MDElliottMD: Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved.

2026-05-19T03:16:10Z

Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved.

← Older revision		Revision as of 03:16, 19 May 2026
Line 15:		Line 15:
	\| legal = Rx-only in US		\| legal = Rx-only in US
	\| mechanism = Non-selective competitive antagonist at β1 and β2 adrenergic receptors. Lipophilic; significant blood–brain barrier penetration, accounting for its CNS effects.		\| mechanism = Non-selective competitive antagonist at β1 and β2 adrenergic receptors. Lipophilic; significant blood–brain barrier penetration, accounting for its CNS effects.
	\| intro = Propranolol was the first clinically successful beta blocker, introduced in 1964 by James Black. It is non-selective and lipophilic — it crosses the blood–brain barrier readily, which makes it uniquely useful for conditions with a CNS component (performance anxiety, akathisia, essential tremor, migraine prophylaxis) but also accounts for CNS side effects (vivid dreams, fatigue, depression).		\| intro = Propranolol was the first clinically successful beta blocker, introduced in 1964 by James Black. It is non-selective and lipophilic, it crosses the blood–brain barrier readily, which makes it uniquely useful for conditions with a CNS component (performance anxiety, akathisia, essential tremor, migraine prophylaxis) but also accounts for CNS side effects (vivid dreams, fatigue, depression).
	\| indications =		\| indications =
	\| dosing =		\| dosing =
Line 27:		Line 27:
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring = Heart rate, blood pressure		\| monitoring = Heart rate, blood pressure
	\| counseling = Do not stop abruptly — taper to avoid rebound tachycardia, hypertension, or angina. Use with caution in asthma/COPD. May mask hypoglycemia symptoms in diabetics.		\| counseling = Do not stop abruptly, taper to avoid rebound tachycardia, hypertension, or angina. Use with caution in asthma/COPD. May mask hypoglycemia symptoms in diabetics.
	\| anecdotes =		\| anecdotes =
	\| seealso = [[Metoprolol]], [[Bisoprolol]], [[Nebivolol]]		\| seealso = [[Metoprolol]], [[Bisoprolol]], [[Nebivolol]]

MDElliottMD: Create Propranolol scaffold

2026-05-15T07:15:40Z

Create Propranolol scaffold

New page

{{MedTemplate
| generic = Propranolol
| brand = Inderal
| classes = Beta Blocker, Non-selective
| uses = <vote slug="hypertension-use">Hypertension</vote>, <vote slug="migraine-prophylaxis-use">Migraine prophylaxis</vote>, <vote slug="performance-anxiety-use">Performance anxiety</vote>, <vote slug="essential-tremor-use">Essential tremor</vote>, <vote slug="akathisia-use">Akathisia</vote>
| starting_dose = 10–40 mg (situational anxiety); 40 mg BID (HTN)
| preparations = 10, 20, 40, 60, 80 mg tabs; 60/80/120/160 mg ER caps; 1 mg/mL IV
| fda_max = 640 mg/d (HTN); 240 mg/d (migraine)
| routes = Oral, IV
| onset = 1–2 h (PO), immediate (IV)
| duration = 6–12 h (IR); 24 h (ER)
| halflife = 3–6 h
| bioavailability = ~25% (extensive hepatic first-pass)
| pregnancy = Category C
| legal = Rx-only in US
| mechanism = Non-selective competitive antagonist at β1 and β2 adrenergic receptors. Lipophilic; significant blood–brain barrier penetration, accounting for its CNS effects.
| intro = Propranolol was the first clinically successful beta blocker, introduced in 1964 by James Black. It is non-selective and lipophilic — it crosses the blood–brain barrier readily, which makes it uniquely useful for conditions with a CNS component (performance anxiety, akathisia, essential tremor, migraine prophylaxis) but also accounts for CNS side effects (vivid dreams, fatigue, depression).
| indications =
| dosing =
| effects =
| pk_absorption = ~25% oral bioavailability due to high hepatic first-pass extraction.
| pk_distribution = Highly lipophilic; ~90% plasma protein binding; readily crosses the BBB.
| pk_metabolism = Hepatic via CYP2D6, CYP1A2, CYP2C19. Active metabolite: 4-hydroxypropranolol.
| pk_elimination = Renal excretion of metabolites; <1% unchanged in urine.
| pharmacodynamics =
| interactions = <pharmaInteractions/>
| pregnancy_details =
| monitoring = Heart rate, blood pressure
| counseling = Do not stop abruptly — taper to avoid rebound tachycardia, hypertension, or angina. Use with caution in asthma/COPD. May mask hypoglycemia symptoms in diabetics.
| anecdotes =
| seealso = [[Metoprolol]], [[Bisoprolol]], [[Nebivolol]]
| references = <references/>
}}

[[Category:Beta Blockers]]
[[Category:Medicines]]

Propranolol - Revision history

MDElliottMD: Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved.

MDElliottMD: Create Propranolol scaffold