https://pharmacopedia.wiki/index.php?action=history&feed=atom&title=Percodan
Percodan - Revision history
2026-05-28T09:23:56Z
Revision history for this page on the wiki
MediaWiki 1.46.0-beta
https://pharmacopedia.wiki/index.php?title=Percodan&diff=6914&oldid=prev
MDElliottMD: home-claude category backfill (parser-claude gap closure)
2026-05-23T10:43:45Z
<p>home-claude category backfill (parser-claude gap closure)</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:43, 23 May 2026</td>
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MDElliottMD
https://pharmacopedia.wiki/index.php?title=Percodan&diff=6512&oldid=prev
MDElliottMD: parser-claude batch MedTemplate pre-fill, mind-medicine combination
2026-05-23T04:44:11Z
<p>parser-claude batch MedTemplate pre-fill, mind-medicine combination</p>
<p><b>New page</b></p><div>{{MedTemplate<br />
| generic = Oxycodone / Aspirin<br />
| brand = Percodan<br />
| structure =<br />
| classes = [[:Category:Opioid_analgesics|Opioid analgesic]], [[:Category:NSAIDs|NSAID (aspirin)]], [[:Category:Schedule_II_controlled_substances|Schedule II controlled substance]], [[:Category:Fixed-dose_combinations|Fixed-dose combination]]<br />
| uses = <vote slug="moderate-severe-acute-pain-use">Moderate to moderately severe acute pain (less commonly prescribed than acetaminophen-opioid combinations due to NSAID GI risk)</vote><br />
| starting_dose = 1 tablet (4.8355 mg oxycodone / 325 mg aspirin) PO every 6 hours as needed<br />
| preparations = 4.8355 mg oxycodone / 325 mg aspirin tablets<br />
| fda_max = Aspirin GI/bleeding-limited; oxycodone titrated to effect<br />
| pill_id =<br />
| routes = Oral<br />
| onset = 15-30 minutes<br />
| duration = 4-6 hours<br />
| halflife = Oxycodone 3-5 hours; aspirin (acetyl group) 15-20 minutes, salicylate 2-3 hours at therapeutic doses<ref name="percodan-label">FDA Prescribing Information, Percodan (oxycodone / aspirin), Endo, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/012490s019lbl.pdf</ref><br />
| bioavailability = Oxycodone 60-87%; aspirin 50-75%<ref name="percodan-label" /><br />
| pregnancy = Avoid; aspirin teratogenicity concerns plus opioid neonatal withdrawal.{{citation needed}}<br />
| legal = [[USLegal:Schedule II|Schedule II controlled substance]] in US<br />
| mechanism = <vote slug="percodan-mech-claim">Oxycodone provides μ-opioid receptor agonism for opioid analgesia; aspirin (acetylsalicylic acid) provides non-selective COX-1/COX-2 inhibition with anti-inflammatory and antiplatelet effects in addition to analgesic.</vote> Falling out of favor for acute pain due to aspirin's GI bleeding and antiplatelet effects compared with acetaminophen-opioid combinations; still used in selected indications<ref name="percodan-label" />.<br />
}}<br />
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== References ==<br />
<references /></div>
MDElliottMD