MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:29Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Corticosteroids]]
			[[Category:Glucocorticoids]]
			[[Category:Immunosuppressants]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #38

2026-05-23T03:34:50Z

parser-claude batch MedTemplate pre-fill, Top 300 #38

New page

{{MedTemplate
| generic = Prednisone
| brand = Deltasone, Rayos (delayed-release); mostly prescribed generically
| structure =
| classes = [[:Category:Corticosteroids|Corticosteroid]], [[:Category:Glucocorticoids|Glucocorticoid (intermediate-acting)]], [[:Category:Immunosuppressants|Immunosuppressant]]
| uses = <vote slug="autoimmune-flare-use">Autoimmune disease flare</vote>, <vote slug="asthma-exacerbation-use">Asthma exacerbation</vote>, <vote slug="copd-exacerbation-use">COPD exacerbation</vote>, <vote slug="rheumatic-disease-use">Rheumatic disease</vote>, <vote slug="dermatologic-inflammation-use">Severe dermatologic inflammation</vote>, <vote slug="transplant-rejection-use">Transplant rejection</vote>
| starting_dose = 0.5-2 mg/kg/d divided or single morning dose for acute conditions; lowest effective dose for chronic conditions, with planned taper
| preparations = 1, 2.5, 5, 10, 20, 50 mg tablets; 5 mg/5 mL syrup; 5 mg/mL concentrate
| fda_max = No fixed maximum; cumulative-dose toxicity drives all chronic decisions
| pill_id =
| routes = Oral
| onset = Hours
| duration = Biologic half-life ~12-36 hours (intermediate-acting); plasma half-life shorter
| halflife = Plasma 3-4 hours; biologic ~12-36 hours<ref name="deltasone-label">FDA Prescribing Information, prednisone, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202020s000lbl.pdf</ref>
| bioavailability = 70-80% (oral)<ref name="deltasone-label" />
| pregnancy = Used when benefits outweigh risk; oral cleft signal in first-trimester exposure is debated and small in absolute terms.{{citation needed}}
| legal = [[USLegal:Prescription only|Rx-only]] in US
| mechanism = <vote slug="prednisone-mech-claim">Prednisone is an inactive prodrug converted by hepatic 11β-hydroxysteroid dehydrogenase to prednisolone, the active glucocorticoid receptor agonist; the activated receptor translocates to the nucleus and broadly remodels transcription of inflammatory, immune, and metabolic gene programs.</vote> Effects include suppression of phospholipase A2 (via lipocortin/annexin), NF-κB inhibition, lymphocyte and eosinophil depletion, monocyte/macrophage downregulation, and shifts in carbohydrate, lipid, and protein metabolism. Hepatic insufficiency reduces conversion, an argument for using prednisolone directly in severe liver disease<ref name="deltasone-label" />.
}}

== References ==
<references />

Prednisone - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #38