Psilocybin - Revision history

MDElliottMD: Link legal-status field to the USLegal: namespace

2026-05-22T16:47:30Z

Link legal-status field to the USLegal: namespace

← Older revision		Revision as of 16:47, 22 May 2026
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	\| bioavailability = Oral bioavailability of psilocin from administered psilocybin approximately 50%		\| bioavailability = Oral bioavailability of psilocin from administered psilocybin approximately 50%
	\| pregnancy = Not studied in human pregnancy; no approved clinical use in any population		\| pregnancy = Not studied in human pregnancy; no approved clinical use in any population
	\| legal = [[Schedule I]] ([[Controlled Substances Act\|United States Controlled Substances Act]] 1970); Schedule I ([[Convention on Psychotropic Substances\|United Nations Convention on Psychotropic Substances]] 1971); decriminalized possession or regulated-services-legal in a growing list of US jurisdictions ([[Oregon Measure 109\|Oregon]] 2020, [[Colorado Proposition 122\|Colorado]] 2022, [[Denver psilocybin decriminalization\|Denver]] May 2019, Oakland June 2019, others); legal sclerotium-product market in the Netherlands		\| legal = [[USLegal:DEA Schedule I\|Schedule I]] ([[Controlled Substances Act\|United States Controlled Substances Act]] 1970); Schedule I ([[Convention on Psychotropic Substances\|United Nations Convention on Psychotropic Substances]] 1971); decriminalized possession or regulated-services-legal in a growing list of US jurisdictions ([[Oregon Measure 109\|Oregon]] 2020, [[Colorado Proposition 122\|Colorado]] 2022, [[Denver psilocybin decriminalization\|Denver]] May 2019, Oakland June 2019, others); legal sclerotium-product market in the Netherlands
	\| mechanism = Prodrug to [[Psilocin\|psilocin]] (4-hydroxy-N,N-dimethyltryptamine), a partial agonist at the [[Receptor:5-HT2A\|5-HT2A]] serotonin receptor; the action that defines the classical-psychedelic mechanism		\| mechanism = Prodrug to [[Psilocin\|psilocin]] (4-hydroxy-N,N-dimethyltryptamine), a partial agonist at the [[Receptor:5-HT2A\|5-HT2A]] serotonin receptor; the action that defines the classical-psychedelic mechanism
	\| intro = Psilocybin, chemically 4-phosphoryloxy-N,N-dimethyltryptamine, is a tryptamine alkaloid produced by approximately two hundred species of mushrooms across several genera, of which [[Psilocybe]] is the most widely studied. Psilocybin is itself biologically inactive; gastric and intestinal [[Alkaline phosphatase\|alkaline phosphatases]] dephosphorylate it within minutes of absorption to [[Psilocin\|psilocin]], the psychoactive metabolite.<ref name="nichols2016">Nichols DE. Psychedelics. Pharmacol Rev. 2016;68(2):264-355. PMID: 26841800.</ref> The mushrooms have been used ceremonially across [[Mesoamerica\|Mesoamerica]] for at least two thousand years, and in their Mesoamerican context were known by the Mexica (Aztec) name teonanácatl, conventionally translated "flesh of the gods."[citation needed] The compound was isolated and named by [[Albert Hofmann]] at [[Sandoz Laboratories]] in Basel in 1958,<ref name="hofmann1958">Hofmann A, Heim R, Brack A, Kobel H. Psilocybin, ein psychotroper Wirkstoff aus dem mexikanischen Rauschpilz Psilocybe mexicana Heim. Experientia. 1958;14(3):107-109. PMID: 13537892.</ref> three years after [[R. Gordon Wasson]], a New York banker and amateur ethnomycologist, attended a velada with the Mazatec curandera [[María Sabina]] in [[Huautla de Jiménez]], Oaxaca, and brought back the first samples from which the chemistry could be worked out.		\| intro = Psilocybin, chemically 4-phosphoryloxy-N,N-dimethyltryptamine, is a tryptamine alkaloid produced by approximately two hundred species of mushrooms across several genera, of which [[Psilocybe]] is the most widely studied. Psilocybin is itself biologically inactive; gastric and intestinal [[Alkaline phosphatase\|alkaline phosphatases]] dephosphorylate it within minutes of absorption to [[Psilocin\|psilocin]], the psychoactive metabolite.<ref name="nichols2016">Nichols DE. Psychedelics. Pharmacol Rev. 2016;68(2):264-355. PMID: 26841800.</ref> The mushrooms have been used ceremonially across [[Mesoamerica\|Mesoamerica]] for at least two thousand years, and in their Mesoamerican context were known by the Mexica (Aztec) name teonanácatl, conventionally translated "flesh of the gods."[citation needed] The compound was isolated and named by [[Albert Hofmann]] at [[Sandoz Laboratories]] in Basel in 1958,<ref name="hofmann1958">Hofmann A, Heim R, Brack A, Kobel H. Psilocybin, ein psychotroper Wirkstoff aus dem mexikanischen Rauschpilz Psilocybe mexicana Heim. Experientia. 1958;14(3):107-109. PMID: 13537892.</ref> three years after [[R. Gordon Wasson]], a New York banker and amateur ethnomycologist, attended a velada with the Mazatec curandera [[María Sabina]] in [[Huautla de Jiménez]], Oaxaca, and brought back the first samples from which the chemistry could be worked out.

MDElliottMD: Category:Fungi rollout: add Category:Fungi

2026-05-22T07:09:41Z

Category:Fungi rollout: add Category:Fungi

← Older revision		Revision as of 07:09, 22 May 2026
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	[[Category:Tryptamines]]		[[Category:Tryptamines]]
	[[Category:Medicines]]		[[Category:Medicines]]
			[[Category:Fungi]]

MDElliottMD: Build out Psilocybin: full Plant-axis page (web-claude prose draft; history-first spine, 5 Pendell corners, 82-effect profile, verified citation spine)

2026-05-22T06:12:30Z

Build out Psilocybin: full Plant-axis page (web-claude prose draft; history-first spine, 5 Pendell corners, 82-effect profile, verified citation spine)

Show changes

MDElliottMD: Tier 2 taxonomy consolidation: merge Classic Psychedelics into Classical Psychedelics (Serotonergic)

2026-05-21T17:27:09Z

Tier 2 taxonomy consolidation: merge Classic Psychedelics into Classical Psychedelics (Serotonergic)

← Older revision		Revision as of 17:27, 21 May 2026
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	[[Category:Psychedelics]]		[[Category:Psychedelics]]
	[[Category:Classical Psychedelics (Serotonergic)]]		[[Category:Classical Psychedelics (Serotonergic)]]
	~~[[Category:Classic_Psychedelics]]~~
	[[Category:Tryptamines]]		[[Category:Tryptamines]]

Noob: Added effect: Hallucinations

2026-05-20T06:44:14Z

Added effect: Hallucinations

← Older revision		Revision as of 06:44, 20 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
			<effect ref="hallucinations" author="Noob"/>
	\| interactions = <pharmaInteractions/>		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =

Maintenance script: Pendell's corner: verbatim (Gnosis, p. 28)

2026-05-15T23:04:45Z

Pendell's corner: verbatim (Gnosis, p. 28)

← Older revision		Revision as of 23:04, 15 May 2026
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	{{PendellsCorner		{{PendellsCorner
	\| quote = ~~María Sabina sang the mushrooms in Mazatec~~. ~~Wasson published her in~~ '~~'Life'' magazine~~. ~~By the time the molecule was named~~, the ~~song had escaped the village~~. ~~Psilocybin is the most generous of the Allies — gentle in dose~~, ~~generous in vision, willing to meet the unprepared more than half-way~~. ~~She does not demand the surrender~~ that ~~her sister Salvia demands~~, ~~but she rewards it just as fully~~.		\| quote = Entheogenic, manifesting god within. And yet that doesn't say it. Psychedelic, revealing the soul. And yet that doesn't say it. Hallucinogenic, generating visions. And yet that doesn't say it, either.
	\| volume = Gnosis		\| volume = Gnosis
	\| ~~voice~~ = ~~curated paraphrase — replace with verbatim passage~~		\| page = 28
	}}		}}

Maintenance script: Add Pendell's corner (Gnosis)

2026-05-15T21:43:11Z

Add Pendell's corner (Gnosis)

← Older revision		Revision as of 21:43, 15 May 2026
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	}}		}}


			{{PendellsCorner
			\| quote = María Sabina sang the mushrooms in Mazatec. Wasson published her in ''Life'' magazine. By the time the molecule was named, the song had escaped the village. Psilocybin is the most generous of the Allies — gentle in dose, generous in vision, willing to meet the unprepared more than half-way. She does not demand the surrender that her sister Salvia demands, but she rewards it just as fully.
			\| volume = Gnosis
			\| voice = curated paraphrase — replace with verbatim passage
			}}

	[[Category:Psychedelics]]		[[Category:Psychedelics]]

MDElliottMD: Comprehensive categorization: +Tryptamines

2026-05-15T18:41:57Z

Comprehensive categorization: +Tryptamines

← Older revision		Revision as of 18:41, 15 May 2026
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	[[Category:Classical Psychedelics (Serotonergic)]]		[[Category:Classical Psychedelics (Serotonergic)]]
	[[Category:Classic_Psychedelics]]		[[Category:Classic_Psychedelics]]
			[[Category:Tryptamines]]

MediaWiki default: Assign pharmacological categories from List_of_CNS-active_medicines

2026-05-14T15:07:08Z

Assign pharmacological categories from List_of_CNS-active_medicines

← Older revision		Revision as of 15:07, 14 May 2026
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	}}		}}


			[[Category:Psychedelics]]
			[[Category:Classical Psychedelics (Serotonergic)]]
	[[Category:Classic_Psychedelics]]		[[Category:Classic_Psychedelics]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:31:07Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:31, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =