain</vote>, <vote slug="cancer-breakthrough-pain-use">Cancer-related breakthrough pain (selected)</vote>
| starting_dose = 5 mg / 325 mg PO every 4-6 hours as needed; total acetaminophen <3 g/d
| preparations = Oxycodone/acetaminophen 2.5/325, 5/325, 7.5/325, 10/325 mg tablets; 5/325 mg/5 mL solution
| fda_max = Acetaminophen 4 g/d absolute (3 g/d conservative); oxycodone titrated to effect
| pill_id =
| routes = Oral
| onset = 10-30 minutes
| duration = 4-6 hours
| halflife = Oxycodone 3-5 hours; acetaminophen 1-3 hours<ref name="percocet-label">FDA Prescribing Information, Percocet (oxycodone HCl / acetaminophen), Endo, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/040330s015,040341s013,040434s003lbl.pdf</ref>
| bioavailability = ~60-87% oxycodone (high and predictable, less CYP-genotype-dependent than codeine or hydrocodone); 85-98% acetaminophen<ref name="percocet-label" />
| pregnancy = Limited use in pregnancy; chronic third-trimester opioid exposure produces neonatal opioid withdrawal syndrome and respiratory depression at delivery.{{citation needed}}
| legal = [[USLegal:Schedule II|Schedule II controlled substance]] in US. Acetaminophen content limited to ≤325 mg per dosage unit (FDA 2014)
| mechanism = <vote slug="percocet-mech-claim">Oxycodone is a semi-synthetic μ-opioid receptor agonist with high oral bioavailability; CYP3A4 N-demethylation and CYP2D6 O-demethylation (to oxymorphone) contribute to metabolism, but oxycodone itself is largely the analgesic, making it less CYP2D6-dependent than codeine or hydrocodone for efficacy. Acetaminophen adds central non-opioid analgesia.</vote> The combination is the most-prescribed opioid analgesic in the US for moderate-to-severe acute pain. CPIC PGx guidance addresses CYP2D6-driven exposure variation<ref name="cpic-opioid-cyp2d6">CPIC Guideline for CYP2D6, OPRM1, and COMT and Opioid Use, 2021. https://cpicpgx.org/guidelines/cpic-guideline-for-codeine-and-cyp2d6/</ref>.
}}

== References ==
<references />

Percocet - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, mind-medicine combination