MDElliottMD: home-claude house-rule fix (terminology / spelling)

2026-05-23T04:44:07Z

home-claude house-rule fix (terminology / spelling)

← Older revision		Revision as of 04:44, 23 May 2026
Line 1:		Line 1:
	Polyethylene glycol 3350 with electrolytes is an iso-osmotic bowel-cleansing preparation combining PEG 3350 with sodium chloride, sodium bicarbonate, sodium sulfate, and potassium chloride, formulated to be reconstituted to a large fixed volume (commonly 2-4 L) and consumed over several hours before colonoscopy, surgery, or radiologic imaging<ref name="golytely-label">FDA Prescribing Information, GoLYTELY (PEG-3350 and electrolytes for oral solution), Braintree, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019011s029lbl.pdf</ref>. It is clinically distinct from over-the-counter [[Polyethylene Glycol 3350]] (Miralax), which is plain PEG 3350 without electrolytes, dosed in tablespoons for chronic constipation rather than ~~litres~~ for procedural prep.		Polyethylene glycol 3350 with electrolytes is an iso-osmotic bowel-cleansing preparation combining PEG 3350 with sodium chloride, sodium bicarbonate, sodium sulfate, and potassium chloride, formulated to be reconstituted to a large fixed volume (commonly 2-4 L) and consumed over several hours before colonoscopy, surgery, or radiologic imaging<ref name="golytely-label">FDA Prescribing Information, GoLYTELY (PEG-3350 and electrolytes for oral solution), Braintree, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019011s029lbl.pdf</ref>. It is clinically distinct from over-the-counter [[Polyethylene Glycol 3350]] (Miralax), which is plain PEG 3350 without electrolytes, dosed in tablespoons for chronic constipation rather than liters for procedural prep.

	{{MedTemplate		{{MedTemplate

MDElliottMD: home-claude punt-list stub, Top 300 #273

2026-05-23T04:41:14Z

home-claude punt-list stub, Top 300 #273

New page

Polyethylene glycol 3350 with electrolytes is an iso-osmotic bowel-cleansing preparation combining PEG 3350 with sodium chloride, sodium bicarbonate, sodium sulfate, and potassium chloride, formulated to be reconstituted to a large fixed volume (commonly 2-4 L) and consumed over several hours before colonoscopy, surgery, or radiologic imaging<ref name="golytely-label">FDA Prescribing Information, GoLYTELY (PEG-3350 and electrolytes for oral solution), Braintree, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019011s029lbl.pdf</ref>. It is clinically distinct from over-the-counter [[Polyethylene Glycol 3350]] (Miralax), which is plain PEG 3350 without electrolytes, dosed in tablespoons for chronic constipation rather than litres for procedural prep.

{{MedTemplate
| generic = Polyethylene glycol 3350 with electrolytes
| brand = GoLYTELY, NuLYTELY, TriLyte, MoviPrep, Plenvu, Gavilyte
| structure =
| classes = [[:Category:Bowel_preparation_agents|Bowel preparation agent]], [[:Category:Osmotic_laxatives|Osmotic laxative]]
| uses = <vote slug="colonoscopy-prep-use">Colonoscopy bowel preparation</vote>, <vote slug="preoperative-bowel-prep-use">Pre-procedural / preoperative bowel cleansing</vote>
| starting_dose = 4 L oral solution (GoLYTELY-class) split-dose: 2 L evening before, 2 L morning of procedure; low-volume products (MoviPrep, Plenvu) use 1-2 L with required clear-fluid intake
| preparations = Powder for oral solution in 4 L jugs (PEG 3350 ~236 g + NaCl, NaHCO3, KCl, Na2SO4) and low-volume packets
| fda_max = 4 L per procedure (standard-volume products)
| pill_id =
| routes = Oral
| onset = First bowel movement within 1-2 hours
| duration = 4-6 hours
| halflife = Not absorbed
| bioavailability = Negligible (not absorbed)<ref name="golytely-label" />
| pregnancy = Not absorbed; generally considered acceptable when bowel prep is required{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US (most products; some low-volume packs OTC)
| mechanism = <vote slug="peg-electrolytes-mech-claim">PEG 3350 holds water in the bowel lumen by osmosis; the added electrolytes are calibrated to match plasma to prevent net fluid or electrolyte shifts during the large-volume oral intake, distinguishing electrolyte-PEG bowel preps from electrolyte-free Miralax-type laxatives.</vote> The clinical efficacy endpoint is adequate visualization at colonoscopy, scored by the Boston Bowel Preparation Scale<ref name="golytely-label" />.
}}

== References ==
<references />

Polyethylene Glycol 3350 With Electrolytes - Revision history

MDElliottMD: home-claude house-rule fix (terminology / spelling)

MDElliottMD: home-claude punt-list stub, Top 300 #273