Pimavanserin - Revision history

MDElliottMD: Category taxonomy (#23): retag to house-compliant neuroleptic categories

2026-05-22T14:41:29Z

Category taxonomy (#23): retag to house-compliant neuroleptic categories

← Older revision		Revision as of 14:41, 22 May 2026
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	[[Category:Atypical Antipsychotics]]		[[Category:Atypical Antipsychotics]]
	[[Category:~~Antipsychotics~~]]		[[Category:Neuroleptics]]
	[[Category:Psychotic Disorders]]		[[Category:Psychotic Disorders]]

MDElliottMD: Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved.

2026-05-19T03:16:10Z

Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved.

← Older revision		Revision as of 03:16, 19 May 2026
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	\| brand = Nuplazid		\| brand = Nuplazid
	\| classes = Selective 5HT2A inverse agonist (with weaker 5HT2C inverse agonism)		\| classes = Selective 5HT2A inverse agonist (with weaker 5HT2C inverse agonism)
	\| mechanism = Selective inverse agonist at 5HT2A receptors with weaker activity at 5HT2C. Has no significant dopamine D2 affinity — unique among approved antipsychotics. Inverse agonism (rather than antagonism) reduces constitutive 5HT2A receptor activity below baseline.		\| mechanism = Selective inverse agonist at 5HT2A receptors with weaker activity at 5HT2C. Has no significant dopamine D2 affinity, unique among approved antipsychotics. Inverse agonism (rather than antagonism) reduces constitutive 5HT2A receptor activity below baseline.
	\| uses = Hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Investigational for psychosis in other dementias and as augmentation for depression.		\| uses = Hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Investigational for psychosis in other dementias and as augmentation for depression.
	\| starting_dose = 34 mg PO once daily		\| starting_dose = 34 mg PO once daily
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	\| pregnancy = Limited data; avoid		\| pregnancy = Limited data; avoid
	\| legal = Rx. FDA black-box warning for increased mortality in elderly patients with dementia-related psychosis (class warning shared with all antipsychotics)		\| legal = Rx. FDA black-box warning for increased mortality in elderly patients with dementia-related psychosis (class warning shared with all antipsychotics)
	\| intro = '''Pimavanserin''' (brand name Nuplazid) is the only FDA-approved medicine for the treatment of hallucinations and delusions in Parkinson's disease psychosis (approved April 2016). Unlike every other approved antipsychotic, it has '''no D2 dopamine receptor activity''' — a critical feature in Parkinson's, where conventional D2 antagonists worsen motor symptoms. Mechanism: selective 5HT2A inverse agonism with weaker 5HT2C inverse agonism. Carries the class black-box warning for increased mortality when used in elderly dementia-related psychosis, though it has been studied in that population and is investigational for dementia psychosis. Also studied as augmentation for major depression with positive preliminary results.		\| intro = '''Pimavanserin''' (brand name Nuplazid) is the only FDA-approved medicine for the treatment of hallucinations and delusions in Parkinson's disease psychosis (approved April 2016). Unlike every other approved antipsychotic, it has '''no D2 dopamine receptor activity''', a critical feature in Parkinson's, where conventional D2 antagonists worsen motor symptoms. Mechanism: selective 5HT2A inverse agonism with weaker 5HT2C inverse agonism. Carries the class black-box warning for increased mortality when used in elderly dementia-related psychosis, though it has been studied in that population and is investigational for dementia psychosis. Also studied as augmentation for major depression with positive preliminary results.
	\| pharmacodynamics= Selective 5HT2A inverse agonist (Ki ~0.4 nM). Weaker 5HT2C inverse agonism. No significant binding at D2, muscarinic, adrenergic, or histaminergic receptors. The lack of D2 activity preserves dopaminergic function (essential in PD) while reducing the 5HT2A-mediated psychotic symptoms.		\| pharmacodynamics= Selective 5HT2A inverse agonist (Ki ~0.4 nM). Weaker 5HT2C inverse agonism. No significant binding at D2, muscarinic, adrenergic, or histaminergic receptors. The lack of D2 activity preserves dopaminergic function (essential in PD) while reducing the 5HT2A-mediated psychotic symptoms.
	\| effects = Peripheral edema, confusion, nausea, constipation, gait disturbance, hallucinations (paradoxically reported), QT prolongation (avoid combination with other QT-prolonging medicines).		\| effects = Peripheral edema, confusion, nausea, constipation, gait disturbance, hallucinations (paradoxically reported), QT prolongation (avoid combination with other QT-prolonging medicines).

Maintenance script: Terminology sweep: drug/medication → medicine

2026-05-16T02:27:26Z

Terminology sweep: drug/medication → medicine

← Older revision		Revision as of 02:27, 16 May 2026
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	\| pregnancy = Limited data; avoid		\| pregnancy = Limited data; avoid
	\| legal = Rx. FDA black-box warning for increased mortality in elderly patients with dementia-related psychosis (class warning shared with all antipsychotics)		\| legal = Rx. FDA black-box warning for increased mortality in elderly patients with dementia-related psychosis (class warning shared with all antipsychotics)
	\| intro = '''Pimavanserin''' (brand name Nuplazid) is the only FDA-approved ~~medication~~ for the treatment of hallucinations and delusions in Parkinson's disease psychosis (approved April 2016). Unlike every other approved antipsychotic, it has '''no D2 dopamine receptor activity''' — a critical feature in Parkinson's, where conventional D2 antagonists worsen motor symptoms. Mechanism: selective 5HT2A inverse agonism with weaker 5HT2C inverse agonism. Carries the class black-box warning for increased mortality when used in elderly dementia-related psychosis, though it has been studied in that population and is investigational for dementia psychosis. Also studied as augmentation for major depression with positive preliminary results.		\| intro = '''Pimavanserin''' (brand name Nuplazid) is the only FDA-approved medicine for the treatment of hallucinations and delusions in Parkinson's disease psychosis (approved April 2016). Unlike every other approved antipsychotic, it has '''no D2 dopamine receptor activity''' — a critical feature in Parkinson's, where conventional D2 antagonists worsen motor symptoms. Mechanism: selective 5HT2A inverse agonism with weaker 5HT2C inverse agonism. Carries the class black-box warning for increased mortality when used in elderly dementia-related psychosis, though it has been studied in that population and is investigational for dementia psychosis. Also studied as augmentation for major depression with positive preliminary results.
	\| pharmacodynamics= Selective 5HT2A inverse agonist (Ki ~0.4 nM). Weaker 5HT2C inverse agonism. No significant binding at D2, muscarinic, adrenergic, or histaminergic receptors. The lack of D2 activity preserves dopaminergic function (essential in PD) while reducing the 5HT2A-mediated psychotic symptoms.		\| pharmacodynamics= Selective 5HT2A inverse agonist (Ki ~0.4 nM). Weaker 5HT2C inverse agonism. No significant binding at D2, muscarinic, adrenergic, or histaminergic receptors. The lack of D2 activity preserves dopaminergic function (essential in PD) while reducing the 5HT2A-mediated psychotic symptoms.
	\| effects = Peripheral edema, confusion, nausea, constipation, gait disturbance, hallucinations (paradoxically reported), QT prolongation (avoid combination with other QT-prolonging ~~drugs~~).		\| effects = Peripheral edema, confusion, nausea, constipation, gait disturbance, hallucinations (paradoxically reported), QT prolongation (avoid combination with other QT-prolonging medicines).
	\| interactions = <pharmaInteractions/>		\| interactions = <pharmaInteractions/>
	}}		}}

Maintenance script: Create Pimavanserin page (Stahl-sourced detail with skepticism)

2026-05-16T01:56:00Z

Create Pimavanserin page (Stahl-sourced detail with skepticism)

New page

{{MedTemplate
| brand = Nuplazid
| classes = Selective 5HT2A inverse agonist (with weaker 5HT2C inverse agonism)
| mechanism = Selective inverse agonist at 5HT2A receptors with weaker activity at 5HT2C. Has no significant dopamine D2 affinity — unique among approved antipsychotics. Inverse agonism (rather than antagonism) reduces constitutive 5HT2A receptor activity below baseline.
| uses = Hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Investigational for psychosis in other dementias and as augmentation for depression.
| starting_dose = 34 mg PO once daily
| preparations = 10 mg, 34 mg capsules/tablets
| fda_max = 34 mg/d
| routes = Oral
| onset = Benefit over weeks of dosing
| duration = Daily dosing
| halflife = ~57 hours (parent), ~200 h (active metabolite)
| bioavailability = Not characterized; oral dosing once daily
| pregnancy = Limited data; avoid
| legal = Rx. FDA black-box warning for increased mortality in elderly patients with dementia-related psychosis (class warning shared with all antipsychotics)
| intro = '''Pimavanserin''' (brand name Nuplazid) is the only FDA-approved medication for the treatment of hallucinations and delusions in Parkinson's disease psychosis (approved April 2016). Unlike every other approved antipsychotic, it has '''no D2 dopamine receptor activity''' — a critical feature in Parkinson's, where conventional D2 antagonists worsen motor symptoms. Mechanism: selective 5HT2A inverse agonism with weaker 5HT2C inverse agonism. Carries the class black-box warning for increased mortality when used in elderly dementia-related psychosis, though it has been studied in that population and is investigational for dementia psychosis. Also studied as augmentation for major depression with positive preliminary results.
| pharmacodynamics= Selective 5HT2A inverse agonist (Ki ~0.4 nM). Weaker 5HT2C inverse agonism. No significant binding at D2, muscarinic, adrenergic, or histaminergic receptors. The lack of D2 activity preserves dopaminergic function (essential in PD) while reducing the 5HT2A-mediated psychotic symptoms.
| effects = Peripheral edema, confusion, nausea, constipation, gait disturbance, hallucinations (paradoxically reported), QT prolongation (avoid combination with other QT-prolonging drugs).
| interactions = <pharmaInteractions/>
}}

[[Category:Atypical Antipsychotics]]
[[Category:Antipsychotics]]
[[Category:Psychotic Disorders]]