Promethazine - Revision history

MDElliottMD: parser-claude: Promethazine MedTemplate refill, Top 300 stub upgrade

2026-05-23T07:26:28Z

parser-claude: Promethazine MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 07:26, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Promethazine		\| generic = Promethazine (hydrochloride)
	\| brand = Phenergan		\| brand = Phenergan, Promethegan (suppositories)
	\| structure =		\| structure =
	\| classes = ~~Antihistamine~~, Antiemetic		\| classes = [[:Category:Antihistamines\|First-generation antihistamine]], [[:Category:Phenothiazines\|Phenothiazine]], [[:Category:Antiemetics\|Antiemetic]]
	\| ~~mechanism~~ = ~~H1 antagonist~~; ~~D2 antagonist~~		\| uses = <vote slug="allergic-conditions-use">Allergic conditions (FDA)</vote>, <vote slug="motion-sickness-use">Motion sickness (FDA)</vote>, <vote slug="nausea-vomiting-broad-use">Nausea and vomiting from various causes (FDA; postoperative, chemotherapy, hyperemesis gravidarum, motion sickness)</vote>, <vote slug="preoperative-sedation-use">Preoperative sedation (FDA)</vote>, <vote slug="acute-migraine-adjunct-use">Acute migraine adjunct (off-label)</vote>
	\| ~~uses~~ =		\| starting_dose = Allergy: 25 mg PO BID-QID. Nausea/vomiting: 12.5-25 mg PO/IM/IV/PR every 4-6 hours. Motion sickness: 25 mg PO 30-60 minutes before travel. '''Pediatric <2 years: contraindicated'''
	\| ~~starting_dose~~ =		\| preparations = Tablets 12.5, 25, 50 mg; oral syrup 6.25 mg/5 mL; suppositories 12.5, 25, 50 mg; injection 25 mg/mL and 50 mg/mL
	\| ~~preparations~~ =		\| fda_max = 100 mg/day (adult)
	\| ~~fda_max~~ =		\| pill_id =
	\| routes =		\| routes = Oral, IM, IV (with caution), rectal
	\| onset =		\| onset = 20 minutes (oral); 5 minutes (IV)
	\| duration =		\| duration = 4-6 hours
	\| halflife =		\| halflife = 12-15 hours<ref name="phenergan-label">FDA Prescribing Information, Phenergan (promethazine hydrochloride), Pfizer/various, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/007935s039lbl.pdf</ref>
	~~\| bioavailability =~~		\| bioavailability = ~25% (oral, with extensive first-pass)<ref name="phenergan-label" />
	~~\| pregnancy~~ =		\| pregnancy = Older agent with substantial use experience, including in hyperemesis gravidarum; broadly reassuring observational data<ref name="phenergan-label" />
	~~\| legal~~ =		\| legal = [[USLegal:Prescription only\|Rx-only]] in US. Carries two FDA '''Boxed Warnings''': (1) severe tissue injury including gangrene with IV administration, prompting recommendation for IM over IV use; (2) respiratory depression and death in children under 2 years, contraindicating use in that age group<ref name="phenergan-label" />
	\| ~~intro~~ =		\| mechanism = <vote slug="promethazine-mech-claim">'''Phenothiazine''' chemistry, sharing the receptor profile with the typical neuroleptics but used at lower doses and primarily for antihistamine and antiemetic effect rather than neuroleptic effect. Strong H1 antihistamine activity, moderate D2 antagonism (the antiemetic mechanism via chemoreceptor trigger zone in the area postrema), moderate muscarinic antagonism, and α1-adrenergic antagonism.</vote> Extrapyramidal symptoms (acute dystonia, akathisia) can occur at high doses or with chronic use, reflecting the phenothiazine D2 activity. The contraindication in children under 2 years follows fatal respiratory depression reports; the IV caution follows reports of severe tissue necrosis from extravasation despite proper technique<ref name="phenergan-label" />.
	~~\| pharmacokinetics~~ =
	\| ~~pharmacodynamics~~ =
	~~\| indications~~ =
	\| ~~dosing~~ =
	\| ~~effects =~~
	~~\| interactions~~ = ~~<pharmaInteractions~~/>
	\| ~~pregnancy_details =~~
	~~\| monitoring~~ =
	~~\| counseling~~ =
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references~~ =
	}}		}}

			== References ==
			<references />

	[[Category:Antihistamines]]		[[Category:Antihistamines]]
			[[Category:Antiemetics]]
	[[Category:Phenothiazines]]		[[Category:Phenothiazines]]
	~~[[Category:First-generation antihistamines]]~~

MDElliottMD: Comprehensive categorization: +Phenothiazines, First-generation antihistamines

2026-05-15T18:42:08Z

Comprehensive categorization: +Phenothiazines, First-generation antihistamines

← Older revision		Revision as of 18:42, 15 May 2026
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	[[Category:Antihistamines]]		[[Category:Antihistamines]]
			[[Category:Phenothiazines]]
			[[Category:First-generation antihistamines]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:31:06Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:31, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:48Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =

MDElliottMD: Added empty fda_max parameter to MedTemplate call

2026-05-13T02:32:56Z

Added empty fda_max parameter to MedTemplate call

← Older revision		Revision as of 02:32, 13 May 2026
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	\| starting_dose =		\| starting_dose =
	\| preparations =		\| preparations =
			\| fda_max =
	\| routes =		\| routes =
	\| onset =		\| onset =
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	[[Category:Antihistamines]]		[[Category:Antihistamines]]

MDElliottMD: Expand stub to full MedTemplate parameter set

2026-05-13T01:00:00Z

Expand stub to full MedTemplate parameter set

@@ Line 1: / Line 1: @@
 {{MedTemplate
-| generic           = Promethazine
+| generic            = Promethazine
-| brand             = Phenergan
+| brand              = Phenergan
-| classes           = Antihistamine, Antiemetic
+| structure          =
-| mechanism         = H1 antagonist; D2 antagonist
+| classes            = Antihistamine, Antiemetic
 }}
 [[Category:Antihistamines]]

MDElliottMD: Auto-created stub

2026-05-13T00:00:00Z

Auto-created stub

New page

{{MedTemplate
| generic = Promethazine
| brand = Phenergan
| classes = Antihistamine, Antiemetic
| mechanism = H1 antagonist; D2 antagonist
}}
[[Category:Antihistamines]]